Electrophile–Arene Affinity: An Energy Scale for Evaluating the Thermodynamics of Electrophilic Dearomatization Reactions DOI
Wenwen Zhang,

Zuolijun Feng,

Shu‐Li You

et al.

The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(16), P. 11487 - 11501

Published: July 30, 2024

Rational design and development of organic reactions are lofty goals in synthetic chemistry. Quantitative description the properties molecules by physical parameters plays an important role this regard. In Article, we report energy scale, namely, electrophile-arene affinity (EAA), for evaluating thermodynamics electrophilic dearomatization reactions, a class transformations that can rapidly build up molecular complexity structural diversity converting planar aromatic compounds into three-dimensional cyclic molecules. The acquisition EAA data be readily achieved theoretically calculating enthalpy changes (Δ

Language: Английский

Therapeutic Approaches of Nutraceuticals in Neurological Disorders: A Review DOI Creative Commons

Vipul Kumar,

Harsh K. Gupta,

Anamika Anamika

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(2), P. 261 - 281

Published: May 25, 2024

A big problem in healthcare around the world is neurological illnesses. There a huge and financial burden on society worldwide due to dramatically increased risk of chronic sickness diseases linked with posed lifestyle changes. Fine treatment for sick illnesses few known adverse effects goal research. number functional food studies have been launched last decades an effort identify meals enhanced therapeutic activity reduced effects. As result, research into nutraceutical therapy illness prevention various extraction procedures disorders has underway. Progressive memory loss characterises Alzheimer's disease (AD), neurodegenerative disorder. The pharmaceutical options available today are expensive, come unwanted side effects, short supply. Scientists researchers noticed that nutraceuticals impact. anti-Alzheimer's efficacy was examined clinical preclinical investigations. study new targets, such as pathophysiological mechanisms unique cascades, resulted from growing understanding AD pathogenesis. Therefore, most effective well-known will be showcased present development, together brief involving antioxidants, autophagy control, anti-inflammatory, mitochondrial homeostasis, more. Nutraceuticals real-world impacts, getting your hands phytochemicals other vital bioactive ingredients therapeutically active foods top priority. Because this, term "functional foods" muddied replaced similar ones "pharmafoods," "medifoods," "vita foods," or "medicinal foods." high demand counteract interventions, there urgent need stick healthy options. may play preventative role therapies demonstrated correlation between dietary patterns factors neurodegeneration. Examining high-quality trials focus study, which touches several important topics. In light nutraceuticals' promise multi-targeted disease, it critical assess them promising lead molecules development drugs. Prospective should, according authors' understanding, take account blood-brain barrier permeability alteration, bioavailability, features randomised trials.

Language: Английский

Citations

7
Catalytic stereoselective synthesis involving hypervalent iodine-based chiral auxiliaries DOI

Samata E. Shetgaonkar,

Fateh V. Singh

Organic & Biomolecular Chemistry, Journal Year: 2023, Volume and Issue: 21(20), P. 4163 - 4180

Published: Jan. 1, 2023

A number of organic transformations have been achieved using hypervalent iodine reagents under mild reaction conditions. The use these as chiral organocatalyst exhibited highly selective asymmetric reactions.

Language: Английский

Citations

13
sSPhos: A General Ligand for Enantioselective Arylative Phenol Dearomatization via Electrostatically-Directed Palladium Catalysis DOI Creative Commons

Max Kadarauch,

David M. Whalley, Robert J. Phipps

et al.

Journal of the American Chemical Society, Journal Year: 2023, Volume and Issue: 145(47), P. 25553 - 25558

Published: Nov. 16, 2023

Arylative phenol dearomatization affords complex, cyclohexanone-based scaffolds from simple starting materials, and asymmetric versions allow access to valuable enantioenriched structures. However, bespoke chiral ligands must typically be identified for each new scaffold variation. We have addressed this limitation by applying the concept of electrostatically-directed palladium catalysis whereby sulfonated ligand sSPhos engages in electrostatic interactions with a phenolate substrate via its associated alkali metal cation. This approach allows highly spirocyclohexadienones, process originally reported Buchwald co-workers predominantly racemic manner. In addition, is proficient at forming two other distinct scaffolds, which had previously required fundamentally different ligands, as well novel oxygen-linked scaffold. envisage that broad generality displayed will facilitate expansion important reaction type highlight potential unusual design principle, harnesses attractive interactions.

Language: Английский

Citations

13
Biological Benefits of Diallyl Disulfide, A Garlic-Derived Natural Organic Sulfur Compound DOI Creative Commons

Amle Vandana Sonaji,

Ade Rajkumar Pradeep,

Chapke Sima Ganesh

et al.

Journal for Research in Applied Sciences and Biotechnology, Journal Year: 2024, Volume and Issue: 3(1), P. 147 - 153

Published: Feb. 29, 2024

There is a possibility that diallyl disulfide and trisulfide can alleviate neuropathic pain in rats have been subjected to CCI. The mechanisms by which these compounds entail an increase the levels of H2S, BDNF, Nrf2 sciatic nerve dorsal root ganglion (DRG). use garlic as functional food great source pharmacologically active widely recognised generally accepted. One most important bioactive components called (DADS), it possesses number beneficial biological effects. These capabilities include anti-inflammatory, antioxidant, antibacterial, cardiovascular protective, neuroprotective, anticancer actions. In this review, roles DADS were reviewed systematic manner, molecular underlie functions explored. We high hopes review will not only offer direction insight into existing body literature, but also make possible for future study development intervention treatment other disorders.

Language: Английский

Citations

4
Photodegradation of 4-hydroxy-4,9-dihydro-4H-xanthen-4-ones under UV irradiation DOI
Anastasiya E. Tarakanova, Konstantin A. Kozhanov, E.V. Baranov

et al.

Russian Chemical Bulletin, Journal Year: 2025, Volume and Issue: 74(4), P. 947 - 955

Published: April 1, 2025

Language: Английский

Citations

0
Recent advances in catalytic oxidative reactions of phenols and naphthalenols DOI
Muhammad Adnan Bashir, Jian Wei, Huifei Wang

et al.

Organic Chemistry Frontiers, Journal Year: 2022, Volume and Issue: 9(19), P. 5395 - 5413

Published: Jan. 1, 2022

This critical review aims to provide an overview of oxidative phenol and naphthalenol transformations in nature synthetic chemistry.

Language: Английский

Citations

14
Iodine(V)-Based Oxidants in Oxidation Reactions DOI Creative Commons

Samata E. Shetgaonkar,

Subhiksha Jothish,

Toshifumi Dohi

et al.

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5250 - 5250

Published: July 6, 2023

The chemistry of hypervalent iodine reagents has now become quite valuable due to the reactivity these compounds under mild reaction conditions and their resemblance in chemical properties transition metals. environmentally friendly nature makes them suitable for Green Chemistry. Reagents with a dual nature, such as iodine(III) reagents, are capable electrophiles, while iodine(V) known strong oxidant behavior. Various including IBX DMP have been used oxidants organic synthesis either stoichiometric or catalytic amounts. In this review article, we describe various oxidation reactions induced by reported past decade.

Language: Английский

Citations

7
Efficient Synthesis of Benzospirocyclohexadienones via PIFA-Promoted Intramolecular Dearomative Spiroannulation DOI
Mingan Wang, Xinkun An, Tingting Zhang

et al.

Synthesis, Journal Year: 2024, Volume and Issue: 56(23), P. 3621 - 3629

Published: Oct. 22, 2024

Abstract A rapid and convenient method for the synthesis of differently substituted spiro[cyclohexane-1,1′-isochromane]-2,5-dien-4-one derivatives via phenyliodine(III) bis(trifluoroacetate) (PIFA)-promoted intramolecular oxidative dearomatization at para position is disclosed, with aim building a library new spirocyclohexadienone scaffolds. Subsequently, this strategy modified to access novel cyclohexanedienone-containing polycyclic compounds.

Language: Английский

Citations

2
Recent advances in transition-metal-free arylation reactions involving hypervalent iodine salts DOI Creative Commons
Ritu Mamgain,

Kokila Sakthivel,

Fateh V. Singh

et al.

Beilstein Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 20, P. 2891 - 2920

Published: Nov. 13, 2024

Diaryliodonium salts have become widely recognized as arylating agents in the last two decades. Both, symmetrical and unsymmetrical forms of these serve effective electrophilic reagents various organic syntheses. The use diaryliodoniums C–C carbon–heteroatom bond formations, particularly under metal-free conditions, has further enhanced popularity reagents. In this review, we concentrate on arylation reactions involving carbon other heteroatoms, encompassing rearrangement absence any metal catalyst, summarize advancements made five years.

Language: Английский

Citations

2
Development of Transition-Metal-Catalyzed Dearomatization Reactions DOI Open Access
Tetsuhiro Nemoto

Chemical and Pharmaceutical Bulletin, Journal Year: 2023, Volume and Issue: 71(8), P. 624 - 632

Published: July 31, 2023

To develop dearomatization reactions based on a nucleophilic activation of phenols, naphthols, and indoles, ipso-Friedel-Crafts-type C-alkylation must be selectively promoted over competitive O- or N-alkylation reactions. Resolving this chemoselectivity issue is essential for developing class reaction. We found that various could developed using appropriately designed aromatic substrates with an electrophilic moiety intramolecular This review describes the transition-metal-catalyzed by our group. π-Allylpalladium species, η3-propargylpalladium alkynes activated Au(I) silver carbene species applied as electrophiles in reaction system, which provided access to wide variety dearomatized products from planar compounds highly chemoselective manner.

Language: Английский

Citations

6