Advances and prospects of precision nanomedicine in personalized tumor theranostics DOI Creative Commons
Yuhang Mao,

Juanping Xie,

Fang Yang

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 5, 2024

Tumor, as the second leading cause of death globally, following closely behind cardiovascular diseases, remains a significant health challenge worldwide. Despite existence various cancer treatment methods, their efficacy is still suboptimal, necessitating development safer and more efficient strategies. Additionally, advancement personalized therapy offers further possibilities in treatment. Nanomedicine, promising interdisciplinary field, has shown tremendous potential prospects diagnosis cancer. As an emerging approach oncology, application nanomedicine primarily focuses on targeted drug delivery systems such passive targeting delivery, active environmentally responsive well imaging diagnostics tumor biomarker detection, cell vivo imaging. However, it faces challenges regarding safety, biocompatibility, other issues. This review aims to explore advances use nanomaterials field investigate developing therapies care, providing direction for clinical translation application.

Language: Английский

Apoptosis‐Sensitizing Tumor Nanomedicine by Regulating Pyroptosis‐Associated Inflammatory Cell Death DOI

Fangxue Du,

Hongxin Zhao,

Yangmeihui Song

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: May 25, 2024

Abstract The vigorous development of cancer nanomedicine has revolutionized traditional oncology medicine, but it is also limited by the continuous mutation cunning cells, leading to apoptosis insensitivity and therapeutic disappointment. Inflammatory‐regulated cell death (RCD), especially pyroptosis‐related death, demonstrates huge potential for sensitization due its unique biochemical characteristics. aim this research present a thorough synopsis current knowledge on pyroptosis‐associated inflammatory including pyroptosis, cuproptosis, PANoptosis, synergistic function in nano therapy. Paradigm studies death‐mediated apoptosis‐sensitizing tumor nanotherapeutics are introduced detail, coordination mechanisms based nanomaterials discussed. In addition, multi‐angle analysis future prospects pyroptosis‐sensitized various emphasized further expand application scope RCD. It believed that emerging auxiliary treatments RCD will greatly promote progress nanomedicine.

Language: Английский

Citations

7
A mitochondria-interfering nanocomplex cooperates with photodynamic therapy to boost antitumor immunity DOI
Zhijie Zhang,

Qingfu Zhao,

Qingqing Xu

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 317, P. 123094 - 123094

Published: Jan. 7, 2025

Language: Английский

Citations

0
Oxygen/sulfate radicals-generating CaS2O8 nanosonosensitizers induce PANoptosis and calcium overload for enhanced peritoneal metastasis immunotherapy DOI
Qiang Wang,

Yingfei Wen,

Bo Bi

et al.

Science Bulletin, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Pyrrolopyrrole Cyanine-Based Polymer with Superior Multifunctionality for Boosting Cancer Phototheranostics DOI
Xue Meng, Yingnan Xu, Yuan Zhang

et al.

ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1431 - 1439

Published: March 19, 2025

Molecular agents with exceptional multifunctionality are highly sought for phototheranostic applications. Herein we present a high-performance polymer near-infrared II (NIR-II) fluorescence and photoacoustic (PA) imaging-guided mild photothermal therapy (mPTT) of tumors. We synthesize series semiconducting polymers based on pyrrolopyrrole cyanine, identifying that P(P-T) exhibits large mass extinction coefficient (139 L g–1 cm–1), excellent performance, bright NIR-II fluorescence, PA imaging signals, making it among the highest-performing in these properties. A tumor-targeting agent was developed by coencapsulating heat shock protein (HSP) inhibitor camouflaging M1 macrophage membranes. The integration enables comprehensive tumor site delineation, guiding subsequent therapeutic intervention. In 4T1 tumor-bearing mice, synergistic effect mPTT under low-power 808 nm laser irradiation, combined HSP inhibition, resulted significant suppression. This work offers valuable insights designing advanced agents.

Language: Английский

Citations

0
Exosome-mediated dual drug delivery of curcumin and methylene blue for enhanced cognitive function and mechanistic elucidation in Alzheimer’s disease therapy DOI Creative Commons
Dongxin Yang,

Zhishan Deng,

Hai Zhou

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: March 24, 2025

Alzheimer’s disease (AD) is one of the neurodegenerative disorders, characterized by complex pathogenic mechanisms, including deposition beta-amyloid protein and hyperphosphorylation Tau protein. There currently a lack effective therapeutic approaches for AD treatment. The aim this study was to design exosomes (EXO) as specifically designed carrier able carry Curcumin (Cur) Methylene Blue (MB) improve cognitive function elucidate its underlying mechanisms. Our results indicated that EXO-Cur+MB inhibited phosphorylation activating AKT/GSK-3β pathway, while reversing dysfunction in mice reducing apoptosis induced okadaic acid (OA). Thus, our suggested would be potential use treatment AD.

Language: Английский

Citations

0
Oxygen Vacancy Piezoelectric Nanosheets Constructed by a Photoetching Strategy for Ultrasound “Unlocked” Tumor Synergistic Therapy DOI

Chenghao Yu,

Yushan Dong, Xingyu Zhu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: 24(26), P. 8008 - 8016

Published: June 24, 2024

Piezoelectric dynamic therapy (PzDT) is an effective method of tumor treatment by using piezoelectric polarization to generate reactive oxygen species. In this paper, two-dimensional Cu-doped BiOCl nanosheets with surface vacancies are produced the photoetching strategy. Under ultrasound, a built-in electric field generated promote electron and hole separation. The separated carriers achieve O

Language: Английский

Citations

4
An Albumin‐Photosensitizer Supramolecular Assembly with Type I ROS‐Induced Multifaceted Tumor Cell Deaths for Photodynamic Immunotherapy DOI Creative Commons
Jingtian Zhang,

Di Jiao,

Xinwen Qi

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Abstract Photodynamic therapy holds great potentials in cancer treatment, yet its effectiveness hypoxic solid tumor is limited by the oxygen‐dependence and insufficient oxidative potential of conventional type II reactive oxygen species (ROS). Herein, study reports a supramolecular photosensitizer, BSA@TPE‐BT‐SCT NPs, through encapsulating aggregation‐enhanced emission photosensitizer bovine serum albumin (BSA) to significantly enhance ROS, particularly less oxygen‐dependent I ROS for photodynamic immunotherapy. The abundant generated NPs induce multiple forms programmed cell death, including apoptosis, pyroptosis, ferroptosis. These multifaceted deaths synergistically facilitate release damage‐associated molecular patterns antitumor cytokines, thereby provoking robust immunity. Both vitro vivo experiments confirmed that elicited immunogenic dendritic maturation, activate T cell, reduce myeloid‐derived suppressor cells, leading inhibition both primary distant tumors. Additionally, BSA@TPE‐BT‐SCP also exhibited excellent performance humanized mice model, evidenced reduction senescent cells among these activated cells. findings advance development photosensitizers unveil important role enhancing immunogenicity.

Language: Английский

Citations

0
Intra or extracellular: The location of piezotronic effect determines the polarization regulation of macrophages for enhanced wound healing DOI

Bo‐Jun Xie,

Shan Lu, Liang Wang

et al.

Nano Energy, Journal Year: 2025, Volume and Issue: unknown, P. 110893 - 110893

Published: March 1, 2025

Language: Английский

Citations

0
Targeting regulated cell death (RCD) in hematological malignancies: Recent advances and therapeutic potential DOI Open Access

Yu Zhang,

Xiangxiang Zhou

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116667 - 116667

Published: May 3, 2024

Regulated cell death (RCD) is a form of that can be regulated by numerous biomacromolecules. Accumulating evidence suggests dysregulated expression and altered localization related proteins in RCD promote the development cancer. Targeting subroutines with pharmacological small-molecule compounds becoming promising therapeutic avenue for anti-tumor treatment, especially hematological malignancies. Herein, we summarize aberrant mechanisms apoptosis, necroptosis, pyroptosis, PANoptosis, ferroptosis In particular, focus on relationship between tumorigenesis, immunotherapy, drug resistance Furthermore, discuss emerging strategies targeting different subroutines. This review aims to significance potential malignancies, along utilization pertinent strategies.

Language: Английский

Citations

3
Amplifying Synergistic Effects of Cuproptosis and Bacterial Membrane Vesicles‐Mediated Photothermal Therapy by Multifunctional Nano‐Biohybrid for Anti‐Tumor Immunotherapy DOI Open Access

Mei‐Ting Niu,

Qian‐Ru Li,

Qian‐Xiao Huang

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract The other functions of bacterial membrane vesicles (BMVs) except serving as immune adjuvants and vaccine platforms are yet to be further explored. This study investigates the photothermal properties Rhodobacter sphaeroides‐derived BMVs (RMVs) beyond their immunostimulatory properties. A multifunctional nano‐biohybrid, termed CuM@RR, is constructed by encapsulating Cu‐based metal–organic framework (CuM) nanoparticles into DSPE‐PEG 2000 ‐RGD‐functionalized RMVs, leveraging functionalization cargo capacity BMVs. ‐RGD modification facilitates targeted delivery CuM@RR tumor sites. CuM core within decomposes in acid microenvironment, releasing Cu 2+ inducing cell cuproptosis. Under 808 nm near‐infrared irradiation, effect‐induced apoptosis synergizes with copper ions overload‐induced cuproptosis, causing irreversible mitochondrial damage cells triggering strong immunogenic death (ICD). released damage‐associated molecular patterns (DAMPs) tumor‐associated antigens (TAAs) during ICD, along inherent immunoadjuvant elicit robust anti‐tumor responses. In vivo experiments confirm that significantly suppresses growth prevents rechallenge without obvious systemic toxicity under synergistic effects therapy, immunotherapy, suggesting great potential this nano‐biohybrid developing safe effective multi‐therapeutic strategies.

Language: Английский

Citations

2