Transition‐metal‐free Synthesis of tetra‐substituted Vinyl Iodides by Cascade Sequential Reaction of α‐Keto Acids, 1‐Iodoalkynes, and Alkyl Halides DOI
Xiaobao Zeng,

Zhenfeng Cheng,

Yushan Xie

et al.

Chemistry - An Asian Journal, Journal Year: 2022, Volume and Issue: 18(2)

Published: Dec. 2, 2022

The cascade sequential reaction of α-keto acids, 1-iodoalkynes, and alkyl halides are reported herein to synthesize tetra-substituted vinyl iodides. It represents an efficient protocol access a diverse range iodides starting from simple materials in one-pot fashion, featuring mild conditions, ease operation, broad substrate scope.

Language: Английский

Synthesis of Ferrocene 1,3‐Derivatives by Distal C−H Activation** DOI

Princi Gupta,

Suchithra Madhavan, Manmohan Kapur

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 135(34)

Published: June 27, 2023

Abstract The third position of cyclopentadienyl ring a monosubstituted ferrocene has remained as an inaccessible chemical space for direct functionalization. Until recently, functionalizing the C(3)‐position while bypassing predominantly active C(2)‐position is most challenging task. Herein, we report distal C−H functionalization ferrocenes using easily removable directing group with precise site‐selectivity, under Pd II / mono‐ N ‐protected amino‐acid ligand catalytic system. robust synthetic protocol leads to synthesis 1,3‐derivatives broad scope in olefins ferrocenyl methylamine moderate good yields via highly strained appended 12‐membered palladacycle intermediate.

Language: Английский

Citations

1
Mechanistic insights to define the directional role of hydrogen-bonding network between aryl oximes and propargyl alcohols in Rh(III) catalysis DOI
Yi Wang, Ping Qi, Hui Gao

et al.

Molecular Catalysis, Journal Year: 2023, Volume and Issue: 550, P. 113448 - 113448

Published: Sept. 15, 2023

Language: Английский

Citations

1
Enantioselective Synthesis of Ferrocene 1,3-Derivatives via Palladium/Norbornene Cooperative Catalysis DOI

Princi Gupta,

Prakash C. Tiwari,

Suchithra Madhavan

et al.

ACS Catalysis, Journal Year: 2024, Volume and Issue: unknown, P. 17460 - 17468

Published: Nov. 12, 2024

Herein, we report a regio-and stereoselective distal C–H functionalization protocol for ferrocenes, leading to the synthesis of planar chiral ferrocene-1,3-derivatives by Catellani-type reaction. The successful Pd(II)/norbornene catalyst combination can reach inaccessible reaction site ferrocene and accomplishes selective C(3)-arylation ferrocenyl methylamine. ligand-controlled synergistic Pd/norbornene metal–organic cooperative catalysis under aerobic conditions successfully provides an array in moderate-to-good yields with good enantio- diastereoselectivities. A unique class 1,3-ligands, including PPFA-like pincer type ligands bearing central chirality, has been synthesized following this synthetic methodology.

Language: Английский

Citations

0
Transition‐metal‐free Synthesis of tetra‐substituted Vinyl Iodides by Cascade Sequential Reaction of α‐Keto Acids, 1‐Iodoalkynes, and Alkyl Halides DOI
Xiaobao Zeng,

Zhenfeng Cheng,

Yushan Xie

et al.

Chemistry - An Asian Journal, Journal Year: 2022, Volume and Issue: 18(2)

Published: Dec. 2, 2022

The cascade sequential reaction of α-keto acids, 1-iodoalkynes, and alkyl halides are reported herein to synthesize tetra-substituted vinyl iodides. It represents an efficient protocol access a diverse range iodides starting from simple materials in one-pot fashion, featuring mild conditions, ease operation, broad substrate scope.

Language: Английский

Citations

0