Circadian antidepressant treatments in depression: A systematic review and meta-analysis DOI

Chuying Li,

Pengpeng Cao, Yuhao Li

et al.

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 31, 2025

The purpose of the present study was to explore whether maximum efficacy treatments would be dependent on time day at which antidepressants were taken. Databases searched for randomized experiments or controlled trials involving interventions any taken a particular day. Out 10 348 screened articles, studies included in meta-analyses. optimal efficacies 5 out 15 drugs zeitgeber (ZT) 2, including fluoxetine, sertraline, citalopram, doxepin, and agomelatine. best therapeutic effects mirtazapine, trazodone, agomelatine ZT10, while venlafaxine fluvoxamine ZT6 ZT13, respectively. melatonin administration period treatment dependence. We found with different mechanisms might have same times. These findings may guide evidence-based antidepressant choices dosing time. More prospective are demanded establish recommendations circadian timing depression based It interest further evaluate this time-selection as potential viable novel future research.

Language: Английский

Circadian antidepressant treatments in depression: A systematic review and meta-analysis DOI

Chuying Li,

Pengpeng Cao, Yuhao Li

et al.

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: March 31, 2025

The purpose of the present study was to explore whether maximum efficacy treatments would be dependent on time day at which antidepressants were taken. Databases searched for randomized experiments or controlled trials involving interventions any taken a particular day. Out 10 348 screened articles, studies included in meta-analyses. optimal efficacies 5 out 15 drugs zeitgeber (ZT) 2, including fluoxetine, sertraline, citalopram, doxepin, and agomelatine. best therapeutic effects mirtazapine, trazodone, agomelatine ZT10, while venlafaxine fluvoxamine ZT6 ZT13, respectively. melatonin administration period treatment dependence. We found with different mechanisms might have same times. These findings may guide evidence-based antidepressant choices dosing time. More prospective are demanded establish recommendations circadian timing depression based It interest further evaluate this time-selection as potential viable novel future research.

Language: Английский

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