Aging advances.,
Journal Year:
2025,
Volume and Issue:
2(1), P. 21 - 28
Published: March 1, 2025
Atherosclerosis
is
a
chronic
disease
of
the
arterial
wall
characterized
by
accumulation
fatty
and
fibrous
material
in
intima.
It
primary
cause
cardiovascular
disease,
which
associated
with
high
mortality
morbidity
rates,
particularly
aging
populations.
Apoptosis
tightly
regulated
form
programmed
cell
death
that
eliminates
unneeded
or
harmful
cells.
Its
role
process
atherosclerosis
has
been
subject
numerous
recent
studies.
In
this
context,
impact
apoptosis
on
was
comprehensively
examined
through
narrative
literature
review.
The
effect
depends
types
involved
stage
disease.
Endothelial
apoptosis,
exacerbated
aging,
may
disrupt
integrity
vascular
lining
thereby
facilitate
infiltration
lipids
into
subendothelial
space
promote
plaque
vulnerability.
Evidence
suggests
smooth
muscle
cells
can
inhibit
their
migration
proliferation
attenuate
formation
early
but
also
induce
instability
thinning
cap
advanced
stages
Macrophage
plays
dual
depending
its
timing
as
it
limit
lesion
cellularity
suppress
progression
initial
while
exacerbating
necrotic
core
development
vulnerability
late
stages.
Although
more
studies
are
required
to
fully
elucidate
atherosclerosis,
therapeutic
manipulation
appears
be
promising
strategy
for
addressing
multifactorial
Bioscience Reports,
Journal Year:
2022,
Volume and Issue:
42(12)
Published: Dec. 1, 2022
Cytochrome
c
(cyt
c)
is
an
electron
transporter
of
the
mitochondrial
respiratory
chain.
Upon
permeabilization
outer
membrane,
cyt
released
into
cytoplasm,
where
it
triggers
intrinsic
pathway
apoptosis.
Cytoplasmic
can
further
reach
bloodstream.
Apoptosis
inhibition
one
hallmarks
cancer
and
its
induction
in
tumors
a
widely
used
therapeutic
approach.
correlate
with
decreased
increased
serum
levels
c,
respectively.
The
quantification
useful
monitoring
patient
response
to
chemotherapy,
potential
prognosis
value.
Several
highly
sensitive
biosensors
have
been
developed
for
human
serum.
Moreover,
delivery
exogenous
cytoplasm
cells
effective
approach
inducing
their
Similarly,
several
protein-based
nanoparticle-based
systems
cells.
As
such,
protein
promising
value
therapy.
In
addition,
thermal
stability
be
extended
through
PEGylation
ionic
liquid
storage.
These
processes
could
contribute
enhancing
exploitation
clinical
facilities
limited
refrigeration
conditions.
Here,
I
discuss
these
research
lines
how
timely
conjunction
advance
therapy
prognosis.
Journal of Anesthesia and Translational Medicine,
Journal Year:
2024,
Volume and Issue:
3(2), P. 27 - 35
Published: April 30, 2024
Neurodegenerative
diseases
(NDs)
refer
to
a
group
of
in
which
slow,
continuous
cell
death
is
the
main
pathogenic
event
nervous
system.
Most
NDs
are
characterized
by
cognitive
dysfunction
or
progressive
motor
dysfunction.
Treatments
mainly
target
alleviating
symptoms,
and
most
do
not
have
disease-modifying
drugs.
The
pathogenesis
involves
inflammation
apoptosis
mediated
mitochondrial
Dantrolene,
approved
US
Food
Drug
Administration,
acts
as
RyRs
antagonist
for
treatment
malignant
hyperthermia,
spasticity,
neuroleptic
syndrome,
ecstasy
intoxication
exertional
heat
stroke
with
tolerable
side
effects.
Recently,
dantrolene
has
also
shown
therapeutic
effects
some
NDs.
Its
neuroprotective
mechanisms
include
reduction
excitotoxicity,
neuroinflammation.
In
summary,
can
be
considered
potential
candidate
Future Journal of Pharmaceutical Sciences,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: June 17, 2024
Abstract
Background
Carbazoles
are
an
important
class
of
heterocyclic
aromatic
compounds
that
contain
nitrogen
atom
in
the
ring.
They
have
a
large-conjugated
system,
attractive
“electrical
and
charge-transport
properties”,
ability
to
efficiently
incorporate
different
functional
groups
into
structurally
inflexible
carbazolyl
Main
text
Carbazole
derivative
ECCA
acts
as
anticancer
agent
by
reactivating
P53
molecular
signaling
pathway;
similarly,
some
other
derivatives
carbazole
show
antifungal
activity
acting
on
RAS-MAPK
pathway.
also
their
effect
inflammation
inhibiting
p38
mitogen-activated
protein
kinase
pathway
stopping
conversion
DAXX
ASK-1.
By
modifying
AKT
through
boosting
phosphatase
brain,
they
anti-Alzheimer’s
translocating
GLUT4
these
effective
against
diabetes.
Conclusion
After
exploring
literature
carbazole,
it
was
found
has
immeasurably
great
potential
for
treatment
various
diseases
nucleus
leads
synthesized
which
used
pharmacological
activities.
So
there
is
need
explore
newer
drugs.
Aging advances.,
Journal Year:
2025,
Volume and Issue:
2(1), P. 21 - 28
Published: March 1, 2025
Atherosclerosis
is
a
chronic
disease
of
the
arterial
wall
characterized
by
accumulation
fatty
and
fibrous
material
in
intima.
It
primary
cause
cardiovascular
disease,
which
associated
with
high
mortality
morbidity
rates,
particularly
aging
populations.
Apoptosis
tightly
regulated
form
programmed
cell
death
that
eliminates
unneeded
or
harmful
cells.
Its
role
process
atherosclerosis
has
been
subject
numerous
recent
studies.
In
this
context,
impact
apoptosis
on
was
comprehensively
examined
through
narrative
literature
review.
The
effect
depends
types
involved
stage
disease.
Endothelial
apoptosis,
exacerbated
aging,
may
disrupt
integrity
vascular
lining
thereby
facilitate
infiltration
lipids
into
subendothelial
space
promote
plaque
vulnerability.
Evidence
suggests
smooth
muscle
cells
can
inhibit
their
migration
proliferation
attenuate
formation
early
but
also
induce
instability
thinning
cap
advanced
stages
Macrophage
plays
dual
depending
its
timing
as
it
limit
lesion
cellularity
suppress
progression
initial
while
exacerbating
necrotic
core
development
vulnerability
late
stages.
Although
more
studies
are
required
to
fully
elucidate
atherosclerosis,
therapeutic
manipulation
appears
be
promising
strategy
for
addressing
multifactorial
