Nanoelectrode‐Mediated Extracellular Electrical Stimulation Directing Dopaminergic Neuronal Differentiation of Stem Cells for Improved Parkinson's Disease Therapy DOI Open Access
Liang Wang,

Yuan Yao,

Bo‐Jun Xie

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract Parkinson's disease (PD) is a neurodegenerative caused by the dysfunction and death of dopaminergic neurons. Neural‐stem‐cell (NSC)‐based therapy promising approach for treatment PD but its therapeutic performance limited low efficiency differentiation NSCs to Although electrical stimulation can promote neuronal differentiation, it not verified whether induce specifically differentiate into Meanwhile, great challenge precisely apply dynamically migrating after transplantation. Here, electrochemically exfoliated graphene nanosheets are designed anchor membrane serve as wireless nanoelectrodes. After anchoring cell membrane, these nanoelectrodes able migrate together with cells extracellular receptors or ion transport channels on transplanted under alternating magnetic field. The nanoelectrode‐mediated induces 38.46% neurons, while percentage only 5.82% without nanoelectrode stimulation. Transplantation anchored effectively improves recovery motor memory ability mice field within 2 weeks.

Language: Английский

Piezoelectric Heterojunctions as Bacteria‐Killing Bone‐Regenerative Implants DOI Creative Commons

Youzhun Fan,

Jinxia Zhai, Zhengao Wang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 25, 2024

Heterojunctions are widely used in energy conversion, environmental remediation, and photodetection, but have not been fully explored regenerative medicine. In particular, piezoelectric heterojunctions never examined tissue regeneration. Here the development of is shown to promote bone regeneration while eradicating pathogenic bacteria through light-cellular force-electric coupling. Specifically, an array (TiO

Language: Английский

Citations

5
First principle study of electronic, magnetic and optical properties of X-doped (X=Fe, Co and Cu) boron nitride nanotubes and its applications DOI
Abinash Thapa, Bikash Sharma, Bibek Chettri

et al.

Applied Physics A, Journal Year: 2025, Volume and Issue: 131(2)

Published: Jan. 27, 2025

Language: Английский

Citations

0
Bone marrow mesenchymal stem cells-derived exosomal miR-24-3p alleviates spinal cord injury by targeting MAPK9 to inhibit the JNK/c-Jun/c-Fos pathway DOI

Dongzi Li,

Xiaoyan Xie, Yuxuan Ou

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: 769, P. 110434 - 110434

Published: April 22, 2025

Language: Английский

Citations

0
The Application of Biomaterial‐Based Spinal Cord Tissue Engineering DOI
L. Ma, Zhen Zhang, Yulei Mu

et al.

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract Advancements in biomaterial‐based spinal cord tissue engineering technology have profoundly influenced regenerative medicine, providing innovative solutions for both organoid development and engineered injury (SCI) repair. In organoids, biomaterials offer a supportive microenvironment that mimics the natural extracellular matrix, facilitating cell differentiation organization advancing understanding of pathophysiology. Furthermore, are essential constructing cords SCI The incorporation with growth factors, fabrication ordered scaffold structures, artificial assemblies critical insights to ensure structural integrity, enhance viability, promote neural regeneration transplantation. summary, this review summarizes contribution organoids progression discusses strategies therapy. These achievements underscore transformative potential improve treatment options accelerate future clinical applications.

Language: Английский

Citations

1
Polylactic acid/chitosan-IKVAV Janus film serving as a dual functional platform for spinal cord injury repair DOI
Liyang Yu,

Haoyong Jin,

Xia He

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(47), P. 21991 - 22000

Published: Jan. 1, 2024

The repair of traumatic spinal cord injury (SCI) remains a challenge due to the non-regenerative nature functional neurons in adults. Neural stem cell (NSC)-based therapy has emerged as promising approach for treatment SCI by replacing damaged with differentiated cells. However, directing neuronal differentiation implanted cells microenvironment is great difficulty, especially considering that generally associated severe fibrotic tissue infiltration, neuron inflammation, and adhesion. Here, we propose dual Janus film capable preventing adhesion promoting SCI. composed layer polylactic acid (PLA) chitosan (CS) grafted IKVAV peptides. PLA prevents invasion tissue, while peptide-grafted CS offers support NSC implantation thus NSCs. When serving dura patch, films seeded NSCs promote recovery motor function regeneration injured rats. This holds promise treating combination therapy.

Language: Английский

Citations

1
Nanoelectrode‐Mediated Extracellular Electrical Stimulation Directing Dopaminergic Neuronal Differentiation of Stem Cells for Improved Parkinson's Disease Therapy DOI Open Access
Liang Wang,

Yuan Yao,

Bo‐Jun Xie

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 20, 2024

Abstract Parkinson's disease (PD) is a neurodegenerative caused by the dysfunction and death of dopaminergic neurons. Neural‐stem‐cell (NSC)‐based therapy promising approach for treatment PD but its therapeutic performance limited low efficiency differentiation NSCs to Although electrical stimulation can promote neuronal differentiation, it not verified whether induce specifically differentiate into Meanwhile, great challenge precisely apply dynamically migrating after transplantation. Here, electrochemically exfoliated graphene nanosheets are designed anchor membrane serve as wireless nanoelectrodes. After anchoring cell membrane, these nanoelectrodes able migrate together with cells extracellular receptors or ion transport channels on transplanted under alternating magnetic field. The nanoelectrode‐mediated induces 38.46% neurons, while percentage only 5.82% without nanoelectrode stimulation. Transplantation anchored effectively improves recovery motor memory ability mice field within 2 weeks.

Language: Английский

Citations

0