Predicting the evolution from first-episode psychosis to mood or psychotic disorder: A systematic review of biological markers DOI Creative Commons

Raphaël Terrisse,

Florian Stéphan,

Michel Walter

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 26 - 38

Published: Jan. 9, 2025

The development of paraclinical tools to assist clinical assessment is already widespread in nearly all other medical specialties. In psychiatry, many efforts are being made improve management strategies using these new techniques. first episode psychosis (FEP) a entity whose evolution after onset difficult predict the current state our practices. Our main objective was identify from literature most promising biological markers for early prediction thymic or psychotic trajectories following FEP. We performed systematic review on 4 databases: PubMed, Scopus, PsycINFO, and Web Science PRISMA guidelines search terms related FEP biomarkers. Eight studies were included final analysis. Several biomarkers showed discriminatory capacities predicting post-FEP evolution: interleukins IL-6, IL-12p40, IL-1β, mRNA expression levels DICER-1 AKT-1 genes. Other that opted broad-spectrum also highlighted leads discovery additional Overall, results indicate value replicating targeting analysis predictive several markers. It appears important homogenize methodologies favor construction models reinforce their statistical significance.

Language: Английский

Predicting the evolution from first-episode psychosis to mood or psychotic disorder: A systematic review of biological markers DOI Creative Commons

Raphaël Terrisse,

Florian Stéphan,

Michel Walter

et al.

Journal of Affective Disorders, Journal Year: 2025, Volume and Issue: 374, P. 26 - 38

Published: Jan. 9, 2025

The development of paraclinical tools to assist clinical assessment is already widespread in nearly all other medical specialties. In psychiatry, many efforts are being made improve management strategies using these new techniques. first episode psychosis (FEP) a entity whose evolution after onset difficult predict the current state our practices. Our main objective was identify from literature most promising biological markers for early prediction thymic or psychotic trajectories following FEP. We performed systematic review on 4 databases: PubMed, Scopus, PsycINFO, and Web Science PRISMA guidelines search terms related FEP biomarkers. Eight studies were included final analysis. Several biomarkers showed discriminatory capacities predicting post-FEP evolution: interleukins IL-6, IL-12p40, IL-1β, mRNA expression levels DICER-1 AKT-1 genes. Other that opted broad-spectrum also highlighted leads discovery additional Overall, results indicate value replicating targeting analysis predictive several markers. It appears important homogenize methodologies favor construction models reinforce their statistical significance.

Language: Английский

Citations

0