Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions DOI Creative Commons

Vilde Øverlien Dåstøl,

Kristine L. Haftorn, Hamid Khoshfekr Rudsari

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Objectives Juvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association seafood intake dietary contaminant exposure during pregnancy JIA risk, to identify sex differences gene-environment interactions. Methods used Norwegian Mother, Father, Child Cohort Study (MoBa), population-based prospective cohort (1999–2008). patients were identified through Patient Registry, with remaining mother-child pairs serving as controls. assessed maternal contaminants typically found in using food frequency questionnaire completed pregnancy, mainly comparing high (≥90 th percentile, P90) vs low (<P90) intake. Multivariable logistic regression calculated adjusted odds ratios (aOR), including sex-stratification analyses. A polygenic risk score (PRS) for was subsample assess Results 217 71,884 High of lean/semi-oily fish associated (aOR 1.51, 95% CI 1.02-2.22), especially among boys 2.13, 1.21-3.75). significant interaction observed total PRS, primarily those PRS (p<0.03). no associations other types or JIA. Conclusions modestly increased not explained by estimated contaminants. Our data suggest more pronounced children lower predisposition

Language: Английский

Maternal seafood intake, dietary contaminant exposure, and risk of juvenile idiopathic arthritis: exploring gene-environment interactions DOI Creative Commons

Vilde Øverlien Dåstøl,

Kristine L. Haftorn, Hamid Khoshfekr Rudsari

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 14, 2025

Objectives Juvenile idiopathic arthritis (JIA) originates from a complex interplay between genetic and environmental factors. We investigated the association seafood intake dietary contaminant exposure during pregnancy JIA risk, to identify sex differences gene-environment interactions. Methods used Norwegian Mother, Father, Child Cohort Study (MoBa), population-based prospective cohort (1999–2008). patients were identified through Patient Registry, with remaining mother-child pairs serving as controls. assessed maternal contaminants typically found in using food frequency questionnaire completed pregnancy, mainly comparing high (≥90 th percentile, P90) vs low (<P90) intake. Multivariable logistic regression calculated adjusted odds ratios (aOR), including sex-stratification analyses. A polygenic risk score (PRS) for was subsample assess Results 217 71,884 High of lean/semi-oily fish associated (aOR 1.51, 95% CI 1.02-2.22), especially among boys 2.13, 1.21-3.75). significant interaction observed total PRS, primarily those PRS (p<0.03). no associations other types or JIA. Conclusions modestly increased not explained by estimated contaminants. Our data suggest more pronounced children lower predisposition

Language: Английский

Citations

0