Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
We
report
the
application
of
organoiridium
complexes
as
catalytic
agents
for
detoxification
biogenic
reactive
aldehyde
species
(RASP),
which
are
implicated
in
pathogenesis
neurodegenerative
disorders.
show
that
Ir
functionalized
with
phosphonium
cations
localize
selectively
mitochondria
and
have
better
cellular
retention
compared
to
their
parent
species.
In
a
cell
model
Parkinsonism,
mitochondria-targeted
iridium
catalysts
exhibited
superior
protecting
abilities
longer-lasting
effects
(up
6
d)
than
conventional
RASP
scavengers,
failed
be
effective
beyond
24
h.
Our
biological
assays
indicate
treatment
compounds
led
reduction
oxygen
levels
while
partially
preserving
native
mitochondrial
membrane
potential
NAD
Journal of Medicinal Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 3, 2025
We
report
the
application
of
organoiridium
complexes
as
catalytic
agents
for
detoxification
biogenic
reactive
aldehyde
species
(RASP),
which
are
implicated
in
pathogenesis
neurodegenerative
disorders.
show
that
Ir
functionalized
with
phosphonium
cations
localize
selectively
mitochondria
and
have
better
cellular
retention
compared
to
their
parent
species.
In
a
cell
model
Parkinsonism,
mitochondria-targeted
iridium
catalysts
exhibited
superior
protecting
abilities
longer-lasting
effects
(up
6
d)
than
conventional
RASP
scavengers,
failed
be
effective
beyond
24
h.
Our
biological
assays
indicate
treatment
compounds
led
reduction
oxygen
levels
while
partially
preserving
native
mitochondrial
membrane
potential
NAD
