Urological
cancers
are
among
the
most
common
malignancies
around
world.
In
particular,
bladder
cancer
severely
threatens
human
health
due
to
its
aggressive
and
heterogeneous
nature.
Various
therapeutic
modalities
have
been
considered
for
treatment
of
although
prognosis
remains
unfavorable.
It
is
perceived
that
depends
on
an
interdisciplinary
approach
combining
biology
engineering.
The
nanotechnological
approaches
introduced
in
various
cancers,
especially
cancer.
current
review
aims
emphasize
highlight
possible
applications
nanomedicine
eradication
tumor.
Nanoparticles
can
improve
efficacy
drugs
therapy
through
elevating
their
bioavailability.
potential
genetic
tools
such
as
siRNA
miRNA
gene
expression
regulation
be
boosted
using
nanostructures
by
facilitating
internalization
accumulation
at
tumor
sites
cells.
provide
photodynamic
photothermal
ROS
overgeneration
hyperthermia,
respectively,
suppression
Furthermore,
remodeling
microenvironment
infiltration
immune
cells
purpose
immunotherapy
achieved
cargo-loaded
nanocarriers.
Nanocarriers
mainly
internalized
endocytosis,
proper
design
smart
nanoparticles
pH-,
redox-,
light-responsive
nanocarriers
importance
targeted
therapy.
Bladder
biomarkers
detected
timely
diagnosis
patients.
Based
site,
they
employed
imaging.
clinical
translation
challenges
also
covered
review.
Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
187, P. 106553 - 106553
Published: Nov. 16, 2022
Cancer
progression
results
from
activation
of
various
signaling
networks.
Among
these,
PI3K/Akt
contributes
to
proliferation,
invasion,
and
inhibition
apoptosis.
Hepatocellular
carcinoma
(HCC)
is
a
primary
liver
cancer
with
high
incidence
rate,
especially
in
regions
prevalence
viral
hepatitis
infection.
Autoimmune
disorders,
diabetes
mellitus,
obesity,
alcohol
consumption,
inflammation
can
also
lead
initiation
development
HCC.
The
treatment
HCC
depends
on
the
identification
oncogenic
factors
that
tumor
cells
develop
resistance
therapy.
present
review
article
focuses
role
progression.
Activation
promotes
glucose
uptake,
favors
glycolysis
increases
cell
proliferation.
It
inhibits
both
apoptosis
autophagy
while
promoting
survival.
stimulates
epithelial-to-mesenchymal
transition
(EMT)
matrix-metalloproteinase
(MMP)
expression
during
metastasis.
In
addition
increasing
colony
formation
capacity
facilitating
spread
cells,
angiogenesis.
Therefore,
silencing
prevents
aggressive
behavior.
confer
drug
resistance,
particularly
sorafenib,
decreases
radio-sensitivity
cells.
Anti-cancer
agents,
like
phytochemicals
small
molecules
suppress
by
limiting
Being
upregulated
tissues
clinical
samples,
be
used
as
biomarker
predict
patients'
response
Abstract
Poly(lactic‐
co
‐glycolic
acid)
(PLGA)
nanoparticles
(NPs)
are
commonly
used
for
drug
delivery
because
of
their
favored
biocompatibility
and
suitability
sustained
controlled
release.
To
prolong
NP
circulation
time,
enable
target‐specific
overcome
physiological
barriers,
NPs
camouflaged
in
cell
membranes
have
been
developed
evaluated
to
improve
delivery.
Here,
we
discuss
recent
advances
membrane‐coated
PLGA
NPs,
preparation
methods,
application
cancer
therapy,
management
inflammation,
treatment
cardiovascular
disease
control
infection.
We
address
the
current
challenges
highlight
future
research
directions
needed
effective
use
membrane‐camouflaged
NPs.
ACS Applied Bio Materials,
Journal Year:
2023,
Volume and Issue:
6(2), P. 784 - 792
Published: Jan. 24, 2023
Radiation
therapy
has
demonstrated
promising
effectiveness
against
several
types
of
cancers.
X-ray
radiation
can
be
made
further
effective
by
utilizing
nanoparticles
high-atomic-number
(high-Z)
materials
that
act
as
radiosensitizers.
Here,
in
purpose
maximizing
the
within
tumors,
bovine
serum
albumin
capped
gadolinium
oxide
and
gold
(Gd2O3@BSA-Au
NPs)
are
developed
a
bimetallic
radiosensitizer.
In
this
study,
we
incorporate
two
high-Z-based
nanoparticles,
Au
Gd,
single
nanoplatform.
The
radiosensitizing
ability
was
assessed
with
series
vitro
tests,
following
evaluation
vivo
breast
cancer
murine
model.
Enhanced
tumor
suppression
is
observed
group
received
after
administration
Gd2O3@BSA-Au
NPs.
As
result,
efficacy
significantly
improved
applying
NPs
under
irradiation,
evidenced
studies
evaluating
cell
viability,
proliferation,
reactive
oxygen
species
production,
anti-tumor
effect.
