Investigating modifiable risk factors associated with ideal cardiovascular health among cancer survivors: a scoping review
Cardio-Oncology,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 31, 2025
Abstract
Background
Cancer
survivors
are
at
higher
risk
of
developing
cardiovascular
diseases
and
face
worse
morbidity
mortality
outcomes
than
the
general
population.
The
American
Heart
Association
(AHA)
introduced
Life’s
Essential
8
framework,
encompassing
eight
modifiable
factors
lifestyle
behaviors
for
maintaining
ideal
health
(CVH).
Although
this
framework
is
well-established
predicting
CVH
in
population,
studies
on
its
association
with
among
cancer
remain
scattered
across
literature.
Objective
This
review
maps
existing
literature
surrounding
factors,
behaviors,
CVH,
to
take
stock
what
known,
identify
methodological
strengths
weaknesses,
propose
promising
research
directions.
Methods
A
scoping
was
conducted
examining
different
dimensions
adult
survivors.
Measurement
methods
metrics,
determinants
associated
were
examined.
Results
Twenty-two
articles
met
eligibility
criteria.
Of
which,
82%
(
n
=
18)
published
or
after
2020.
Fourteen
(about
64%)
followed
AHA’s
conceptualize
CVH.
Higher
scores
linked
better
associations
noted
social
inequalities
neighborhood
environmental
underscoring
complexity
Conclusions
Research
appears
have
accelerated
recent
years,
yet
many
gaps
orient
clinical
public
practice.
Promising
directions
include
expanding
investigations
into
pre-diagnosis
addressing
disparities
diverse
populations,
conducting
longitudinal
clarify
causal
pathways
between
treatments,
outcomes.
Language: Английский
Cardiovascular mortality in people with cancer compared to the general population: A systematic review and meta‐analysis
Cancer Medicine,
Journal Year:
2024,
Volume and Issue:
13(15)
Published: Aug. 1, 2024
Abstract
Background
Cardiovascular
disease
(CVD)
is
the
leading
cause
of
non‐cancer
death
in
cancer
survivors,
but
risk
CVD
varies
between
cancers.
Objectives
To
synthesise
available
evidence
on
patterns
and
magnitude
mortality
risk.
Methods
A
systematic
search
Medline
(OVID),
CINAHL
Scopus
databases
from
01‐January‐2000
to
16‐July‐2023
studies
people
with
cancer,
reporting
population
compared
a
reference
(e.g.
general
population)
as
standardised
ratios
(SMR).
Meta‐analysis
SMRs
across
types
were
pooled
using
random‐effects
model
allow
for
heterogeneity
true
effect
size
studies.
Results
We
identified
136
16
countries.
Sample
sizes
ranged
157
7,529,481.
The
majority
(
n
=
98;
72%)
conducted
United
States,
followed
by
Europe
22;
16%).
most
common
cancers
studied
gastrointestinal
34
studies),
haematological
31)
breast
29).
total
876
extracted
diverse
conditions.
Of
those,
(535;
61%)
indicated
an
increased
(SMR
>1),
109
(12%)
lower
<1)
232
(27%)
equivalent
(95%
CI
SMR
included
1)
population.
meta‐analysis
all
reported
showed
1.55,
95%
1.40–1.72)
survivors
varied
conditions
1.36
1.29–1.44)
heart
diseases
1.56
1.39–1.76)
cerebrovascular
diseases.
types,
ranging
1.14
1.04–1.25)
testicular/germ
cell
tumours
2.82
2.20–3.63)
brain/central
nervous
system
tumours.
Conclusions
Cancer
are
at
premature
population,
type
CVD.
Future
research
should
focus
understanding
mechanisms
behind
develop
appropriate
interventions.
Language: Английский