Tailored Fibrils Approach via Ag(I).Peptidomimetic-Based Interface Design: Efficient Encapsulation of Diverse Active Pharmaceutical Ingredients in Wastewater Remediation during Effluent Treatment Plant (ETP) Processing DOI
Arun Sharma, Navneet Kaur, Narinder Singh

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Pharmaceutical pollution in wastewater poses significant environmental and public health concerns worldwide. Chloramphenicol (CP), an antibiotic widely used medical veterinary applications, is among the active pharmaceutical ingredients (APIs) frequently detected aquatic environments. This study explored encapsulation of chloramphenicol API contaminated using rationally designed fibrations based on silver metal ion-directed self-assembly fibrillator-type self-assembling ligand (ANS-3). We further investigated removal various commonly prescribed drugs, including antibiotics such as β-lactam (amoxicillin), fluoroquinolone (ciprofloxacin), aminoglycoside (neomycin), tetracycline; antiparasitic agents with antiprotozoal properties (praziquantel metronidazole); nonsteroidal anti-inflammatory drugs (NSAIDs) phenylbutazone ketoprofen; vasodilator isoxsuprine; amphiphilic antidepressants (amitriptyline); antiviral drug amantadine. The findings validated crucial influence polar multifunctionality structural complexity enhancing interactions Ag.ANS-3 matrix, emphasizing its potential for efficient sequestration. First, picolinic acid (PA) phenylalanine (F) were evaluated their ability to form fibrillar structures, morphological characterization revealed well-defined networks varying degrees porosity interconnectivity. Then, strategic inclusion leucine synthesizing ANS-3 facilitated formation robust networks, employing hydrophobic drive process. Finally, APIs was Ag(I) ion-driven self-assembled nanofibrous material. research contributes development innovative physicochemical treatment strategies remediation validates importance rational design encapsulation-based technologies.

Language: Английский

Tailored Fibrils Approach via Ag(I).Peptidomimetic-Based Interface Design: Efficient Encapsulation of Diverse Active Pharmaceutical Ingredients in Wastewater Remediation during Effluent Treatment Plant (ETP) Processing DOI
Arun Sharma, Navneet Kaur, Narinder Singh

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Pharmaceutical pollution in wastewater poses significant environmental and public health concerns worldwide. Chloramphenicol (CP), an antibiotic widely used medical veterinary applications, is among the active pharmaceutical ingredients (APIs) frequently detected aquatic environments. This study explored encapsulation of chloramphenicol API contaminated using rationally designed fibrations based on silver metal ion-directed self-assembly fibrillator-type self-assembling ligand (ANS-3). We further investigated removal various commonly prescribed drugs, including antibiotics such as β-lactam (amoxicillin), fluoroquinolone (ciprofloxacin), aminoglycoside (neomycin), tetracycline; antiparasitic agents with antiprotozoal properties (praziquantel metronidazole); nonsteroidal anti-inflammatory drugs (NSAIDs) phenylbutazone ketoprofen; vasodilator isoxsuprine; amphiphilic antidepressants (amitriptyline); antiviral drug amantadine. The findings validated crucial influence polar multifunctionality structural complexity enhancing interactions Ag.ANS-3 matrix, emphasizing its potential for efficient sequestration. First, picolinic acid (PA) phenylalanine (F) were evaluated their ability to form fibrillar structures, morphological characterization revealed well-defined networks varying degrees porosity interconnectivity. Then, strategic inclusion leucine synthesizing ANS-3 facilitated formation robust networks, employing hydrophobic drive process. Finally, APIs was Ag(I) ion-driven self-assembled nanofibrous material. research contributes development innovative physicochemical treatment strategies remediation validates importance rational design encapsulation-based technologies.

Language: Английский

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