Chimeric Antigen Receptor-T Cells in the Modern Era of Chronic Lymphocytic Leukemia Treatment DOI Open Access
Alycia Hatashima,

Mazyar Shadman,

Vikram Raghunathan

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 268 - 268

Published: Jan. 15, 2025

Pathway inhibitors targeting Bruton tyrosine kinase (BTK) and B-cell lymphoma-2 (BCL-2) have dramatically changed the treatment landscape for both treatment-naïve relapsed/refractory chronic lymphocytic leukemia (CLL). However, with increased utilization, a growing number of patients will experience progressive disease on agents. This subgroup “double refractory” has limited options poor prognosis. Chimeric antigen receptor (CAR)-T cells transformed malignancies. Although earliest success CAR-T cell therapy was in CLL, clinical application this modality lagged until recent approval first product CLL. In review, we describe current upfront subsequent therapies unmet need novel agents highlighted by burgeoning role challenges therapy.

Language: Английский

Chimeric Antigen Receptor-T Cells in the Modern Era of Chronic Lymphocytic Leukemia Treatment DOI Open Access
Alycia Hatashima,

Mazyar Shadman,

Vikram Raghunathan

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(2), P. 268 - 268

Published: Jan. 15, 2025

Pathway inhibitors targeting Bruton tyrosine kinase (BTK) and B-cell lymphoma-2 (BCL-2) have dramatically changed the treatment landscape for both treatment-naïve relapsed/refractory chronic lymphocytic leukemia (CLL). However, with increased utilization, a growing number of patients will experience progressive disease on agents. This subgroup “double refractory” has limited options poor prognosis. Chimeric antigen receptor (CAR)-T cells transformed malignancies. Although earliest success CAR-T cell therapy was in CLL, clinical application this modality lagged until recent approval first product CLL. In review, we describe current upfront subsequent therapies unmet need novel agents highlighted by burgeoning role challenges therapy.

Language: Английский

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