Vitamin D Status Determines Metformin Action on Gonadotropin Levels in Postmenopausal Women with Subclinical Hyperthyroidism DOI Creative Commons
Robert Krysiak, Karolina Kowalcze, Witold Szkróbka

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 442 - 442

Published: March 30, 2025

Background/Objectives: The gonadotropin-lowering effects of metformin were found to be more pronounced in the case coexisting hyperthyroidism and absent patients with hypovitaminosis D. Thus, aim current study was determine whether vitamin D status determines pituitary individuals thyroid hyperfunction elevated gonadotropin levels. Methods: This prospective cohort included three matched groups postmenopausal women prediabetes: 25-hydroxyvitamin levels between 50 75 nmol/L (uncompensated insufficiency), 150 receiving exogenous calciferol due previously diagnosed deficiency/insufficiency (compensated deficiency/insufficiency), calciferol-naïve subjects (the control group). Over entire period (six months), all treated metformin. At beginning at end this study, we determined D, glucose homeostasis markers, gonadotropins, estradiol, progesterone, TSH, free hormones, prolactin, ACTH, IGF-1. Results: Before treatment, except for levels, there no between-group differences investigated markers. In groups, reduced plasma glucose, HOMA1-IR, glycated hemoglobin, FSH, but these both normal than uncompensated insufficiency. decrease LH concentration observed only compensated group. There baseline follow-up remaining hormones. impact on concentrations positively correlated their values, hormone metformin-induced changes HOMA1-IR. Conclusions: Our findings suggest that low impairs hyperthyroidism.

Language: Английский

Vitamin D Status Determines Metformin Action on Gonadotropin Levels in Postmenopausal Women with Subclinical Hyperthyroidism DOI Creative Commons
Robert Krysiak, Karolina Kowalcze, Witold Szkróbka

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 442 - 442

Published: March 30, 2025

Background/Objectives: The gonadotropin-lowering effects of metformin were found to be more pronounced in the case coexisting hyperthyroidism and absent patients with hypovitaminosis D. Thus, aim current study was determine whether vitamin D status determines pituitary individuals thyroid hyperfunction elevated gonadotropin levels. Methods: This prospective cohort included three matched groups postmenopausal women prediabetes: 25-hydroxyvitamin levels between 50 75 nmol/L (uncompensated insufficiency), 150 receiving exogenous calciferol due previously diagnosed deficiency/insufficiency (compensated deficiency/insufficiency), calciferol-naïve subjects (the control group). Over entire period (six months), all treated metformin. At beginning at end this study, we determined D, glucose homeostasis markers, gonadotropins, estradiol, progesterone, TSH, free hormones, prolactin, ACTH, IGF-1. Results: Before treatment, except for levels, there no between-group differences investigated markers. In groups, reduced plasma glucose, HOMA1-IR, glycated hemoglobin, FSH, but these both normal than uncompensated insufficiency. decrease LH concentration observed only compensated group. There baseline follow-up remaining hormones. impact on concentrations positively correlated their values, hormone metformin-induced changes HOMA1-IR. Conclusions: Our findings suggest that low impairs hyperthyroidism.

Language: Английский

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