Self-Exfoliated Guanidinium Covalent Organic Nanosheets as High-Capacity Curcumin Carrier DOI Creative Commons
Archita Sharma, Dhavan Sharma, Hengyu Lin

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(11), P. 709 - 709

Published: Nov. 19, 2024

Drug administration is commonly used to treat chronic wounds but faces challenges such as poor bioavailability, instability, and uncontrollable release. Existing drug delivery platforms are limited by chemical functionality, complex synthesis, toxic by-products. Presently, research efforts focused on developing novel carriers enhance efficacy. Guanidinium Covalent Organic Nanosheets (gCONs) offer promising alternatives due their high porosity, surface area, loading capacity, ability provide controlled, sustained, target-specific delivery. Herein, we successfully synthesized self-exfoliated gCONs using a Schiff base condensation reaction embedded curcumin (CUR), polyphenolic pleiotropic with antioxidant anti-inflammatory properties, via the wet impregnation method. The BET porosimeter exhibited filling of gCON pores CUR. Morphological investigations revealed formation sheet-like structures in gCON. Culturing human dermal fibroblasts (hDFs) demonstrated cytocompatibility even at concentration 1000 µg/mL. release studies controlled sustained CUR over an extended period 5 days, facilitated capacity Furthermore, inherent properties were preserved after into gCON, underscoring potential CUR-loaded formulation for effective therapeutic applications. Conclusively, this study provides fundamental information relevant performance system synergistic effect CONs addressing issues like bioavailability instability.

Language: Английский

Metal organic and covalent organic framework-based QCM sensors for environmental pollutant detection and beyond DOI

Zaynab Golshadi,

Mohammad Dinari, Alexander Knebel

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 521, P. 216163 - 216163

Published: Aug. 27, 2024

Language: Английский

Citations

13
Hybrid Nanoplatforms Based on Photosensitizers and Metal/Covalent Organic Frameworks for Improved Cancer Synergistic Treatment Nano-Delivery Systems DOI Creative Commons

Aviwe Magadla

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 884 - 884

Published: Feb. 14, 2025

Researchers have extensively investigated photosensitizer (PS) derivatives for various applications due to their superior photophysical and electrochemical properties. However, inherent problems, such as instability self-quenching under physiological conditions, limit biological applications. Metal-organic frameworks (MOFs) covalent organic (COFs) represent two relatively new material types. These materials high surface areas permanent porosity, they show a tremendous deal of potential like these. This review summarizes key synthesis processes highlights recent advancements in integrating PS-based COF MOF nanocarriers biomedical while addressing obstacles prospects.

Language: Английский

Citations

1
Silver-loaded porous crystalline frameworks materials: A synergistic strategy for advanced antibacterial applications DOI
Hui Li, Luyang Zhao, Hengyi Xu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162049 - 162049

Published: April 1, 2025

Language: Английский

Citations

0
A natural pigment-based nanosized colorimetric sensor for freshness evaluation of aquatic products DOI
Qingmin Chen,

Yuying Han,

Yilin Wang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 465, P. 141945 - 141945

Published: Nov. 6, 2024

Language: Английский

Citations

0
Self-Exfoliated Guanidinium Covalent Organic Nanosheets as High-Capacity Curcumin Carrier DOI Creative Commons
Archita Sharma, Dhavan Sharma, Hengyu Lin

et al.

Biomimetics, Journal Year: 2024, Volume and Issue: 9(11), P. 709 - 709

Published: Nov. 19, 2024

Drug administration is commonly used to treat chronic wounds but faces challenges such as poor bioavailability, instability, and uncontrollable release. Existing drug delivery platforms are limited by chemical functionality, complex synthesis, toxic by-products. Presently, research efforts focused on developing novel carriers enhance efficacy. Guanidinium Covalent Organic Nanosheets (gCONs) offer promising alternatives due their high porosity, surface area, loading capacity, ability provide controlled, sustained, target-specific delivery. Herein, we successfully synthesized self-exfoliated gCONs using a Schiff base condensation reaction embedded curcumin (CUR), polyphenolic pleiotropic with antioxidant anti-inflammatory properties, via the wet impregnation method. The BET porosimeter exhibited filling of gCON pores CUR. Morphological investigations revealed formation sheet-like structures in gCON. Culturing human dermal fibroblasts (hDFs) demonstrated cytocompatibility even at concentration 1000 µg/mL. release studies controlled sustained CUR over an extended period 5 days, facilitated capacity Furthermore, inherent properties were preserved after into gCON, underscoring potential CUR-loaded formulation for effective therapeutic applications. Conclusively, this study provides fundamental information relevant performance system synergistic effect CONs addressing issues like bioavailability instability.

Language: Английский

Citations

0