Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling DOI Creative Commons

Ling Wu,

Yingda Lin,

Songyu Gao

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 6, 2023

Background: Triple-negative breast cancer (TNBC) is one of the most prominent neoplasm disorders and lacks efficacious treatments yet. Luteolin (3',4',5,7-tetrahydroxyflavone), a natural flavonoid commonly presented in plants, has been reported to delay progression TNBC. However, precise mechanism still elusive. We aimed elucidate inhibition molecular regulation luteolin on Methods: The effects biological functions TNBC cells were first evaluated using corresponding assays for cell counting kit-8 assay, flow cytometry, wound-healing transwell migration respectively. was then analyzed by RNA sequencing verified RT-qPCR, Western blot, transmission electron microscopy, etc. Finally, vivo mouse tumor models constructed further confirm TNBC.Results: dramatically suppressed proliferation, invasion, while favoring apoptosis dose- time-dependent manner. In treated with luteolin, SGK1 AKT3 significantly downregulated their downstream gene BNIP3 upregulated. According results 3D modeling, direct binding superior that AKT3. promoted FOXO3a translocation into nucleus led transcription both vitro vivo, eventually facilitating interaction between autophagy protein. Furthermore, upregulation SGK1, induced attenuated Conclusion: inhibits inducing through SGK1-FOXO3a-BNIP3 signaling.

Language: Английский

Luteolin for neurodegenerative diseases: a review DOI Creative Commons

Dunuvilla Kavindi Jayawickreme,

Cletus Ekwosi,

Apurva Anand

et al.

Pharmacological Reports, Journal Year: 2024, Volume and Issue: 76(4), P. 644 - 664

Published: June 21, 2024

Neurodegenerative diseases such as Parkinson's disease, Alzheimer's Huntington's and multiple sclerosis affect millions of people around the world. In addition to age, which is a key factor contributing development all neurodegenerative diseases, genetic environmental components are also important risk factors. Current methods treating mostly symptomatic do not eliminate cause disease. Many studies focus on searching for natural substances with neuroprotective properties that could be used an adjuvant therapy in inhibition neurodegeneration process. These compounds include flavonoids, luteolin, showing significant anti-inflammatory, antioxidant, activity. Increasing evidence suggests luteolin may confer protection against neurodegeneration. this review, we summarize scientific reports from preclinical vitro vivo regarding beneficial effects diseases. Luteolin was studied most extensively various models disease but there several its Though very limited, possible protective discussed here. Overall, although show potential benefits disorders, clinical therapeutic efficacy still deficient.

Language: Английский

Citations

17
Flavonoids in Skin Senescence Prevention and Treatment DOI Open Access
Anna Domaszewska-Szostek, Monika Puzianowska‐Kuźnicka, Alina Kuryłowicz

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(13), P. 6814 - 6814

Published: June 25, 2021

Skin aging is associated with the accumulation of senescent cells and related to many pathological changes, including decreased protection against pathogens, increased susceptibility irritation, delayed wound healing, cancer susceptibility. Senescent secrete a specific set pro-inflammatory mediators, referred as senescence-associated secretory phenotype (SASP), which can cause profound changes in tissue structure function. Thus, drugs that selectively eliminate (senolytics) or neutralize SASP (senostatics) represent an attractive therapeutic strategy for age-associated skin deterioration. There growing evidence plant-derived compounds (flavonoids) slow down even prevent aging-associated deterioration appearance function by targeting cellular pathways crucial regulating senescence SASP. This review summarizes senostatic senolytic potential flavonoids context preventing aging.

Language: Английский

Citations

93
Targeting Nrf2-Mediated Oxidative Stress Response in Traumatic Brain Injury: Therapeutic Perspectives of Phytochemicals DOI Creative Commons
Anguo Wu,

Yuan-Yuan Yong,

Yi-Ru Pan

et al.

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 24

Published: April 4, 2022

Traumatic brain injury (TBI), known as mechanical damage to the brain, impairs normal function of seriously. Its clinical symptoms manifest behavioral impairment, cognitive decline, communication difficulties, etc. The pathophysiological mechanisms TBI are complex and involve inflammatory response, oxidative stress, mitochondrial dysfunction, blood-brain barrier (BBB) disruption, so on. Among them, one important mechanisms, occurs at beginning accompanies whole process TBI. Most importantly, excessive stress causes BBB disruption brings lipids, proteins, DNA, leading generation lipid peroxidation, nuclear neuronal apoptosis, neuroinflammatory response. Transcription factor NF-E2 related 2 (Nrf2), a basic leucine zipper protein, plays an role in regulation antioxidant such oxygenase-1(HO-1), NAD(P)H Quinone Dehydrogenase 1 (NQO1), glutathione peroxidase (GPx), protect against neuroinflammation, apoptosis. Recently, emerging evidence indicated knockout (KO) Nrf2 aggravates pathology TBI, while treatment activators inhibits apoptosis responses via reducing damage. Phytochemicals from fruits, vegetables, grains, other medical herbs have been demonstrated activate signaling pathway exert neuroprotective effects In this review, we emphasized contributive protective mechanism Nrf2-mediated response for addition, summarized research advances phytochemicals, including polyphenols, terpenoids, natural pigments, otherwise, activation their potential therapies Although there is still limited application these activators, believe that combinational use phytochemicals with gene stem cell therapy will be promising therapeutic strategy future.

Language: Английский

Citations

60
Luteolin Prevents UVB-Induced Skin Photoaging Damage by Modulating SIRT3/ROS/MAPK Signaling: An in vitro and in vivo Studies DOI Creative Commons
Jing Mu, Huisheng Ma, Hong Chen

et al.

Frontiers in Pharmacology, Journal Year: 2021, Volume and Issue: 12

Published: Aug. 30, 2021

The aim of this study was to investigate the role luteolin in mechanism ultraviolet radiation B (UVB)-induced photoaging. An vivo photoaging model established using UVB irradiation bare skin on back rats, and an vitro human dermal fibroblasts (HDF). Skin damage observed hematoxylin-eosin (HE) Masson staining, cellular reactive oxygen species (ROS) levels were detected by DHE DCF fluorescent probes, mitochondrial membrane potential JC-1 protein expressions immunofluorescence Western Blot. Results from animal experiments showed that reduced UVB-induced erythema wrinkle formation. assays inhibited decrease cell viability. In addition, oxidative stress levels, decreased activation matrix metalloproteinases (MMPs) increased collagen expression. Continued 3-TYP, inhibitor Sirtuin 3 (SIRT3), revealed a loss protection collagen, suggesting acts targeting promoting SIRT3. is involved cells against radiation-induced ageing via SIRT3/ROS/mitogen-activated kinases (MAPK) axis it may be promising therapeutic agent for prevention

Language: Английский

Citations

58
The Molecular Mechanism of Polyphenols with Anti-Aging Activity in Aged Human Dermal Fibroblasts DOI Creative Commons

Joo Hwa Lee,

Jooho Park, Dong Wook Shin

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(14), P. 4351 - 4351

Published: July 7, 2022

Skin is the largest organ in body comprised of three different layers including epidermis, dermis, and hypodermis. The dermis mainly composed dermal fibroblasts extracellular matrix (ECM), such as collagen elastin, which are strongly related to skin elasticity firmness. continuously exposed kinds environmental stimuli. For example, ultraviolet (UV) radiation, air pollutants, or smoking aggravates aging. These external stimuli accelerate aging process by reactive oxygen species (ROS)-mediated signaling pathways even cause aging-related diseases. characterized loss, wrinkle formation, a reduced dermal-epidermal junction, delayed wound healing. Thus, many studies have shown that natural polyphenol compounds can delay regulating age-related aged fibroblasts. This review first highlights relationship between its molecular mechanisms. Then, we discuss function underlying mechanism various polyphenols for improving study may provide essential insights developing functional cosmetics future clinical applications.

Language: Английский

Citations

55
Elucidation of the Metabolite Profile of Yucca gigantea and Assessment of Its Cytotoxic, Antimicrobial, and Anti-Inflammatory Activities DOI Creative Commons

Nashwah G. M. Attallah,

Suzy A. El-Sherbeni, Aya H. El-Kadem

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(4), P. 1329 - 1329

Published: Feb. 16, 2022

The acute inflammation process is explained by numerous hypotheses, including oxidative stress, enzyme stimulation, and the generation of pro-inflammatory cytokines. anti-inflammatory activity Yucca gigantea methanol extract (YGME) against carrageenan-induced possible underlying mechanisms was investigated. phytochemical profile, cytotoxic, antimicrobial activities were also explored. LC-MS/MS utilized to investigate chemical composition YGME, 29 compounds tentatively identified. In addition, isolation luteolin-7-O-β-d-glucoside, apigenin-7-O-β-d-glucoside, kaempferol-3-O-α-l-rhamnoside performed for first time from studied plant. Inflammation induced subcutaneous injection 100 μL 1% carrageenan sodium. Rats treated orally with YGME 100, 200 mg/kg, celecoxib (50 mg/kg), saline, respectively, one hour before injection. average volume paws edema weight measured at several intervals. Levels NO, GSH, TNF-α, PGE-2, serum IL-1β, IL-6 measured. additionally, COX-2 immunostaining histopathological examination paw tissue performed. displayed a potent influence reducing edema, NO production, IL-6, immunostaining. Furthermore, it replenished diminished GSH contents improved findings. best cytotoxic effect human melanoma cell line (A365) osteosarcoma (MG-63). Moreover, potential evaluated bacterial fungal isolates. It showed Gram-negative, Gram-positive, Candida albicans promoting multiple effects could be beneficial in treatment different ailments based on its anti-inflammatory, antimicrobial, effects.

Language: Английский

Citations

47
Plants as a Source of Anticancer Agents: From Bench to Bedside DOI Creative Commons
Wamidh H. Talib, Safa Daoud, Asma Ismail Mahmod

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4818 - 4818

Published: July 27, 2022

Cancer is the second leading cause of death after cardiovascular diseases. Conventional anticancer therapies are associated with lack selectivity and serious side effects. hallmarks biological capabilities acquired by cancer cells during neoplastic transformation. Targeting multiple a promising strategy to treat cancer. The diversity in chemical structure relatively low toxicity make plant-derived natural products source for development new more effective that have capacity target In this review, we discussed activities ten extracted from plants. majority these inhibit targeting hallmarks, many chemicals reached clinical applications. Studies review provide solid ground researchers physicians design combination using products.

Language: Английский

Citations

46
Interaction between soybean oleosome-associated proteins and phospholipid bilayer and its influence on environmental stability of luteolin-loaded liposomes DOI
Risheng Li,

Chuanfen Pu,

Yue Sun

et al.

Food Hydrocolloids, Journal Year: 2022, Volume and Issue: 130, P. 107721 - 107721

Published: April 8, 2022

Language: Английский

Citations

45
Mechanisms of ferroptosis regulating oxidative stress and energy metabolism in myocardial ischemia-reperfusion injury and a novel perspective of natural plant active ingredients for its treatment DOI Open Access
Tianqing Zhang,

Wenxu Deng,

Ying Deng

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 165, P. 114706 - 114706

Published: July 1, 2023

Acute myocardial infarction remains the leading cause of death in humans. Timely restoration blood perfusion to ischemic myocardium most effective strategy treatment acute infarction, which can significantly reduce morbidity and mortality. However, after flow reperfusion, injury will aggravate induce apoptosis cardiomyocytes, a process called ischemia-reperfusion injury. Studies have shown that loss cardiomyocytes caused by oxidative stress, iron load, increased lipid peroxidation, inflammation mitochondrial dysfunction, etc., are involved In recent years, with in-depth research on pathology injury, people gradually realized there is new form cell pathological namely ferroptosis. A number studies found tissue patients changes closely related ferroptosis, such as metabolism disorder, reactive oxygen species free radicals. Natural plant products resveratrol, baicalin, cyanidin-3-O-glucoside, naringenin, astragaloside IV also exert therapeutic effects correcting imbalance these ferroptosis-related factors expression levels. Combining our previous studies, this review summarizes regulatory mechanism natural intervening ferroptosis order provide reference information for development targeted inhibitor drugs cardiovascular diseases.

Language: Английский

Citations

36
The macrophage polarization in inflammatory dermatosis and its potential drug candidates DOI Creative Commons
Qingru Sun, Shiyu Hu, Zhaohuan Lou

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114469 - 114469

Published: March 2, 2023

Inflammatory dermatosis is characterized by persistent inflammatory infiltration and hard repair of diseased skin. As a member the human innate immune cells, macrophages usually show different phenotypes in diseases. The macrophage phenotype (M1/M2) imbalance caused increase M1 or decrease M2 common dermatosis. In recent years, with deepening research on skin diseases, more natural medicines/traditional Chinese medicines (TCMs), represented Shikonin Angelica Dahurica, have shown their therapeutic effects affecting polarization macrophages. This review introduced dermatosis, such as psoriasis. Then summarized medicines/TCMs that potential so far mechanisms action proteins/signal pathways involved. We found TCMs listed this are closely related to theory five flavors four properties medicinal, most them bitter, acrid sweet. Bitter antipyretic, anti-inflammatory antibacterial effects, which may improve inflammation infiltration. Acrid effect promoting blood circulation, while sweet nourishing. These 2 accelerate lesions conclusion, we hope provide sufficient knowledge for medicine development imbalance.

Language: Английский

Citations

34