Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic‐Induced Toxicity in the HCT‐116 Cell Model: A Luminesce‐Based Study DOI Open Access
Vinod K. Nelson, Shweta Krishnan, Ayed A. Dera

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 1, 2025

Arsenic is a highly menacing environmental pollutant that substantially affects the quality of life, even in traces. It develops various diseases through increasing intracellular ROS interacts with vital organs. Chelation therapy currently recommended for arsenic toxicity. However, these treatment options are not specific and only target symptoms. Besides, they also show toxic effects irreversibly damage crucial Hence, there an urgent need potential safer therapeutic strategy can prevent Therefore, this study, we have investigated SA EC individually combination against toxicity HCT-116 cells. The results obtained from experiments revealed both plant materials comparably inhibited arsenic-induced cellular by antioxidant function. Conversely, combining plants showed better cytoprotection FT-IR HPLC analysis active fractions presence polyphenol compounds (ferulic acid gallic acid) responsible pharmacological effect. This finding unique because no cytoprotective impact has been reported yet on combination.

Language: Английский

Investigating the Cytoprotective Effect of Syzygium aromaticum and Elettaria cardamomum in Arsenic‐Induced Toxicity in the HCT‐116 Cell Model: A Luminesce‐Based Study DOI Open Access
Vinod K. Nelson, Shweta Krishnan, Ayed A. Dera

et al.

Luminescence, Journal Year: 2025, Volume and Issue: 40(3)

Published: March 1, 2025

Arsenic is a highly menacing environmental pollutant that substantially affects the quality of life, even in traces. It develops various diseases through increasing intracellular ROS interacts with vital organs. Chelation therapy currently recommended for arsenic toxicity. However, these treatment options are not specific and only target symptoms. Besides, they also show toxic effects irreversibly damage crucial Hence, there an urgent need potential safer therapeutic strategy can prevent Therefore, this study, we have investigated SA EC individually combination against toxicity HCT-116 cells. The results obtained from experiments revealed both plant materials comparably inhibited arsenic-induced cellular by antioxidant function. Conversely, combining plants showed better cytoprotection FT-IR HPLC analysis active fractions presence polyphenol compounds (ferulic acid gallic acid) responsible pharmacological effect. This finding unique because no cytoprotective impact has been reported yet on combination.

Language: Английский

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