Omicron neutralization character in patients with breast cancer and liver cancer after the nationwide omicron outbreak DOI
Shaohua Zhang, Lili Tang,

Chunmei Bao

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(11)

Published: June 1, 2024

Abstract Background The surge in omicron variants has caused nationwide breakthrough infections mainland China since the December 2022. In this study, we report neutralization profiles of serum samples from patients with breast cancer and liver who had contracted subvariant infections. Methods real‐world enrolled 143 COVID‐19‐vaccinated (81 62 cancers) 105 unvaccinated (58 47 after infection. Anti‐spike receptor binding domain (RBD) IgGs 50% pseudovirus titer (pVNT 50 ) for preceding (wild type), circulating (BA.4‐BA.5, BF.7), new subvariants (XBB.1.5) were comprehensively analyzed. Results Patients receiving booster doses higher levels anti‐spike RBD IgG against BF.7) a novel compared to Additionally, all vaccinated produced neutralizing antibody titers patients. However, XBB.1.5 than Omicron infection, trend being more pronounced Moreover, found that there was no correlation between wildtype virus titer, but positive Conclusion Our study may be differences vaccine response protective effect COVID‐19 infection cancer. Therefore, recommend strategies should optimized based on components immunology different

Language: Английский

Omicron neutralization character in patients with breast cancer and liver cancer after the nationwide omicron outbreak DOI
Shaohua Zhang, Lili Tang,

Chunmei Bao

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(11)

Published: June 1, 2024

Abstract Background The surge in omicron variants has caused nationwide breakthrough infections mainland China since the December 2022. In this study, we report neutralization profiles of serum samples from patients with breast cancer and liver who had contracted subvariant infections. Methods real‐world enrolled 143 COVID‐19‐vaccinated (81 62 cancers) 105 unvaccinated (58 47 after infection. Anti‐spike receptor binding domain (RBD) IgGs 50% pseudovirus titer (pVNT 50 ) for preceding (wild type), circulating (BA.4‐BA.5, BF.7), new subvariants (XBB.1.5) were comprehensively analyzed. Results Patients receiving booster doses higher levels anti‐spike RBD IgG against BF.7) a novel compared to Additionally, all vaccinated produced neutralizing antibody titers patients. However, XBB.1.5 than Omicron infection, trend being more pronounced Moreover, found that there was no correlation between wildtype virus titer, but positive Conclusion Our study may be differences vaccine response protective effect COVID‐19 infection cancer. Therefore, recommend strategies should optimized based on components immunology different

Language: Английский

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