E2F transcription factors promote tumorigenicity in pancreatic ductal adenocarcinoma DOI Creative Commons
Ludivine Bertonnier‐Brouty, Jonas Andersson, Tuomas Kaprio

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(9)

Published: April 30, 2024

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with limited treatment options, illustrating an urgent need to identify new drugable targets in PDACs. Objective Using similarities between tumor development and normal embryonic development, which accompanied by rapid cell expansion, we aimed characterize signaling pathways that were reinitiated during formation expansion. Methods Results Here, report transcription factors E2F1 E2F8 are potential key regulators PDAC. RNA expression mainly localized proliferating cells developing pancreas malignant Silencing PANC‐1 pancreatic inhibited proliferation impaired spreading migration. Moreover, loss also affected viability apoptosis E2F PDAC tissues correlating mitosis pathway genes, suggesting promote cycle regulation tumorigenesis cells. Conclusion Our findings illustrate expressed progenitor cells, where they contribute expansion proliferation, viability, migration making these genes attractive therapeutic prognostic markers for cancer.

Language: Английский

MicroRNA profiling in pancreatic cancer and chronic pancreatitis: Novel insights and pathway analysis DOI
Hossein Azadinejad, Mohammad Farhadi Rad, Ali Babaeizad

et al.

Human Gene, Journal Year: 2025, Volume and Issue: unknown, P. 201410 - 201410

Published: April 1, 2025

Language: Английский

Citations

0
E2F transcription factors promote tumorigenicity in pancreatic ductal adenocarcinoma DOI Creative Commons
Ludivine Bertonnier‐Brouty, Jonas Andersson, Tuomas Kaprio

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(9)

Published: April 30, 2024

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with limited treatment options, illustrating an urgent need to identify new drugable targets in PDACs. Objective Using similarities between tumor development and normal embryonic development, which accompanied by rapid cell expansion, we aimed characterize signaling pathways that were reinitiated during formation expansion. Methods Results Here, report transcription factors E2F1 E2F8 are potential key regulators PDAC. RNA expression mainly localized proliferating cells developing pancreas malignant Silencing PANC‐1 pancreatic inhibited proliferation impaired spreading migration. Moreover, loss also affected viability apoptosis E2F PDAC tissues correlating mitosis pathway genes, suggesting promote cycle regulation tumorigenesis cells. Conclusion Our findings illustrate expressed progenitor cells, where they contribute expansion proliferation, viability, migration making these genes attractive therapeutic prognostic markers for cancer.

Language: Английский

Citations

2