The effect of sertraline-selenium combination on cardiac contractile strength DOI Open Access
Hatice Solak, Z. Işık Solak Görmüş, Raviye Özen Koca

et al.

The European Research Journal, Journal Year: 2025, Volume and Issue: 11(2), P. 143 - 150

Published: Feb. 4, 2025

Objectives: Individuals with myocardial infarction (MI) frequently exhibit a heightened prevalence of depression, which elevates the likelihood negative cardiovascular outcomes. This study aimed to assess potential synergistic effects sertraline, an antidepressant utilised for prevention and treatment depression commonly associated cardiac disorders, selenium, antioxidant trace element, on atrial contraction force. Methods: Thirty-two adult male Wistar albino rats were randomly allocated into four groups. Atrial strips positioned in organ bath, tension was calibrated 2 g. In control group, isometric contractions elicited using 10-3 M adrenaline, documented. Sertraline (S) incrementally administered S group dosages 0.01 mM, 0.1 1 mM. Selenium (Se) Group, selenium at concentrations 0.1, 1, 2, 4 mmol/L. S+Se cumulative (0.01 mM) Se (0.1, 4) mmol/L fifteen-minute intervals. Results: The had statistically significant reduction compared group. Statistically substantial inhibition noted relative (P=0.035 P=0.02, respectively). Conclusions: According results our study, sertraline-selenium combination showed effect by Ca2+ channels rat atrium. Additional research is needed elucidate mechanism action used that often accompanies effective element properties.

Language: Английский

Natural products target pyroptosis for ameliorating neuroinflammation: A novel antidepressant strategy DOI
Guangheng Zhang,

Ruirui Shang,

Xia Zhong

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 138, P. 156394 - 156394

Published: Jan. 14, 2025

Language: Английский

Citations

0
The effect of sertraline-selenium combination on cardiac contractile strength DOI Open Access
Hatice Solak, Z. Işık Solak Görmüş, Raviye Özen Koca

et al.

The European Research Journal, Journal Year: 2025, Volume and Issue: 11(2), P. 143 - 150

Published: Feb. 4, 2025

Objectives: Individuals with myocardial infarction (MI) frequently exhibit a heightened prevalence of depression, which elevates the likelihood negative cardiovascular outcomes. This study aimed to assess potential synergistic effects sertraline, an antidepressant utilised for prevention and treatment depression commonly associated cardiac disorders, selenium, antioxidant trace element, on atrial contraction force. Methods: Thirty-two adult male Wistar albino rats were randomly allocated into four groups. Atrial strips positioned in organ bath, tension was calibrated 2 g. In control group, isometric contractions elicited using 10-3 M adrenaline, documented. Sertraline (S) incrementally administered S group dosages 0.01 mM, 0.1 1 mM. Selenium (Se) Group, selenium at concentrations 0.1, 1, 2, 4 mmol/L. S+Se cumulative (0.01 mM) Se (0.1, 4) mmol/L fifteen-minute intervals. Results: The had statistically significant reduction compared group. Statistically substantial inhibition noted relative (P=0.035 P=0.02, respectively). Conclusions: According results our study, sertraline-selenium combination showed effect by Ca2+ channels rat atrium. Additional research is needed elucidate mechanism action used that often accompanies effective element properties.

Language: Английский

Citations

0