A quantitative analysis of bestrophin 1 cellular localization in mouse cerebral cortex
Acta Physiologica,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 28, 2024
Calcium-activated
ligand-gated
chloride
channels,
beyond
their
role
in
maintaining
anion
homeostasis,
modulate
neuronal
excitability
by
facilitating
nonvesicular
neurotransmitter
release.
BEST1,
a
key
member
of
this
family,
is
permeable
to
γ-aminobutyric
acid
(GABA)
and
glutamate.
While
astrocytic
BEST1
well-studied
known
regulate
levels,
its
distribution
other
brain
cell
types
remain
unclear.
This
study
aimed
reassess
the
localization
mouse
cerebral
cortex.
Language: Английский
Physiology of neuroglia of the central nervous system
Handbook of clinical neurology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 69 - 91
Published: Jan. 1, 2025
Language: Английский
Neuroglia in leukodystrophies
Elly M. Hol,
No information about this author
Werner Dykstra,
No information about this author
J. Chevalier
No information about this author
et al.
Handbook of clinical neurology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 159 - 175
Published: Jan. 1, 2025
Language: Английский
Glutathione Metabolism of the Brain—The Role of Astrocytes
Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(5)
Published: May 1, 2025
ABSTRACT
Astrocytes
have
essential
functions
in
the
brain
as
partners
of
neurons
many
metabolic
and
homeostatic
processes.
The
metabolism
tripeptide
GSH
(γ‐L‐glutamyl‐L‐cysteinyl‐glycine)
is
an
important
example
a
interaction
between
astrocytes
neurons.
present
cells
millimolar
concentrations
has
antioxidant
substrate
for
detoxification
reactions.
A
high
content
protects
against
oxidative
stress
toxins
therefore
beneficial
astrocytic
self‐defense
that
helps
to
maintain
will
enable
eliminate
potential
before
they
may
reach
other
cells.
In
addition,
provide
with
amino
acids
required
synthesis
process
involves
export
from
by
multidrug
resistance
protein
1,
extracellular
processing
via
γ‐glutamyl
transpeptidase
generate
dipeptide
cysteinyl‐glycine,
cleavage
this
neuronal
ectopeptidase
aminopeptidase
N.
As
strongly
depends
on
cytosolic
concentration,
also
facilitate
release
thereby
supply
precursors
neighboring
article,
we
give
overview
current
knowledge
astrocytes,
address
how
can
help
functions,
discuss
open
questions
future
perspectives
research
healthy
diseased
brain.
image
Language: Английский
Neuroglial Advances: New Roles for Established Players
Journal of Neurochemistry,
Journal Year:
2025,
Volume and Issue:
169(5)
Published: May 1, 2025
ABSTRACT
Neuroglial
cells
perform
numerous
physiological
functions
and
contribute
to
the
pathogenesis
of
all
diseases
nervous
system.
neuroprotection
defines
resilience
tissue
exo‐
endogenous
pathological
challenges,
while
neuroglial
defence
determines
progression
outcome
neurological
disorders.
IN
this
paper,
we
overview
previously
unknown
but
recently
discovered
roles
various
types
in
diverse
processes.
First,
describe
role
ependymal
glia
regulation
cerebrospinal
fluid
flow
from
spinal
cord
peripheral
tissues
through
nerves.
This
newly
pathway
provides
a
highway
for
CNS–body
volume
transmission.
Next,
present
mechanism
by
which
astrocytes
control
migration
differentiation
oligodendrocyte
precursor
(OPCs).
In
pre‐
early
postnatal
CNS,
OPCs
migrate
using
vasculature
(which
is
yet
free
limitans
perivascularis)
as
pathfinder.
Newly
forming
astrocytic
perivascular
endfeet
signal
(through
semaphorin‐plexin
cascade)
that
detach
vessels
start
differentiate
into
myelinating
oligodendrocytes.
We
continue
astrocyte
theme
demonstrating
neuroprotective
APOE‐laden
extracellular
vesicles
neuromyelitis
optica.
explore
link
between
morphology
stress‐induced
depression.
discuss
critical
ezrin,
cytosolic
linker
defining
terminal
arborisation
stress:
overexpression
ezrin
prefrontal
cortical
makes
mice
resistant
stress,
whereas
knockdown
increases
animals
vulnerability
stress.
Subsequently,
highlight
pathophysiological
oligodendroglial
lineage
schizophrenia
describing
novel
hypertrophied
post‐mortem
patient's
mouse
model
with
overexpressing
alternative
splice
variant
DISC1‐Δ3.
These
DISC1‐Δ3‐OPCs
demonstrated
overactivated
Wnt/β‐catenin
signalling
were
sufficient
trigger
behaviours.
Finally,
deliberate
on
microglial
connexin
43
hemichannels
Alzheimer's
disease
new
formula
Cx43
hemichannel
inhibitor
increased
blood–brain
barrier
penetration
brain
retention.
image
Language: Английский
Astrocytes and Tinnitus
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1213 - 1213
Published: Nov. 29, 2024
Tinnitus
is
correlated
with
anomalies
of
neural
plasticity
and
has
been
found
to
be
affected
by
inflammatory
status.
The
current
theories
on
tinnitus,
although
still
somewhat
incomplete,
are
based
maladaptive
mechanisms.
Astrocytes
play
a
major
role
in
both
responses
inflammation
regulation;
moreover,
they
have
recently
discovered
encode
“context”
for
neuronal
circuits,
which
similar
the
“expectation”
Bayesian
brain
models.
Therefore,
this
narrative
review
explores
possible
likely
roles
astrocytes
mechanisms
leading
acute
chronic
tinnitus.
Language: Английский