The influence of vascular risk factors on cognition among patients over 65 years of age in rural area - preliminary report DOI Creative Commons
Radosław Zachara, Adam Właszczuk, Daria Gendosz de Carrillo

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Background: Hypertension (HTN) and diabetes mellitus (DM) are associated with cognitive impairment dementia. Antihypertensive treatment may improve functioning. Elevated blood glucose levels can increase the risk of dementia even in non-DM. Both HTN DM contribute to development Alzheimer’s disease. Aims: The aim this study was assess influence vascular factors on cognition. Methods: conducted south Poland among rural population over 65 years age. 85 patients qualified into were divided groups according presence (n=18), (n=7), or both (n=40). Control group also formed (n=20). Biochemical tests, neurological scales assessment ultrasound examinations conducted. Results: median score for M-ACE scale 3 points lower when coexisted, compared diagnosis solely (25 28 respectively). Considering MMSE results comparable. higher number education correlated better result (median value 11 >25 9 suspected (<22 points) Conclusions: coexistence caused most profound decline functioning patients. Moreover, a protective factor against old Cholesterol uric acid roles still debatable.

Language: Английский

Role of uric acid in neurodegenerative diseases, focusing on Alzheimer and Parkinson disease: A new perspective DOI Creative Commons
Mohammed Alrouji, Hayder M. Al‐kuraishy, Ali I. Al‐Gareeb

et al.

Neuropsychopharmacology Reports, Journal Year: 2024, Volume and Issue: 44(3), P. 639 - 649

Published: July 29, 2024

Abstract Neurodegenerative diseases (NDs) such as Alzheimer disease (AD) and Parkinson (PD) are group of affecting the central nervous system (CNS) characterized by progressive neurodegenerations cognitive impairment. Findings from different studies highlighted beneficial detrimental effects serum uric acid on development progression NDs. Therefore, this mini‐review aims to discuss The neuroprotective effect is mainly related antioxidant which alleviates oxidative stress‐induced neurodegeneration in AD PD. However, long‐term hyperuricemia prompts for Hyperuricemia associated with impairment dementia, gout increases dementia risk. In addition, can cause cerebral vascular injury a risk factor Taken together, relationship between NDs remains conflicting. Hence, preclinical clinical indicated regard.

Language: Английский

Citations

7
Relations between neurometabolism and clinical biomarkers in patients with metabolic disease DOI Creative Commons
Chaochao Chen, Michael J. Tan,

Jiangtao Yin

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: April 15, 2025

The global prevalence of metabolic diseases, including hypertension, type 2 diabetes mellitus (T2DM), gout, and obesity, has significantly increased over the past two decades. brain plays a central role in regulating both human behavior metabolism. Understanding potential connections among these diseases involvement their progression presents an intriguing critical area research. In this study, we analyzed PET-CT images clinical biomarkers from 112 cases 56 T2DM, 11 14 gout. Standardized uptake value ratios (SUVRs) were extracted various regions using Spatial-Normalization-of-Brain-PET-Images (SNBPI) software. SUVRs calculated standard methodology, where mean standardized (SUV) each region interest (ROI) was divided by SUV reference region, that is whole cerebellum. SNBPI tool employed for intensity normalization. Partial correlation analysis conducted to examine relationships between different biomarkers, adjusting sex, age, BMI. Brain network connectivity assessed Permutation_IHEP software visualized with BrainNet Viewer. Our results indicate most decreased patients hypertension or T2DM but obesity Specifically, associated blood pressure correlated uric acid, creatinine, potassium, apolipoprotein B. related glucose triglycerides cholinesterase. BMI-related urea nitrogen, aspartate aminotransferase, alkaline phosphatase. gout fasting glucose, glutamic oxalacetic transaminase, total bilirubin, Furthermore, reduced findings suggest acid may negatively relate levels, while lipid levels be positively other. Gout appears distinct other offer protective effect on function. right superior parietal gyrus implicated impaired renal function during hypertension. left precentral bilateral middle frontal gyri dyslipidemia development atherosclerotic cardiovascular disease T2DM. conclusion, our study highlights suggests possible regulatory roles specific conditions. These insights could pave way novel therapeutic strategies targeting metabolism management diseases.

Language: Английский

Citations

0
Comment on: “Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence” DOI Creative Commons
Zain Ali Nadeem, Abdulqadir J. Nashwan

Brain and Behavior, Journal Year: 2024, Volume and Issue: 14(2)

Published: Feb. 1, 2024

Dear Editor, We read with great interest the recent systematic review and meta-analysis by Wang et al. (2023), which explored association of hyperuricemia gout Alzheimer's disease. The authors observed a negative correlation between two conditions detected hazard ratio 0.69 (95% confidence interval 0.66–0.72). concluded that there was moderate risk heterogeneity (I2 = 93%), they attributed to regional differences. In an otherwise excellent paper, we find methodological inaccuracies might have overestimated effect. First, used fixed-effect model for their meta-analysis. ignores any may be present gives more precise effect estimate, but it not generalizable. cases where considerable is present, random effects can used. This takes into account different populations on individual studies were conducted (Deeks al., 2019). Second, funnel plots, Begg's test, Egger's test assess publication bias. As rule thumb, Cochrane Handbook Systematic Reviews Interventions recommends against using tests plot asymmetry when number included less than 10 (Page Additionally, visual inspection quite subjective prone errors (Terrin 2005). Doi Luis Furuya–Kanamori index are sensitive bias (Furuya-Kanamori 2018) do suffer from difficulty in interpretation as plots. commend searching both Medline Embase, recommended (Lefebvre urge colleagues impact model—despite attributing country origin—discuss its implications generalizability results, reassess Zain Ali Nadeem: Writing—original draft; writing—review editing. Abdulqadir J. Nashwan: Writing—review this article funded Qatar National Library. Hamad Medical Corporation Open Access publishing facilitated Library, part Wiley - Library agreement. declare no conflicts interest. peer history available at https://publons.com/publon/10.1002/brb3.3424. Data sharing applicable datasets generated or analyzed during current study.

Language: Английский

Citations

3
Gout/hyperuricemia reduces the risk of Alzheimer's disease: A meta‐analysis based on latest evidence DOI Creative Commons
Long Wang,

Zheng Tan,

Fu‐Yu Wang

et al.

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(10)

Published: Sept. 4, 2023

Abstract Objective Previous studies have found the potential role of gout or hyperuricemia in subsequent development Alzheimer's disease (AD) but reported inconsistent results. We conducted current meta‐analysis to evaluate whether an association exists between gout/ and AD. Methods systematically searched PubMed EMBASE for published cohort that measured risk AD subject with up May 20, 2023. Data extraction was employed by two authors independently. Rev Man 5.3 Stata 15.0 software were used calculate relative ratio (RR) hazard (HR) including studies. Subgroup analysis performed assess sources heterogeneity. A random‐effects model adopted when heterogeneity present. The funnel plot, Begg's test, Egger's test publication bias. Results After rigorous screening, seven eligible included final analyses. Pooled results indicated decreases (RR: 0.69, 95% CI: 0.64∼0.72), a high 93%. analyses showed regional distribution source tests as well visual inspection plot suggested no bias Conclusion findings might protective effect against This negative correlation should be verified more due existence substantial

Language: Английский

Citations

6
Sex difference in the associations among hyperuricemia with self-reported peptic ulcer disease in a large Taiwanese population study DOI Creative Commons

Chi-Sheng Yang,

Jiun‐Hung Geng, Peï-Yu Wu

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: June 10, 2024

Background Hyperuricemia may play a role in various systemic diseases. However, few studies have investigated the relationship between hyperuricemia and risk of peptic ulcer disease (PUD). Therefore, this population-based study, we enrolled over 120,000 participants from Taiwan Biobank (TWB) examined factors for self-reported PUD. In addition, sex differences association Methods Data 121,583 were obtained TWB. Male with serum uric acid level &gt;7 mg/dl female &gt;6 classified as having hyperuricemia. Details PUD by questionnaire. The male was using multivariable logistic regression analysis. Results overall prevalence 14.6%, higher incidence males (16.5%) compared to females (13.5%). After adjustment, [vs. sex; odds ratio (OR) = 1.139; 95% confidence interval (CI) 1.084–1.198; p &lt; 0.001], (OR 0.919; CI 0.879–0.961; 0.001) significantly associated Further, significant interaction found on ( 0.004). low 0.890; 0.837–0.947; but not 0.139). Conclusion than participants. males, females. Further are needed clarify mechanisms behind these observations verify potential protective development

Language: Английский

Citations

0
The influence of vascular risk factors on cognition among patients over 65 years of age in rural area - preliminary report DOI Creative Commons
Radosław Zachara, Adam Właszczuk, Daria Gendosz de Carrillo

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Background: Hypertension (HTN) and diabetes mellitus (DM) are associated with cognitive impairment dementia. Antihypertensive treatment may improve functioning. Elevated blood glucose levels can increase the risk of dementia even in non-DM. Both HTN DM contribute to development Alzheimer’s disease. Aims: The aim this study was assess influence vascular factors on cognition. Methods: conducted south Poland among rural population over 65 years age. 85 patients qualified into were divided groups according presence (n=18), (n=7), or both (n=40). Control group also formed (n=20). Biochemical tests, neurological scales assessment ultrasound examinations conducted. Results: median score for M-ACE scale 3 points lower when coexisted, compared diagnosis solely (25 28 respectively). Considering MMSE results comparable. higher number education correlated better result (median value 11 >25 9 suspected (<22 points) Conclusions: coexistence caused most profound decline functioning patients. Moreover, a protective factor against old Cholesterol uric acid roles still debatable.

Language: Английский

Citations

0