Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Several pyrazole‐thiazole hybrids featuring two potentially bioactive pharmacophores with or without linker have been synthesized using the molecular hybridization approach as target structures by medicinal chemists to modulate multiple drug targets simultaneously. The presented review aims provide an overview of diversified and wide array pharmacological activities these bestowing anticancer, antifungal, antibacterial, analgesic, anti‐inflammatory, antioxidant, antitubercular, antiviral, antiparasitic, miscellaneous activities. structure–activity relationships potential mechanism action are also reviewed shed light on development more effective biotargeted candidates. This focuses latest research advances in biological profile reported from 2015 present, providing researchers a comprehensive platform rationally design develop promising hybrids.

Language: Английский