Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities DOI Creative Commons

Yun Liao,

Stacia Octaviani,

Zhen Tian

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 15, 2025

Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, long-term stability of hematopoietic stem cells (HSCs). Recent research highlights central importance MQC HSC biology, particularly roles mitophagy, biogenesis, fission, fusion transfer regulating function. Mitophagy ensures removal damaged mitochondria, low levels reactive oxygen species (ROS) HSCs, thereby preventing premature aging functional decline. Concurrently, biogenesis adjusts key regulators such as transcription factor A (TFAM) peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) to meet environmental demands, ensuring needs HSCs are met. Additionally, transfer, form intercellular material exchange, facilitates mitochondria from bone marrow stromal contributing damage repair support. Although existing studies have revealed significance function, precise molecular mechanisms interactions among different regulatory pathways remain be fully elucidated. Furthermore, potential dysfunction disorders, including its involvement disease progression therapeutic resistance, not yet understood. This review discusses functions under physiological pathological conditions, applications. By summarizing current progress this field, we aim provide insights further development innovative treatment strategies.

Language: Английский

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities DOI Creative Commons

Yun Liao,

Stacia Octaviani,

Zhen Tian

et al.

Stem Cell Research & Therapy, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 15, 2025

Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, long-term stability of hematopoietic stem cells (HSCs). Recent research highlights central importance MQC HSC biology, particularly roles mitophagy, biogenesis, fission, fusion transfer regulating function. Mitophagy ensures removal damaged mitochondria, low levels reactive oxygen species (ROS) HSCs, thereby preventing premature aging functional decline. Concurrently, biogenesis adjusts key regulators such as transcription factor A (TFAM) peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) to meet environmental demands, ensuring needs HSCs are met. Additionally, transfer, form intercellular material exchange, facilitates mitochondria from bone marrow stromal contributing damage repair support. Although existing studies have revealed significance function, precise molecular mechanisms interactions among different regulatory pathways remain be fully elucidated. Furthermore, potential dysfunction disorders, including its involvement disease progression therapeutic resistance, not yet understood. This review discusses functions under physiological pathological conditions, applications. By summarizing current progress this field, we aim provide insights further development innovative treatment strategies.

Language: Английский

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