Nutritional Status Reshapes Gut Microbiota Composition in Adolescent Afghan Refugees in Peshawar, Pakistan

Nutrition Research, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Although the human gut microbiome, and its role in health disease, have been extensively studied different populations, a comprehensive assessment of microbiome composition has not performed vulnerable refugee populations. In this study, we hypothesized that overall nutritional status, as indicated by serum micronutrients concentrations, is an important driver variations composition. Therefore, gut-microbiome diversity associated demographic, factors were assessed adolescent Afghan refugees (n=206). Blood faecal samples collected analysed for nutrition status markers 16S rRNA gene amplicon-based community profiling, respectively. Bioinformatics statistical analysis using SPSS, QIIME R. Overall, 56 distinct phyla, 117 families 252 genera identified samples. Bacterial (alpha beta diversity) Firmicutes:Bacteroidetes (F/B) ratio significantly higher 15 to 19 year old age group (cf. 10-14 group) but lower underweight vitamin D deficient groups. Furthermore, LEfSe significant differences relative abundance bacterial based on age, BMI micronutrient (vitamins minerals) status. These results further scrutinised correlation which confirmed show correlations with F/B specific taxa. Collectively, our study provides first indication how gut-microbiota profile range nutrition-status factors. findings can thus provide basis translational microbiota research aimed at improving such understudied

Language: Английский

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Microencapsulation of Lactobacillus plantarum using cellulose-based polymers by spray-drying: A probiotic-delivery system for enhanced acid-resistance and storage stability

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143634 - 143634

Published: April 1, 2025

Language: Английский

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Gut–brain communication mediates the impact of dietary lipids on cognitive capacity

Food & Function, Journal Year: 2024, Volume and Issue: 15(4), P. 1803 - 1824

Published: Jan. 1, 2024

The effects of dietary lipids on cognition, both positive and negative, are mediated through the gut–brain axis by modulating metabolic, immune, neural, endocrine pathways.

Language: Английский

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Microbiome and micronutrient in ALS: From novel mechanisms to new treatments

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00441 - e00441

Published: Aug. 31, 2024

Amyotrophic lateral sclerosis is a neurodegenerative disorder. Despite extensive studies, it remains challenging to treat ALS. Recent ALS studies have shown dysbiosis (e.g., loss of microbial diversity and beneficial function in the gut microbiota) correlated with intestinal inflammation change integrity The novel concepts roles microbiome metabolites through gut-microbiome-neuron axis pathogenesis been slowly recognized by neurology research field. Here, we will discuss recent progress microbiome, including bacteria, fungi, viruses, research. We our understanding Micronutrition refers intake essential vitamins, minerals, other micronutrients. summarize literation related micronutrition Furthermore, consider mutual interactions progression treatment. further propose that mechanistic translational shift from suspension disbelief cogent ingenuity, bench study bed-side application, should allow new strategies diagnosis treatment for

Language: Английский

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Examining the impact of crops and foods biofortified with micronutrients on the gut microbiome: A review

Food Research International, Journal Year: 2025, Volume and Issue: 209, P. 116189 - 116189

Published: March 14, 2025

Language: Английский

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