Cell-specific role of apoptosis in the process of atherosclerosis DOI Creative Commons
Theofilos Kanavos, Effrosyni Birbas

Aging advances., Journal Year: 2025, Volume and Issue: 2(1), P. 21 - 28

Published: March 1, 2025

Atherosclerosis is a chronic disease of the arterial wall characterized by accumulation fatty and fibrous material in intima. It primary cause cardiovascular disease, which associated with high mortality morbidity rates, particularly aging populations. Apoptosis tightly regulated form programmed cell death that eliminates unneeded or harmful cells. Its role process atherosclerosis has been subject numerous recent studies. In this context, impact apoptosis on was comprehensively examined through narrative literature review. The effect depends types involved stage disease. Endothelial apoptosis, exacerbated aging, may disrupt integrity vascular lining thereby facilitate infiltration lipids into subendothelial space promote plaque vulnerability. Evidence suggests smooth muscle cells can inhibit their migration proliferation attenuate formation early but also induce instability thinning cap advanced stages Macrophage plays dual depending its timing as it limit lesion cellularity suppress progression initial while exacerbating necrotic core development vulnerability late stages. Although more studies are required to fully elucidate atherosclerosis, therapeutic manipulation appears be promising strategy for addressing multifactorial

Language: Английский

Apoptosis in Alzheimer’s disease: insight into the signaling pathways and therapeutic avenues DOI
Sneha Kumari,

Rishika Dhapola,

Dibbanti HariKrishnaReddy

et al.

APOPTOSIS, Journal Year: 2023, Volume and Issue: 28(7-8), P. 943 - 957

Published: April 26, 2023

Language: Английский

Citations

128
Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development DOI Creative Commons
Hu Li, Huiqin Li,

Meiting Zi

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10

Published: Feb. 16, 2022

Cellular senescence is a process that leads to state of irreversible cell growth arrest induced by variety intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age have been implicated in various age-related diseases part via expressing the senescence-associated secretory phenotype. Elimination SnCs has potential delay aging, treat extend healthspan. However, once becoming senescent, they are more resistant apoptotic stimuli. Senolytics can selectively eliminate targeting SnC anti-apoptotic pathways (SCAPs). They developed as novel pharmacological strategy diseases. heterogeneity indicates depend on different proteins or for their survival. Thus, better understanding underlying mechanisms resistance will provide new molecular targets development cell-specific broad-spectrum therapeutics clear SnCs. In this review, we discussed latest research progresses challenge senolytic development, described significance regulation apoptosis systematically summarized SCAPs involved

Language: Английский

Citations

90
Programmed Cell Death in Diabetic Nephropathy: A Review of Apoptosis, Autophagy, and Necroptosis DOI
Nour S. Erekat

Medical Science Monitor, Journal Year: 2022, Volume and Issue: 28

Published: Aug. 10, 2022

Diabetic nephropathy is a common complication of type I and II diabetes, in which renal glomeruli are destroyed, resulting damage, proteinuria, hypertension. Apoptosis, autophagy, necroptosis 3 forms programmed cell death that have been implicated the pathogenesis diabetic nephropathy. Apoptosis podocytes leads to glomerular injury podocyte depletion, associated with proteinuria structural damage Additionally, epithelial cells proximal convoluted tubules also undergo apoptosis nephropathy, leading tubular atrophy, causes depletion subsequent formation atubular association loss function. On other hand, insufficiency autophagy has correlated For instance, decreased autophagic activity shown kidney, causing variations function disruption filtration barrier. Furthermore, attenuated demonstrated buildup impaired molecules organelles, normally broken down by proteinuria. Moreover, might key role decline Thus, this article aims review mechanisms effects including roles apoptosis, necroptosis.

Language: Английский

Citations

56
Curcumin derived from medicinal homologous foods: its main signals in immunoregulation of oxidative stress, inflammation, and apoptosis DOI Creative Commons
Ping Hu, Kaiqi Li,

Xiaoxu Peng

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: July 11, 2023

It has been for thousands of years in China known medicinal homologous foods that can be employed both as and medicines to benefit human animal health. These edible herbal materials perform divert roles the regulation metabolic disorders, cancers, immune-related diseases. Curcumin, primary component derived from like curcuma longa rhizome, is reported play vital actions organic activities, such numerous pharmacological functions including anti-oxidative stress, anti-inflammation anti/pro-apoptosis treating various However, potential mechanisms curcumin-derived modulation still need developed attract more attention worldwide. Given these signal pathways are enrolled important bioactive reactions, we collected curcumin's last achievements predominantly on immune-regulation signals with underlying targetable strategies 10 years. This mini-review will helpful accelerate curcumin other extracts use future clinical applications.

Language: Английский

Citations

22
The therapeutic landscape of tauopathies: challenges and prospects DOI Creative Commons
Jeffrey L. Cummings, María Isabel González,

Martyn C. Pritchard

et al.

Alzheimer s Research & Therapy, Journal Year: 2023, Volume and Issue: 15(1)

Published: Oct. 6, 2023

Abstract Tauopathies are a group of neurodegenerative disorders characterized by the aggregation microtubule-associated protein tau. Aggregates misfolded tau believed to be implicated in neuronal death, which leads range symptoms including cognitive decline, behavioral change, dementia, and motor deficits. Currently, there no effective treatments for tauopathies. There four clinical candidates phase III trials 16 II trials. While currently approved, is increasing evidence suggest that various therapeutic approaches may slow progression tauopathies or improve symptoms. This review outlines landscape drugs (indexed through February 28, 2023) target pathology describes drug development as well those discovery preclinical phases. The also contains information on notable programs inactive have been discontinued from development.

Language: Английский

Citations

22
Research progress on multiple cell death pathways of podocytes in diabetic kidney disease DOI Creative Commons
Can Yang, Zhen Zhang,

Jieting Liu

et al.

Molecular Medicine, Journal Year: 2023, Volume and Issue: 29(1)

Published: Oct. 12, 2023

Diabetic kidney disease (DKD) is the main cause of end-stage renal disease, and its clinical manifestations are progressive proteinuria, decreased glomerular filtration rate, failure. The injury death podocytes keys to DKD. Currently, a variety cell modes have been identified in podocytes, including apoptosis, autophagy, endoplasmic reticulum (ER) stress, pyroptosis, necroptosis, ferroptosis, mitotic catastrophe, etc. signaling pathways leading these processes interconnected can be activated simultaneously or parallel. They essential for survival that determine fate cells. With deepening research on mechanism death, more researchers devoted their attention underlying pathologic drug therapy In this paper, we discussed podocyte physiologic role DKD processes. We also provide an overview types specific mechanisms involved each type DKD, as well related targeted methods drugs reviewed. last part discuss complexity potential crosstalk between various which will help improve understanding lay foundation new ideal strategies treatment future.

Language: Английский

Citations

22
Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer’s Disease and Other Neurodegenerative Diseases DOI Open Access
Yang Sun, Sadequl Islam, Makoto Michikawa

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1757 - 1757

Published: Feb. 1, 2024

Presenilin, a transmembrane protein primarily known for its role in Alzheimer’s disease (AD) as part of the γ-secretase complex, has garnered increased attention due to multifaceted functions various cellular processes. Recent investigations have unveiled plethora beyond amyloidogenic role. This review aims provide comprehensive overview presenilin’s diverse roles AD and other neurodegenerative disorders. It includes summary well-known substrates presenilin, such involvement amyloid precursor (APP) processing Notch signaling, along with functions. Additionally, it highlights newly discovered functions, trafficking function, regulation ferritin expression, apolipoprotein E (ApoE) secretion, interaction ApoE Aβ42-to-Aβ40-converting activity ACE. updated perspective underscores evolving landscape presenilin research, emphasizing broader impact established pathways. The incorporation these novel findings accentuates dynamic nature processes, further advancing our comprehension By synthesizing evidence from range studies, this sheds light on intricate web their implications health disease.

Language: Английский

Citations

11
Directly targeting BAX for drug discovery: Therapeutic opportunities and challenges DOI Creative Commons
Zhenwei Zhang, Linghui Hou, Dan Liu

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(6), P. 2378 - 2401

Published: Feb. 10, 2024

For over two decades, the development of B-cell lymphoma-2 (Bcl-2) family therapeutics has primarily focused on anti-apoptotic proteins, resulting in first-in-class drugs called BH3 mimetics, especially for Bcl-2 inhibitor Venetoclax. The pro-apoptotic protein Bcl-2-associated X (BAX) plays a crucial role as executioner mitochondrial regulated cell death, contributing to organismal development, tissue homeostasis, and immunity. dysregulation BAX is closely associated with onset progression diseases characterized by pathologic survival or such cancer, neurodegeneration, heart failure. In addition conducting thorough investigations into physiological modulation BAX, research regulatory mechanisms small molecules identified through biochemical screening approaches prompted identification functional potentially druggable binding sites well diverse all-molecule modulators. This review presents recent advancements elucidating pharmacological identifying BAX. Furthermore, it highlights structural mechanistic insights small-molecule modulators targeting surfaces conformations offering promising avenue developing next-generation apoptosis treat wide range dysregulated death directly

Language: Английский

Citations

9
Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer’s disease DOI Creative Commons
Yanxin Shen, Guimei Zhang,

Chunxiao Wei

et al.

Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(3), P. 613 - 631

Published: March 1, 2024

Alzheimer’s disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, cure for has not yet been found. Oxidative stress mediates excessive oxidative responses, its involvement in pathogenesis as primary or secondary pathological event widely accepted. As member of the selenium-containing antioxidant enzyme family, glutathione peroxidase 4 reduces esterified phospholipid hydroperoxides to maintain cellular redox homeostasis. With discovery ferroptosis, central role anti-lipid peroxidation several diseases, including disease, received widespread attention. Increasing evidence suggests that expression inhibited brain, resulting stress, inflammation, apoptosis, which are closely associated damage disease. Several therapeutic approaches, such small molecule drugs, natural plant products, non-pharmacological treatments, ameliorate cognitive function by promoting enhancing activity. Therefore, upregulation may be promising strategy treatment This review provides overview gene structure, biological functions, regulatory mechanisms 4, discussion on important events related summary advances small-molecule therapies targeting Most prior studies this subject used animal models, relevant clinical lacking. Future trials required validate effects strategies

Language: Английский

Citations

9
Multi-target-directed therapeutic strategies for Alzheimer’s disease: controlling amyloid-β aggregation, metal ion homeostasis, and enzyme inhibition DOI Creative Commons

Jeasang Yoo,

Jimin Lee,

Byeongha Ahn

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This review highlights the potential of multi-target-directed strategies that address amyloid-β aggregation, metal ion dyshomeostasis, and enzyme dysfunction, offering a comprehensive effective approach to treating Alzheimer's disease.

Language: Английский

Citations

1