Lung cancer immunotherapy: progress, pitfalls, and promises

Molecular Cancer, Journal Year: 2023, Volume and Issue: 22(1)

Published: Feb. 21, 2023

Abstract Lung cancer is the primary cause of mortality in United States and around globe. Therapeutic options for lung treatment include surgery, radiation therapy, chemotherapy, targeted drug therapy. Medical management often associated with development resistance leading to relapse. Immunotherapy profoundly altering approach owing its tolerable safety profile, sustained therapeutic response due immunological memory generation, effectiveness across a broad patient population. Different tumor-specific vaccination strategies are gaining ground cancer. Recent advances adoptive cell therapy (CAR T, TCR, TIL), clinical trials on cancer, hurdles discussed this review. patients (without targetable oncogenic driver alteration) reveal significant responses when treated programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) checkpoint blockade immunotherapies. Accumulating evidence indicates that loss effective anti-tumor immunity tumor evolution. vaccines combined immune inhibitors (ICI) can achieve better effects. To end, present article encompasses detailed overview recent developments immunotherapeutic landscape targeting small (SCLC) non-small (NSCLC). Additionally, review also explores implication nanomedicine immunotherapy as well combinatorial application traditional along regimens. Finally, ongoing trials, obstacles, future outlook strategy highlighted boost further research field.

Language: Английский

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Overview of multiplex immunohistochemistry/immunofluorescence techniques in the era of cancer immunotherapy

Cancer Communications, Journal Year: 2020, Volume and Issue: 40(4), P. 135 - 153

Published: April 1, 2020

Abstract Conventional immunohistochemistry (IHC) is a widely used diagnostic technique in tissue pathology. However, this associated with number of limitations, including high inter‐observer variability and the capacity to label only one marker per section. This review details various highly multiplexed techniques that have emerged circumvent these constraints, allowing simultaneous detection multiple markers on single section comprehensive study cell composition, cellular functional cell‐cell interactions. Among techniques, multiplex Immunohistochemistry/Immunofluorescence (mIHC/IF) has be particularly promising. mIHC/IF provides high‐throughput staining standardized quantitative analysis for reproducible, efficient cost‐effective studies. immediate potential translational research clinical practice, era cancer immunotherapy.

Language: Английский

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Multidimensional analyses reveal distinct immune microenvironment in hepatitis B virus-related hepatocellular carcinoma

Gut, Journal Year: 2018, Volume and Issue: 68(5), P. 916 - 927

Published: July 3, 2018

Background and aims Chronic inflammation induced by chronic hepatitis B virus (HBV) infection increases the risk of hepatocellular carcinoma (HCC). However, little is known about immune landscape HBV-related HCC its influence on design effective cancer immunotherapeutics. Methods We interrogated microenvironments non-viral-related using immunohistochemistry cytometry time-of-flight (CyTOF). On identifying unique subsets enriched in HCC, we further their phenotypes functions next-generation sequencing (NGS) vitro T-cell proliferation assays. Results In-depth interrogation landscapes showed that regulatory T cells (T REG ) CD8 + resident memory RM were whereas Tim-3 CD244 natural killer HCC. NGS isolated from identified distinct functional signatures associated with receptor signalling, costimulation, antigen presentation programmed cell death protein 1 (PD-1) signalling. expressed more PD-1 functionally suppressive exhausted than those non-virus-related Furthermore, immunosuppression could be reversed anti-PD-1 blockade. Using multiplexed tissue immunofluorescence, demonstrated contributed to overall patient survival: a poor prognosis good Conclusion have shown microenvironment immunosuppressive microenvironment. Such in-depth understanding has important implications disease management appropriate application

Language: Английский

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The emerging landscape of spatial profiling technologies

Nature Reviews Genetics, Journal Year: 2022, Volume and Issue: 23(12), P. 741 - 759

Published: July 20, 2022

Language: Английский

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Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging

Nature Methods, Journal Year: 2021, Volume and Issue: 19(3), P. 284 - 295

Published: Nov. 22, 2021

Language: Английский

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Cancer vaccines: Building a bridge over troubled waters

Cell, Journal Year: 2022, Volume and Issue: 185(15), P. 2770 - 2788

Published: July 1, 2022

Language: Английский

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Cancer and Aging: Two Tightly Interconnected Biological Processes

Cancers, Journal Year: 2021, Volume and Issue: 13(6), P. 1400 - 1400

Published: March 19, 2021

Age is one of the main risk factors cancer; several biological changes linked with aging process can explain this. As our population progressively aging, proportion older patients cancer increasing significantly. Due to heterogeneity general health and functional status amongst persons, treatment a major challenge in this vulnerable population. Older often experience more side effects anticancer treatments. Over-treatment should be avoided ensure an optimal quality life. On other hand, under-treatment due fear toxicity frequent problem lead increased relapse worse survival. There delicate balance between benefits therapy toxicity. Robust biomarkers that reflect body’s age may aid outlining individual regimens for cancer. In particular, impact on systemic immunity tumor immune infiltrate considered, given expanding role immunotherapy treatment. review, we summarize current knowledge concerning mechanistic connections cancer, as well could helpful field geriatric oncology.

Language: Английский

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Advancing to the era of cancer immunotherapy

Cancer Communications, Journal Year: 2021, Volume and Issue: 41(9), P. 803 - 829

Published: June 24, 2021

Cancer greatly affects the quality of life humans worldwide and number patients suffering from it is continuously increasing. Over last century, numerous treatments have been developed to improve survival cancer but substantial progress still needs be made before can truly cured. In recent years, antitumor immunity has become most debated topic in research booming development immunotherapy led a new epoch therapy. this review, we describe relationships between tumors immune system, rise immunotherapy. Then, summarize characteristics tumor-associated immunotherapeutic strategies with various molecular mechanisms by showing typical molecules whose antibodies are broadly used clinic those that under investigation. We also discuss important elements individual cells whole human body, including cellular mutations modulation, metabolic reprogramming, microbiome, contexture. addition, present observations technical advancements both diagnostic therapeutic methods aimed at Lastly, controversies challenges negatively impact patient outcomes.

Language: Английский

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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 18, 2023

Abstract Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates progression atherosclerosis, we generate ApoE and GSDME dual deficiency mice. As compared with control mice, −/− /ApoE mice show reduction atherosclerotic lesion area inflammatory response when induced high-fat diet. Human atherosclerosis single-cell transcriptome analysis demonstrates is mainly expressed in macrophages. In vitro, oxidized low-density lipoprotein (ox-LDL) induces expression Mechanistically, ablation macrophages represses ox-LDL-induced inflammation macrophage pyroptosis. Moreover, signal transducer activator transcription 3 (STAT3) directly correlates positively regulates expression. This study explores transcriptional mechanisms during development indicates could be potential therapeutic approach for atherosclerosis.

Language: Английский

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Cancer‐associated fibroblast‐derived exosomal microRNA‐20a suppresses the PTEN/PI3K‐AKT pathway to promote the progression and chemoresistance of non‐small cell lung cancer

Clinical and Translational Medicine, Journal Year: 2022, Volume and Issue: 12(7)

Published: July 1, 2022

Cancer-associated fibroblasts (CAFs) contributes to overall tumor progression. In the current survey, we explored ability of microRNA-20a (miR-20a) within these CAF-derived exosomes influence non-small-cell lung cancer (NSCLC)

Language: Английский

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