Targeting tumor angiogenesis and metabolism with photodynamic nanomedicine DOI Creative Commons

Yong Lv,

Lihui Pu,

Bei Ran

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: April 1, 2025

Photodynamic therapy (PDT) holds considerable promise as a tumor treatment modality, characterized by its targeted action, compatibility with other therapeutic approaches, and non - invasive features. PDT can achieve remarkable spatiotemporal precision in ablation through the generation of reactive oxygen species (ROS). Nevertheless, despite potential treatment, encounters multiple challenges practical applications. is highly dependent, thus effectiveness be markedly influenced hypoxia. The co-existence abnormal vasculature metabolic deregulation gives rise to hypoxic microenvironment, which not only sustains survival but also undermines efficacy PDT. Consequently, targeting angiogenesis metabolism essential for revitalizing This review emphasizes mechanisms strategies predominantly concentrating on interfering reprogramming cell metabolism. Lastly, outlining future perspectives current limitations are summarized. could provide new insights methodologies overcoming associated ultimately advancing field

Language: Английский

RGD peptide in cancer targeting: Benefits, challenges, solutions, and possible integrin–RGD interactions DOI Creative Commons
Hossein Javid, Mahsa Akbari Oryani,

Nastaran Rezagholinejad

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(2)

Published: Jan. 1, 2024

RGD peptide can be found in cell adhesion and signaling proteins, such as fibronectin, vitronectin, fibrinogen. peptides' principal function is to facilitate by interacting with integrin receptors on the surface. They have been intensively researched for use biotechnology medicine, including incorporation into biomaterials, conjugation medicinal molecules or nanoparticles, labeling imaging agents. peptides utilized specifically target cancer cells tumor vasculature engaging these integrins, improving drug delivery efficiency minimizing adverse effects healthy tissues. RGD-functionalized carriers are a viable option therapy this focused approach has demonstrated promise future. Writing review significantly influence how drugs developed future our understanding of peptide, finding knowledge gaps, fostering innovation, making design easier.

Language: Английский

Citations

61
Advance in peptide-based drug development: delivery platforms, therapeutics and vaccines DOI Creative Commons
Wen‐Jing Xiao, Wenjie Jiang, Zheng Chen

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 5, 2025

The successful approval of peptide-based drugs can be attributed to a collaborative effort across multiple disciplines. integration novel drug design and synthesis techniques, display library technology, delivery systems, bioengineering advancements, artificial intelligence have significantly expedited the development groundbreaking drugs, effectively addressing obstacles associated with their character, such as rapid clearance degradation, necessitating subcutaneous injection leading increasing patient discomfort, ultimately advancing translational research efforts. Peptides are presently employed in management diagnosis diverse array medical conditions, diabetes mellitus, weight loss, oncology, rare diseases, additionally garnering interest facilitating targeted platforms advancement vaccines. This paper provides an overview present market clinical trial progress therapeutics, platforms, It examines key areas through literature analysis emphasizes structural modification principles well recent advancements screening, design, technologies. accelerated including peptide-drug complexes, new vaccines, innovative diagnostic reagents, has potential promote era precise customization disease therapeutic schedule.

Language: Английский

Citations

5
Targeted therapy and immunotherapy for gastric cancer: rational strategies, novel advancements, challenges, and future perspectives DOI Creative Commons
Dong Luo, Yunmei Liu, Zhengmao Lu

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: Feb. 8, 2025

Abstract Gastric cancer (GC) is one of the most common malignant tumors worldwide, and its treatment has been a focus medical research. Herein we systematically review current status advancements in targeted therapy immunotherapy for GC, which have emerged as important strategies recent years with great potential, summarize efficacy safety such treatments. Targeted therapies against key targets including epidermal growth factor receptor (EGFR), human 2 (HER2), vascular endothelial (VEGF)/VEGF (VEGFR), shown remarkable therapeutic efficacies by inhibiting tumor progression and/or blood supply. In particular, markable breakthroughs made HER2-targeting drugs HER2-positive GC patients. To address intrinsic acquired resistances to drugs, novel agents bispecific antibodies antibody–drug conjugates (ADC) targeting HER2 developed. Immunotherapy enhances recognition elimination cells activating body anticancer immune system. Programmed cell death protein 1 (PD-1) programmed death-ligand (PD-L1) are commonly used immunotherapeutic some success treatment. Innovative modalities, adoptive therapy, vaccines, non-specific immunomodulators oncolytic viruses promise early-stage clinical trials GC. Clinical supported that can significantly improve survival quality life However, effects need be further improved more personalized, advancement researches on microenvironment. Further studies remain needed issues drug resistance adverse events pertaining The combined application individualized should explored developed, provide effective treatments

Language: Английский

Citations

2
Green Synthesis of Zinc Oxide Nanoparticles: Preparation, Characterization, and Biomedical Applications - A Review DOI Creative Commons
Mohamed T. El‐Saadony, Guihong Fang, Si Yan

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12889 - 12937

Published: Dec. 1, 2024

Abstract: Over the last decade, biomedical nanomaterials have garnered significant attention due to their remarkable biological properties and diverse applications in biomedicine. Metal oxide nanoparticles (NPs) are particularly notable for wide range of medicinal uses, including antibacterial, anticancer, biosensing, cell imaging, drug/gene delivery. Among these, zinc (ZnO) NPs stand out versatility effectiveness. Recently, ZnO become a primary material various sectors, such as pharmaceutical, cosmetic, antimicrobials, construction, textile, automotive industries. can generate reactive oxygen species induce cellular apoptosis, thus underpinning potent anticancer antibacterial properties. To meet growing demand, numerous synthetic approaches been developed produce NPs. However, traditional manufacturing processes often involve economic environmental costs, prompting search more sustainable alternatives. Intriguingly, synthesis methods utilizing plants, plant extracts, or microorganisms emerged ideal producing These green production techniques offer medicinal, economic, environmental, health benefits. This review highlights latest advancements applications, showcasing potential revolutionize field with eco-friendly cost-effective solutions. Keywords: antimicrobial, antioxidant, synthesis, nanomedicine, nanoparticle,

Language: Английский

Citations

9
The Use of Plant Viral Nanoparticles in Cancer Biotherapy—A Review DOI Creative Commons
Mamorake Donty Komane, Prudence Ngalula Kayoka‐Kabongo, Daria A. Rutkowska

et al.

Viruses, Journal Year: 2025, Volume and Issue: 17(2), P. 218 - 218

Published: Feb. 1, 2025

Cancer is a major global health problem that poses significant challenges. Conventional cancer therapies often have severe side effects, necessitating the development of novel therapeutic approaches are more effective and less toxic. The utilization plant viral nanoparticles one promising strategies for biotherapy. Plant exhibit advantageous properties, including safety, high stability, rapid production scalability, biocompatibility biodegradability, structural uniformity, inherent immunogenicity, ease modification update efficacy as well lower cost implications, making them attractive vehicles applications. Various studies demonstrated in targeted drug/molecule delivery, tumor imaging immunotherapy, highlighting their potential versatile platform drawbacks include perceived ability to induce hypersensitive/allergic immune response, non-well-defined regulatory approval processes reluctance pharmaceutical companies adapt manufacturing facilitate plant-based expression. This review discusses applications virus-derived therapeutics prospects translating these findings into clinical practice.

Language: Английский

Citations

1
Bacterial Systems as a Precision Delivery Platform of Therapeutic Peptides for Cancer Therapy DOI Creative Commons
Jinyuan Liu, Guizhi Shen, Xuehai Yan

et al.

Polymer science & technology., Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

1
Improving Tumor Targeting and Penetration for Nanoparticle‐Mediated Cancer Therapy DOI Creative Commons
Zhangyi Luo, Chien‐Yu Chen, Song Li

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Recent advances in the development of tumor-targeting nanoparticles (NPs) significantly enhance cancer therapies by effectively increasing therapeutic window drugs, improving response tumor cells, and augmenting anti-tumor immunity. However, understanding process remains elusive because complex vivo behavior nanoparticles. Various factors are reported to alter this process; however, systematic studies on mechanisms remain limited. In review, an overview current strategies for targeting their applications chemotherapy immunotherapy, with a focus advancement various barriers effective penetration is provided.

Language: Английский

Citations

1
Harnessing Peptide-based Nanotherapeutics: Pioneering Melanoma Management from Diagnosis to Theranostics DOI
Shalini Shukla,

Pooja Khairnar,

Aachal Hedaoo

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106811 - 106811

Published: March 1, 2025

Language: Английский

Citations

1
Advances in nanotechnology for targeting cancer-associated fibroblasts: A review of multi-strategy drug delivery and preclinical insights DOI Creative Commons

Zhongsong Zhang,

Yujie Tang,

Dan Luo

et al.

APL Bioengineering, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 1, 2025

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment by promoting growth, immune evasion, and metastasis. Recently, drug delivery systems targeting CAFs have emerged as promising long-term effective approach to cancer treatment. Advances nanotechnology, particular, led development of nanomedicine designed specifically target CAFs, offering new possibilities for precise personalized therapies. This article reviews recent progress using nanocarriers that CAFs. Additionally, we explore potential combining multiple therapies, such chemotherapy immunotherapy, with enhance efficacy overcome resistance. Although many preclinical studies show promise, clinical application still faces considerable challenges, especially terms penetration large-scale production. Therefore, this review aims provide fresh perspective on CAF-targeted highlight future research directions applications.

Language: Английский

Citations

1
Dual‐Engineered Macrophage‐Microbe Encapsulation for Metastasis Immunotherapy DOI
Leyang Wu,

Liyuan Qiao,

Shu‐Hui Zhang

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 18, 2024

Abstract Lung metastases are the leading cause of death among cancer patients. The challenges inefficient drug delivery, compounded by a robust immunosuppressive microenvironment, make effective treatment difficult. Here, an innovative dual‐engineered macrophage‐microbe encapsulation (Du‐EMME) therapy is developed that integrates modified macrophages and engineered antitumor bacteria. These macrophages, termed R‐GEM cells, designed to express RGD peptides on extracellular membranes, enhancing their tumor cell binding intratumor enrichment. cells cocultured with attenuated Salmonella typhimurium VNP20009, producing (R‐GEM/VNP cells). intracellular bacteria maintain bioactivity for more than 24 h, released from R‐GEM/VNP within continue exert bacteria‐mediated effects. This further supported macrophage‐based chemotaxis camouflage, which enhance intratumoral enrichment biocompatibility Additionally, loaded IFNγ‐secreting strains (VNP‐IFNγ) form R‐GEM/VNP‐IFNγ cells. Treatment these effectively halts lung metastatic progression in three mouse models (breast cancer, melanoma, colorectal cancer). vigorously activate suppressing tumor‐promoting M2‐type MDSCs, Tregs, tumor‐antagonizing M1‐type mature DCs, Teffs. Du‐EMME offers promising strategy targeted enhanced immunity treating metastases.

Language: Английский

Citations

7