Synthesis and characterization of new highly fluorinated phosphoramidates bearing different alkylamino groups DOI

Samar Argoubi,

M.A.K. Sanhoury,

I. Zerough

et al.

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(15), P. 1273 - 1283

Published: July 23, 2024

Seventeen new highly fluorinated phosphoramidates containing alkylamino moieties of the type (RFO)2P(O)NHR (R = CH2CH2CH3, (CH2)3CH3, (CH2)4-CH3, CH(CH3)2, C6H11, CH2CH2-C6H5, CH2-C6H5 or C6H5; RF CH2CF3, CH2C2F5 CH2CH2C6F13) were synthesized. These compounds obtained through reaction primary amines with bis(polyfluoroalkyl)phosphites as phosphorylating agents, using molecular iodine a mild catalyst and in presence H2O2.This method was chosen out various literature common methods, which thoroughly investigated 31P NMR spectroscopy. In addition, variation rates among different phosphites studied compared previous research findings. The title fully characterized multinuclear (1H,13C,31P, 19F) NMR, IR, HRMS techniques.

Language: Английский

Analytical‐Quality‐by‐Design Fluoroprobes for Quantitation of Entecavir and Penciclovir in Spiked Human Plasma and Content Uniformity Testing: Insights of DNA Mismatching, Three‐Colors Assessment and Sustainability Profiling DOI Open Access
Sarah S. Saleh, Ahmed Samir,

Omnia A. El‐Naem

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 1, 2025

ABSTRACT Entecavir and penciclovir are nucleoside‐analog antiviral drugs structurally related to guanine that act by inhibiting the active viral replication process. Through this study, quantitation of both was carried out using two fluorescent probes, referred as fluoroprobes. The first type prepared addition surfactants such Tween 80 sodium dodecyl sulfate (micelle‐enhanced fluoroprobes), while second includes formation a tertiary complex drug‐terbium‐DNA (Tb‐DNA fluoroprobes). preparation fluoroprobes optimized analytical quality design (AQbD) via I‐optimal design. A positive effect selected on DNA mismatching observed. procedures were validated according ICH guidelines with linearity range 2.0–40.0 μM 25.0–300.0 nM for micelle‐enhanced Tb‐DNA fluoroprobes, respectively. evaluated in compliance three‐color (GBW) assessments: greenness (using AGREE ComplexGAPI metrics), blueness BAGI tool), whiteness RGB algorithm). sustainability profiles established efficient‐valid‐green (EVG) framework. Both types successfully applied quantify entecavir content uniformity testing spiked human plasma simpler cheaper alternative hyphenated techniques.

Language: Английский

Citations

0
Determination of baloxavir marboxil in pharmaceutical preparations and spiked human plasma using its quenching action on acetoxymercuric fluorescein reagent: Assessment of greenness and whiteness DOI Creative Commons

Mohamed S. Nasr,

Mohamed M. Y. Kaddah, Samir Morshedy

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32120 - e32120

Published: May 29, 2024

A straightforward, reliable, and cost-effective spectrofluorimetric approach has been established for the analysis of baloxavir marboxil (BXM) in raw material, tablets, as well spiked human plasma. The relies on BXM's quenching impact acetoxymercuric fluorescein (AMF) fluorescence intensity. To improve reaction, factors such AMF's concentration, solution's pH, diluting solvents, reaction time were examined optimized. Linearity, range, accuracy, precision, LOD, LOQ all verified compliance with ICH criteria. concentration range was shown to be linear between 0.2 2 μg/mL. technique effectively utilized BXM both its tablet plasma, mean % recoveries 101 ± 0.36 98.77 0.65, respectively. Two assessment models (AGREE RGB-12) used compare proposed process's greenness sustainability four previously published chromatographic techniques. Higher green qualities declared by suggested than earlier ones.

Language: Английский

Citations

1
An environmentally sustainable synchronous spectrofluorimetric method coupled with second derivative signal processing for simultaneous determination of velpatasvir and simeprevir in pharmaceutical and plasma samples DOI
Sherif Ramzy, Sameer Alshehri, Maram H. Abduljabbar

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 326, P. 125202 - 125202

Published: Sept. 23, 2024

Language: Английский

Citations

1
Synthesis and characterization of new highly fluorinated phosphoramidates bearing different alkylamino groups DOI

Samar Argoubi,

M.A.K. Sanhoury,

I. Zerough

et al.

Synthetic Communications, Journal Year: 2024, Volume and Issue: 54(15), P. 1273 - 1283

Published: July 23, 2024

Seventeen new highly fluorinated phosphoramidates containing alkylamino moieties of the type (RFO)2P(O)NHR (R = CH2CH2CH3, (CH2)3CH3, (CH2)4-CH3, CH(CH3)2, C6H11, CH2CH2-C6H5, CH2-C6H5 or C6H5; RF CH2CF3, CH2C2F5 CH2CH2C6F13) were synthesized. These compounds obtained through reaction primary amines with bis(polyfluoroalkyl)phosphites as phosphorylating agents, using molecular iodine a mild catalyst and in presence H2O2.This method was chosen out various literature common methods, which thoroughly investigated 31P NMR spectroscopy. In addition, variation rates among different phosphites studied compared previous research findings. The title fully characterized multinuclear (1H,13C,31P, 19F) NMR, IR, HRMS techniques.

Language: Английский

Citations

0