Changes in serum levels of pain mediators in hemiplegic shoulder pain

Brain and Behavior, Journal Year: 2023, Volume and Issue: 13(12)

Published: Oct. 20, 2023

Abstract Objective To provide a new insight into the diagnosis and treatment of hemiplegic shoulder pain (HSP) by investigating changes in serum mediators. Design Cross‐sectional study. Subjects/patients Shoulder group ( n = 34) control 21). Methods Pain‐free mobility, anxiety status, depression were measured passive range motion (PROM), self‐rating scale, scale (SDS), visual analog respectively. The enzyme‐linked immunosorbent assay was used to test mediators, including interleukin (IL)‐1β, IL‐2, IL‐6, IL‐10, nerve growth factor (NGF), tumor necrosis factor‐α (TNF‐α), substance P (SP), calcitonin gene‐related peptide (CGRP), bradykinin (BK), 5‐hydroxytryptamine (5‐HT), prostaglandin E2 (PGE2), lysophosphatidic acid (LPA). Results pain‐free PROM significantly lower than p < .01), SDS index score higher .05). rate spasticity flexor elbow muscles is .01). CGRP, IL‐2 upregulated compared with whereas NGF, TNF‐α, 5‐HT, PGE2, SP, LPA, BK, IL‐1β decreased Conclusion Patients HSP have risk joint mobility disorders depression; may be an important development pain; CGRP thought major mediator HSP, not inflammatory.

Language: Английский

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Immune response and cytokine profiles in post-laminectomy pain syndrome: comparative analysis after treatment with intrathecal opioids, oral opioids, and non-opioid therapies

Inflammopharmacology, Journal Year: 2024, Volume and Issue: 32(5), P. 3295 - 3309

Published: July 22, 2024

Language: Английский

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Effect of postoperative hydrocodone analgesia on inflammatory factors, NSE levels, and cognitive function in elderly patients undergoing hip arthroplasty

American Journal of Translational Research, Journal Year: 2024, Volume and Issue: 16(9), P. 4612 - 4622

Published: Jan. 1, 2024

To explore the effect of postoperative hydrocodone analgesia on inflammatory factors, NSE levels, and cognitive function in elderly patients undergoing hip arthroplasty.

Language: Английский

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Epidural injection of varying doses of capsaicin alleviates inflammatory pain in rats via the TLR4/AKT/NF-κB pathway

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 17, 2024

Capsaicin (CAP) induces transient pain sensation by activating receptor potential vanilloid-1 (TRPV1). However, the initial neuronal excitation induced CAP is followed a prolonged refractory period, resulting in long-lasting analgesia. Although effects of on microglia dorsal root ganglion neuropathic disorders have been reported, regulatory pathways remain poorly defined. A chronic model was established via plantar injection complete Freund's adjuvant (CFA), and different doses were administered to rats. Pain behavior, expression pain-related factors, protein TRPV1 nerve cells, inflammatory activation evaluated. In vitro experiments conducted explore migration ability microglia, cytokines pathway proteins, intracellular calcium concentration under CAP. Different alleviated rats, reduced inhibited microglia; however, high particularly effective improving pain. confirmed that reduces secretion inhibition TLR4/AKT/NF-κB signaling pathway. This mechanism injury apoptosis TRPV1, influx ions cells. responses dose-dependent manner inhibiting pathway, which consequently cells

Language: Английский

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Mucus-inspired lubricative antibacterial coating to reduce airway complications in an intubation cynomolgus monkey model

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: unknown, P. 110559 - 110559

Published: Oct. 1, 2024

Language: Английский

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