Bioinspired Hydrogel for Sustained Minocycline Release: A Superior Periodontitis Solution

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101638 - 101638

Published: March 1, 2025

Periodontitis treatment remains challenging due to the limitations of clinical medication therapies, including drug cytotoxicity, poor retention, immune imbalances, and epithelial barrier damage. Here, inspired by bioisosterism, we develop a dual-network hydrogel-based delivery system (M@PP) with materials structurally similar minocycline (a commonly used medication). The M@PP hydrogel exhibits optimal mechanical strength bioadhesion, ensuring sufficient retention inside periodontal pockets. sustained release minocycline, combined hydrogel's acidic microenvironment antioxidant functional groups, provides excellent biocompatibility, potent antibacterial activity (98.1 % against P. gingivalis), enhanced anti-inflammatory properties. In vivo studies demonstrate that regulates macrophage polarization, upregulates factors, promotes expression junction-related cytokines. Additionally, activates pro-osteogenic mediators, micro-CT analysis revealing increased trabecular bone density, thickness, reconstruction. RNA sequencing further uncovers its therapeutic mechanisms, highlighting bacterial defense, modulation pro-regenerative signaling. These benefits create favorable microenvironment, facilitating restoration alveolar regeneration, achieving superior outcomes compared commercial products. This study presents promising localized strategy for periodontitis biofilm-associated disorders.

Language: Английский

Cell microparticles loaded with pro-inflammatory factors and chloroquine collaborate with mechanical force to facilitate orthodontic tooth movement

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown, P. 113868 - 113868

Published: May 1, 2025

Language: Английский