Dual Functionalization of the α,β-C–H Bonds in Alanine Ester Derivatives via Enamine–Imine Tautomerism: Construction of 4-Quinolinolate Skeletons through a Fragmentation–Reassembly Pathway DOI
Jie Mao, Yue Hu, S Z He

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Using a SbCl

Language: Английский

Synthetic Methods for Azaheterocyclic Phosphonates and Their Biological Activity: An Update 2004–2024 DOI
Martha C. Mayorquín‐Torres, Andreas Simoens, Eli Bonneure

et al.

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(12), P. 7907 - 7975

Published: May 29, 2024

The increasing importance of azaheterocyclic phosphonates in the agrochemical, synthetic, and medicinal field has provoked an intense search development synthetic routes for obtaining novel members this family compounds. This updated review covers methodologies established since 2004, focusing on synthesis phosphonates, which phosphonate moiety is directly substituted onto to structure. Emphasizing recent advances, classifies newly developed approaches according ring size providing information biological activities whenever available. Furthermore, summarizes various methods formation C–P bonds, examining sustainable such as Michaelis–Arbuzov reaction, Michaelis–Becker Pudovik Hirao coupling, Kabachnik–Fields reaction. After analyzing applications investigated years, a predominant focus evaluation these compounds anticancer agents evident. emerging underline versatility potential compounds, highlighting need continued research expand interesting family.

Language: Английский

Citations

11
SbCl3-Initiated Csp3 –Csp3 Coupling between N-Aryltetrahydroisoquinolines and Nitroalkanes via the Aerobic Oxidation of sp3 C–H Bond DOI
Yu Yuan, Xiaodong Jia,

Qiyuan Ma

et al.

Synthesis, Journal Year: 2023, Volume and Issue: 55(10), P. 1593 - 1601

Published: Jan. 12, 2023

Abstract An SbCl3-initiated Csp3 –Csp3 coupling between N-aryltetrahydroisoquinolines and nitromethanes was realized through the aerobic oxidation of sp 3 C–H bond, providing a series nitromethylated tetrahydroisoquinoline derivatives in high yields. The results exhibited that SbCl3, as cheap commercially available reagent, is an efficient initiator to promote direct functionalization sp3 bond with broad functional group tolerance, which potentially applied wider range activation reactions.

Language: Английский

Citations

4
Halogen Bond (XB) Promoted α-Tribromomethylation of N-Aryltetrahydroisoquinolines and Further Cyclization to 5,6-Dihydroindolo[2,1-a]isoquinolines DOI
Yuemei Li, Shuwei Zhang, Han Ding

et al.

The Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 88(15), P. 11310 - 11321

Published: July 13, 2023

Using CBr4 as a halogen bond donor and the source of tribromomethyl group, promoted tribromomethylation N-aryltetrahydroisoquinolines was achieved. This reaction also extended to construction dibenzopyrrocoline alkaloid skeleton through one-pot process. The mechanistic study confirmed existence bond.

Language: Английский

Citations

4
CBr4 as a Mild Oxidant‐Enabled Oxidation of a sp3 C−H Bond: A Facile Synthesis of the Persistent Iminium Salts of Tetrahydroisoquinolines DOI
Yuqin Chen, Shuwei Zhang, Yuemei Li

et al.

Chemistry - A European Journal, Journal Year: 2024, Volume and Issue: 30(14)

Published: Jan. 9, 2024

Using CBr

Language: Английский

Citations

0
Dual Functionalization of the α,β-C–H Bonds in Alanine Ester Derivatives via Enamine–Imine Tautomerism: Construction of 4-Quinolinolate Skeletons through a Fragmentation–Reassembly Pathway DOI
Jie Mao, Yue Hu, S Z He

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Using a SbCl

Language: Английский

Citations

0