Personality traits in patients with multiple sclerosis: their association with nicotine dependence and polypharmacy DOI Creative Commons
Janina Meißner, Niklas Frahm,

Michael Hecker

et al.

Therapeutic Advances in Neurological Disorders, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 1, 2024

Background: The modifiable risk factor exerting the most substantial influence on development and disease course of multiple sclerosis (MS) is cigarette smoking. Furthermore, smoking associated with a higher suffering from one or more comorbidities potentially contributes to polypharmacy. We aimed use personality tests explore health-promoting harmful patient characteristics. Objective: To investigate two important factors influencing MS – degree dependence status polypharmacy in association traits. Design: This bicentric, cross-sectional study. Methods: collected sociodemographic, clinical medical data patients ( n = 375) at German neurological clinics. participants were asked complete NEO Five-Factor Inventory (NEO-FFI) Temperament Character Inventory-Revised (TCI-R). Relationships between variables examined using correlation analyses, differences groups linear models. Current smokers also Fagerström questionnaire categorize them into mild, moderate severe dependence. Results: In our sample, 67.5% women, mean age was 48.1 years. had median Expanded Disability Status Scale 3.0 duration 10 Patients average significantly neuroticism score NEO-FFI compared those mild scores than without. extraversion scale NEO-FFI, lower average. Significant found when analysing TCI-R heavy dependence, for harm avoidance (HA) reward self-directedness (S-D) cooperativeness (CO) various subscales. Polypharmacy HA self-transcendence. showed values without individual subscales dimensions persistence, S-D CO. Conclusion: Using we able show that detrimental trait protective relation nicotine addition, evaluation high as well low CO common With this knowledge, can be understood context characteristics targeted treatment counselling provided.

Language: Английский

Personality Profile and Traits in Neurological Diseases DOI

Mei‐Ling Sharon Tai,

Jun Kit Khoo,

Han Lim Chin

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Evaluation of nonmotor symptoms in myasthenia gravis patients DOI Creative Commons
Aysel Tekeşin, Çağla Şişman, Ufuk Emre

et al.

TURKISH JOURNAL OF MEDICAL SCIENCES, Journal Year: 2025, Volume and Issue: 55(1), P. 127 - 139

Published: Feb. 18, 2025

Background/aim: Myasthenia gravis (MG) is chronic autoimmune disorder characterized primarily by muscle weakness and fatigue, due to autoantibodies targeting acetylcholine receptor at neuromuscular junction. In this study, we aimed evaluate non-motor symptoms in myasthenia patients compare them with disease duration, severity clinical features.Materials methods: This prospective study was conducted thirty-five healthy volunteers. Total of 35 patients, 17 women 18 men mean age 52.9±13.6 years constituted patient group. Control group consisted total participants, 23 12 46.9±12.2 years. Patient applied scales MG Foundation America classification, Composite Turkish version Quality Life 15. For functions, both controls; used the inquiry questionnaires evaluating headache, pain, depression, anxiety, sleep, physical activity, cognition, smell taste. Results: Results revealed prevalent diverse patients. Montreal Cognitive Assessment (MoCA) score degree olfactory function cinnamon significantly (p<0.05) lower than control Rate impaired MoCA degree, headache rate, Beck depression score, anxiety Pittsburgh Sleep Index (PSQI) rate poor PSQI higher group.Conclusion: conclusion, our emphasizes importance recognizing managing advocating for multidisciplinary approach care that addresses motor manifestations. By expanding understanding MG's systemic impact exploring new treatment modalities, can improve lives those living complex disorder. Further research needed elucidate pathogenic mechanisms underlying these manifestations, which will be pivotal developing more targeted effective therapeutic strategies.

Language: Английский

Citations

0
Challenges navigating thymectomy with myasthenia gravis: A qualitative study of patient treatment experiences DOI Creative Commons
Malene Missel, René Horsleben Petersen,

Erik Lilja Secher

et al.

Applied Nursing Research, Journal Year: 2025, Volume and Issue: unknown, P. 151961 - 151961

Published: May 1, 2025

Language: Английский

Citations

0
Personality factors in patients with myasthenia gravis: A prospective study DOI Creative Commons
Berit Jordan,

Luise Förster,

Theresa Buchholz

et al.

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(11)

Published: Aug. 22, 2023

In myasthenia gravis (MG), depression and anxiety have frequently been reported as comorbidities. However, little is known about personality characteristics in MG patients. We aimed to characterise traits correlate them with disease severity course.The Big Five Inventory data questionnaire was used investigate 44 patients 45 healthy controls similar age gender. 28 patients, a caregiver also available for patient assessments limit bias associated social desirability patients' responses. Patients were assessed regard premorbid (before manifestation of MG) present condition. addition, scales (Hospital Anxiety Depression Scale Beck Inventory) applied.Compared controls, showed significantly higher levels neuroticism, whereas openness extraversion lower. Agreeableness conscientiousness did not differ between groups. Neuroticism influenced by such generalization weakness, presence thymoma, bulbar involvement well duration. correlated level neuroticism but scores.A profile increased lower may contribute considerably the perception severity. It be related frequent comorbidities depression. Although increased, this characteristic increase during course disease. The indicate that muscle weakness accompanied or even complicated psychological aspects. Therefore, behavioral intervention addition specific pharmacological therapy might particular value.

Language: Английский

Citations

5
Personality traits in patients with multiple sclerosis: their association with nicotine dependence and polypharmacy DOI Creative Commons
Janina Meißner, Niklas Frahm,

Michael Hecker

et al.

Therapeutic Advances in Neurological Disorders, Journal Year: 2024, Volume and Issue: 17

Published: Jan. 1, 2024

Background: The modifiable risk factor exerting the most substantial influence on development and disease course of multiple sclerosis (MS) is cigarette smoking. Furthermore, smoking associated with a higher suffering from one or more comorbidities potentially contributes to polypharmacy. We aimed use personality tests explore health-promoting harmful patient characteristics. Objective: To investigate two important factors influencing MS – degree dependence status polypharmacy in association traits. Design: This bicentric, cross-sectional study. Methods: collected sociodemographic, clinical medical data patients ( n = 375) at German neurological clinics. participants were asked complete NEO Five-Factor Inventory (NEO-FFI) Temperament Character Inventory-Revised (TCI-R). Relationships between variables examined using correlation analyses, differences groups linear models. Current smokers also Fagerström questionnaire categorize them into mild, moderate severe dependence. Results: In our sample, 67.5% women, mean age was 48.1 years. had median Expanded Disability Status Scale 3.0 duration 10 Patients average significantly neuroticism score NEO-FFI compared those mild scores than without. extraversion scale NEO-FFI, lower average. Significant found when analysing TCI-R heavy dependence, for harm avoidance (HA) reward self-directedness (S-D) cooperativeness (CO) various subscales. Polypharmacy HA self-transcendence. showed values without individual subscales dimensions persistence, S-D CO. Conclusion: Using we able show that detrimental trait protective relation nicotine addition, evaluation high as well low CO common With this knowledge, can be understood context characteristics targeted treatment counselling provided.

Language: Английский

Citations

0