Carbon Fiber-Mediated Electrospinning Scaffolds Can Conduct Electricity for Repairing Defective Tendon DOI
Xiao Yu,

Genbin Wu,

Pengfei Cai

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(39), P. 52104 - 52115

Published: Sept. 17, 2024

Partial or complete rupture of the tendon can damage collagen structure, resulting in disruption electrical signal pathway. It is a great challenge to reconstruct original pathway and promote regeneration functional recovery defective tendon. In this study, carbon fiber-mediated electrospinning scaffolds were fabricated by wrapping conductive, high-strength, loose single-bundle fibers with nanofiber membranes. Due presence membranes, maximum tensile force was 2.4 times higher than that fibers, while providing excellent temporal spatial prerequisites for tenocytes adapt stimulation accelerate proliferation expression. The diameter fiber monofilaments used study 5.07 ± 1.20 μm, which matched collagen, allowing quickly establishing connection between tissue scaffold, better promoting rabbit Achilles defect repair model, scaffold almost filled compared nonconductive polyethylene glycol terephthalate scaffold. Transcriptome sequencing revealed fibromodulin tenomodulin expression upregulated, their related proteoglycans glycosaminoglycan binding proteins pathways enhanced, could regulate TGF-β signaling optimize extracellular matrix assembly, thus repair. Therefore, makes up shortage conductive repairing defects, revealing potential impact conductivity on new approach future clinical studies.

Language: Английский

Conducting polymer scaffolds: a new frontier in bioelectronics and bioengineering DOI Creative Commons
Rasha A. Nasser, Sagar S. Arya, Khulood H. Alshehhi

et al.

Trends in biotechnology, Journal Year: 2024, Volume and Issue: 42(6), P. 760 - 779

Published: Jan. 5, 2024

Conducting polymer (CP) scaffolds have emerged as a transformative tool in bioelectronics and bioengineering, advancing the ability to interface with biological systems. Their unique combination of electrical conductivity, tailorability, biocompatibility surpasses capabilities traditional nonconducting while granting them access realm bioelectronics. This review examines recent developments CP scaffolds, focusing on material device advancements, well their interplay We highlight applications for monitoring, tissue stimulation, drug delivery discuss perspectives challenges currently faced ultimate translation clinical implementation.

Language: Английский

Citations

11
A Review of Advanced Hydrogel Applications for Tissue Engineering and Drug Delivery Systems as Biomaterials DOI Creative Commons
Hoon Choi, Wan-Sun Choi,

Jin-Oh Jeong

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 693 - 693

Published: Oct. 25, 2024

Hydrogels are known for their high water retention capacity and biocompatibility have become essential materials in tissue engineering drug delivery systems. This review explores recent advancements hydrogel technology, focusing on innovative types such as self-healing, tough, smart, hybrid hydrogels, each engineered to overcome the limitations of conventional hydrogels. Self-healing hydrogels can autonomously repair structural damage, making them well-suited applications dynamic biomedical environments. Tough designed with enhanced mechanical properties, enabling use load-bearing cartilage regeneration. Smart respond external stimuli, including changes pH, temperature, electromagnetic fields, ideal controlled release tailored specific medical needs. Hybrid made from both natural synthetic polymers, combine bioactivity resilience, which is particularly valuable complex tissues. Despite these innovations, challenges optimizing biocompatibility, adjusting degradation rates, scaling up production remain. provides an in-depth analysis emerging technologies, highlighting transformative potential while outlining future directions development applications.

Language: Английский

Citations

10
Electroactive poly(vinylidene fluoride-trifluoroethylene)/graphene composites for cardiac tissue engineering applications DOI Creative Commons
R.M. Meira, Sylvie Ribeiro, Igor Irastorza

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 663, P. 73 - 81

Published: Feb. 19, 2024

Electroactive materials are increasingly being used in strategies to regenerate cardiac tissue. These materials, particularly those with electrical conductivity, actively recreate the electromechanical nature of In present work, we describe a novel combination poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)), highly electroactive polymer, graphene (G), exhibiting high conductivity. G/P(VDF-TrFE) films have been characterized terms topographical, physico-chemical, mechanical, electrical, and thermal properties, studied response cardiomyocytes adhering them. The results indicate that crystallinity wettability composites remain almost unaffected after G incorporation. turn, surface roughness, Young modulus, electric properties higher G/P(VDF-TrFE). Finally, biocompatible able support cardiomyocyte adhesion proliferation, treated ones, demonstrating suitability these for tissue engineering applications.

Language: Английский

Citations

9
Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine DOI
Marzieh Ramezani Farani, Iman Zare,

Mojdeh Mirshafiei

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160852 - 160852

Published: Feb. 1, 2025

Language: Английский

Citations

1
Applications of Stimuli-Responsive Hydrogels in Bone and Cartilage Regeneration DOI Creative Commons

Xiaoqi Ni,

Xin Xing,

Yunfan Deng

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 982 - 982

Published: March 18, 2023

Bone and cartilage regeneration is an area of tremendous interest need in health care. Tissue engineering a potential strategy for repairing regenerating bone defects. Hydrogels are among the most attractive biomaterials tissue engineering, mainly due to their moderate biocompatibility, hydrophilicity, 3D network structure. Stimuli-responsive hydrogels have been hot topic recent decades. They can respond external or internal stimulation used controlled delivery drugs engineering. This review summarizes current progress use stimuli-responsive regeneration. The challenges, disadvantages, future applications briefly described.

Language: Английский

Citations

20
Carbon nanomaterials: Revolutionizing biomedical applications with promising potential DOI Creative Commons

J. Nandhini,

Karthikeyan Elumalai, Sivakumar Manickam

et al.

Nano Materials Science, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

Citations

8
Evaluation of Advanced Nanomaterials for Cancer Diagnosis and Treatment DOI Creative Commons
N Ndlovu, W. B. Mdlalose, Bulelwa Ntsendwana

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 473 - 473

Published: March 28, 2024

Cancer is a persistent global disease and threat to the human species, with numerous cases reported every year. Over recent decades, steady but slowly increasing mortality rate has been observed. While many attempts have made using conventional methods alone as theragnostic strategy, they yielded very little success. Most of shortcomings such can be attributed high demands industrial growth ever-increasing environmental pollution. This requires some high-tech biomedical interventions other solutions. Thus, researchers compelled explore alternative methods. brought much attention nanotechnology applications, specifically magnetic nanomaterials, sole or conjugated The exponential nanomaterials overlapping applications in various fields due their potential properties, which depend on type synthesis route used. Either top-down bottom-up strategies synthesize types NPs. only branches out one method, i.e., physical, two methods, chemical biological syntheses. review highlights techniques, nanoparticle properties each technique produces, use field, more for cancer. Despite evident drawbacks, success achieved furthering complex cancer stages locations unmatched.

Language: Английский

Citations

7
Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights DOI Creative Commons
Zahra Razavi, Simin Farokhi, Golnaz Mahmoudvand

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Dec. 12, 2024

Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival quality of life for this patient population, extensive efforts being made establish effective therapeutic modalities. New treatment options needed, it seems. addition treating diseases, cell therapy is one the most promising medical platforms. One approaches in area stem therapy. biology, multipotent cells pluripotent divided into two types. There evidence that could be used as a approach based on multiple lines evidence. The effectiveness therapies humans has been studied several clinical trials. spite challenges associated with therapy, appears resolving them may lead disease patients. This an approach. By mounting these biological scaffolds, their effect can enhanced.

Language: Английский

Citations

7
Advances in nanobased platforms for cardiovascular diseases: Early diagnosis, imaging, treatment, and tissue engineering DOI Creative Commons
Laleh Shariati, Yasaman Esmaeili, Ilnaz Rahimmanesh

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 116933 - 116933

Published: Aug. 29, 2023

Language: Английский

Citations

16
Recent advances in biofabrication strategies based on bioprinting for vascularized tissue repair and regeneration DOI Creative Commons
Fei Xing, Jiawei Xu, Peiyun Yu

et al.

Materials & Design, Journal Year: 2023, Volume and Issue: 229, P. 111885 - 111885

Published: March 31, 2023

Vascularization plays a crucial role in transporting and exchanging nutrients oxygen between implanted grafts with the host tissue. In biofabrication of grafts, remodeling vascular networks can accelerate vascularized tissue repair regeneration. Given heterogeneity tissues, traditional scaffold manufacturing techniques cannot effectively achieve various scales vitro vivo biomimetic. recent years, 3D bioprinting technologies have been widely used fabricating for regeneration due to their shape customizability, simple procedure, reproducibility, precise multi-dimensional control. With rapid development technologies, bioprinting-based strategies gradually applied construction tissues. Based on this background, our study aimed review advances, challenges, future perspectives based The techniques, bioinks, seed cells, growth factors were also enrolled review. addition, history, vessel formation mechanism, histology discussed.

Language: Английский

Citations

15