Plant Antimicrobial Compounds and Their Mechanisms of Action on Spoilage and Pathogenic Bacteria: A Bibliometric Study and Literature Review
Applied Sciences,
Journal Year:
2025,
Volume and Issue:
15(7), P. 3516 - 3516
Published: March 23, 2025
This
research
explored
the
potential
of
plant
antimicrobial
compounds
as
natural
alternatives
to
synthetic
antimicrobials
in
food
and
pharmaceutical
industries,
emphasizing
urgent
need
combat
resistance.
It
detailed
various
mechanisms
by
which
these
plant-derived
inhibit
microbial
growth,
including
disrupting
cell
membrane
integrity,
impeding
wall
protein
synthesis,
preventing
biofilm
formation,
ultimately
leading
bacterial
death.
study
highlighted
specific
effects
on
cells,
such
inhibiting
cellular
respiration,
motility,
while
also
modulating
oxygen
consumption
reactive
species
generation,
are
vital
addressing
biofilm-mediated
infections.
Additionally,
can
regulate
expression
virulence
factors
efflux
pumps,
enhancing
antibiotic
efficacy.
A
bibliometric
analysis
revealed
a
growing
trend
output
international
collaboration,
particularly
from
China
United
States,
with
key
journals
“Frontiers
Microbiology”
“Antimicrobial
Agents
Chemotherapy.”
The
identified
six
clusters
related
research,
underscoring
for
further
investigation
into
applications
bioactive
compounds.
In
conclusion,
understanding
action
is
important
their
effective
application
combating
Language: Английский
An Updated Review on the Nanocarriers Based Co‐Delivery System of Chemo Drug Doxorubicin and Phytocompounds
Polymers for Advanced Technologies,
Journal Year:
2024,
Volume and Issue:
36(1)
Published: Dec. 26, 2024
ABSTRACT
Numerous
issues
and
concerns
are
associated
with
current
cancer
therapeutics,
such
as
multidrug
resistance
tumors,
drug
toxicity,
severe
side
effects,
financial
burden.
Phytocompounds
from
plants
have
garnered
significant
interest
alternatives
adjunct
therapies
to
mitigate
these
effects
owing
their
safety,
efficacy,
cost‐effectiveness.
As
demonstrated
by
a
number
of
preclinical
clinical
investigations,
phytocompounds
combinations
doxorubicin
mediate
anticancer
modulating
multiple
signaling
pathways
linked
immune
system
mobilization,
apoptosis
promotion,
inhibition
excessive
cellular
proliferation.
However,
continue
encounter
challenges
related
inadequate
bioavailability,
pharmacokinetics,
metabolism.
To
address
challenges,
the
utilization
different
types
nanoparticles
has
become
in
nanomedicine
for
targeted
delivery,
enhancing
retention
time,
reducing
toxicity.
This
field
study
showcases
remarkable
amalgamation
nanotechnology
chemo‐drugs
(doxorubicin).
Thus,
this
review
focuses
on
recent
developments
nanocarriers
based
delivery
systems,
particularly
those
intended
simultaneous
chemotherapy
medicines,
synthesizing
existing
knowledge
filling
research
gaps.
also
discussed
combined
therapy
chemotherapeutic
drugs
other
nanotechnology‐based
carriers
treatment.
Language: Английский