Cited by Integrating scRNA-seq and Visium HD for the analysis of the tumor microenvironment in the progression of colorectal cancer

Novel neutrophil targeting platforms in treating Glioblastoma: Latest evidence and therapeutic approaches DOI

Rui Zhong,

Hongmei He,

X Wang

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 150, P. 114173 - 114173

Published: Feb. 11, 2025

Language: Английский

Citations

4-Octyl Itaconate Protects Against Colitis by Modulating Neutrophil Function and Enhancing Intestinal Epithelial Barrier Integrity DOI

Mingyue Guo,

Gechong Ruan,

Runing Zhou

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

Pathological complete response and prognostic predictive factors of neoadjuvant chemoimmunotherapy in early stage triple-negative breast cancer DOI

Xuwei Chen, Hengming Ye,

Daming Xu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 12, 2025

Background Neoadjuvant chemoimmunotherapy (nCIT) has shown promise in treating early-stage triple-negative breast cancer (eTNBC), but predictive biomarkers for pathological response and prognosis remain poorly defined. Objective This study aimed to explore complete prognostic factors eTNBC patients treated with nCIT. Materials methods We retrospectively analyzed 112 who underwent surgery after nCIT at Sun Yat-sen University Cancer Center between June 2019 2023. Pathological was assessed using Miller-Payne grade. Clinicopathological features hematologic markers were univariate multivariate logistic regression or Cox regression, as well Kaplan-Meier survival curves. rate (ORR), (pCR), disease-free (DFS) evaluated. Nomograms predicting pCR DFS constructed based on significant risk the systemic inflammatory index (SIRI). Results Higher baseline lymphocyte counts ( P =0.004) independently associated a higher rate, while elevated monocyte =0.006), neutrophil-to-lymphocyte ratio =0.005), platelet-to-lymphocyte (p = 0.005), SIRI =0.037), immune-inflammation =0.029), preoperative =0.010) lower rate. 0.009) correlated shorter DFS, =0.019) predicted longer DFS. incorporating showed high accuracy Conclusion Hematologic markers, particularly SIRI, are cost-effective reliable predictors of treatment efficacy undergoing nCIT, helping clinicians develop personalized strategies. Clinical trial registration https://www.medicalresearch.org.cn/ , identifier MR-44-24-046099.

Language: Английский

Citations

Integrating scRNA-seq and Visium HD for the analysis of the tumor microenvironment in the progression of colorectal cancer DOI

Chun Wang, Mengying Lu,

Cuimin Chen

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 145, P. 113752 - 113752

Published: Dec. 6, 2024

Language: Английский

Citations