Pseudostellaria heterophylla (Miq.) Pax, a Traditional Folk Medicine, Ameliorates Colorectal Cancer by Remodeling the Tumor Immune Microenvironment

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: 342, P. 119362 - 119362

Published: Jan. 17, 2025

Language: Английский

---

Targeting the epigenetic regulation of ferroptosis: a potential therapeutic approach for sepsis-associated acute kidney injury

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 6, 2025

Abstract Sepsis is a syndrome of organ dysfunction caused by the invasion pathogenic microorganisms. In clinical practice, patients with sepsis are prone to concurrent acute kidney injury, which has high morbidity and mortality rates. Thus, understanding pathogenesis sepsis-associated injury significant importance. Ferroptosis an iron-dependent programmed cell death pathway, proved play critical role in process through various mechanisms. Epigenetic regulation modulates content function nucleic acids proteins within cells modifications. Its impact on ferroptosis garnered increasing attention; however, epigenetic targeting not been fully elucidated. Growing evidence suggests that can modulate complex pathway networks, thereby affecting development prognosis injury. This paper summarizes regulatory mechanisms ferroptosis, providing new insights for targeted therapy

Language: Английский

---

Metabolic reprogramming, autophagy, and ferroptosis: Novel arsenals to overcome immunotherapy resistance in gastrointestinal cancer

Cancer Medicine, Journal Year: 2023, Volume and Issue: 12(21), P. 20573 - 20589

Published: Oct. 20, 2023

Abstract Background Gastrointestinal cancer poses a serious health threat owing to its high morbidity and mortality. Although immune checkpoint blockade (ICB) therapies have achieved meaningful success in most solid tumors, the improvement survival gastrointestinal cancers is modest, sparse response widespread resistance. Metabolic reprogramming, autophagy, ferroptosis are key regulators of tumor progression. Methods A literature review was conducted investigate role metabolic immunotherapy resistance cancer. Results play pivotal roles regulating survival, differentiation, function cells within microenvironment. These processes redefine nutrient allocation blueprint between cells, facilitating evasion, which critically impacts therapeutic efficacy for cancers. Additionally, there exists profound crosstalk among ferroptosis. interactions paramount anti‐tumor immunity, further promoting formation an immunosuppressive microenvironment immunotherapy. Conclusions Consequently, it imperative conduct comprehensive research on This understanding will illuminate clinical potential targeting these pathways their regulatory mechanisms overcome

Language: Английский

---

Biologic activity and treatment resistance to gastrointestinal cancer: the role of circular RNA in autophagy regulation

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Aug. 30, 2024

Circular RNAs (circRNAs) lack the 5'-end methylated guanine cap structure and 3' polyadenylate tail structure, classifying it as a non-coding RNA. With extensive investigation of circRNA, its role in regulating cell death has garnered significant attention recent years, establishing recognized participant cancer's biological processes. Autophagy, an essential pathway programmed (PCD), involves formation autophagosomes using lysosomes to degrade cellular contents under regulation various autophagy-related (ATG) genes. Numerous studies have demonstrated that circRNA can modulate activity cancer cells by influencing autophagy pathway, exhibiting dualistic suppressing or promoting carcinogenesis. In this review, we comprehensively analyze how impacts progression gastrointestinal (GIC). Additionally, discuss drug resistance phenomena associated with GIC. This review offers valuable insights into exploring potential targets for prognosis treatment strategies related

Language: Английский

---