Effect of Different Glucose Levels and Glycation on Meningioma Cell Migration and Invasion DOI Open Access
Philipp Selke,

Christian Strauß,

Rüdiger Horstkorte

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10075 - 10075

Published: Sept. 19, 2024

Meningiomas are predominantly benign tumors, but there also malignant forms that associated with a poor prognosis. Like almost all meningiomas metabolize glucose as part of aerobic glycolysis (Warburg effect) for energy supply, so attempts to influence the prognosis tumor diseases using glucose-reduced diet. This altered metabolism leads called hallmarks cancer, such glycation and glycosylation. In this study, we investigated low (3 mM), normal (5.5 mM) high (15 on meningioma cell line (IOMM-Lee, WHO grade 3). addition, methylglyoxal, by-product precursor glycation, was investigated. Impedance-based methods (ECIS RTCA) were used study migration invasion, immunoblotting analyze expression proteins relevant these processes, focal adhesion kinase (FAK), merlin or integrin ß1. We able show reduced invasive potential cells, which amount sialic acid. Under glucose, barrier function impaired decreased, correlated decreased FAK.

Language: Английский

High glucose inhibits autophagy and promotes the proliferation and metastasis of colorectal cancer through the PI3K/AKT/mTOR pathway DOI Creative Commons
Feng Li,

Xing Wan,

Zhigui Li

et al.

Cancer Medicine, Journal Year: 2024, Volume and Issue: 13(11)

Published: June 1, 2024

Colorectal cancer (CRC) ranks among the most prevalent malignancies worldwide, characterized by its complex etiology and slow research progress. Diabetes, as an independent risk factor for CRC, has been widely certified. Consequently, this study centers on elucidating intricacies of CRC cells initiation progression within a high-glucose environment.

Language: Английский

Citations

4
Colorectal Cancer: Pathogenesis and Targeted Therapy DOI Creative Commons
Jingyuan Li,

Jiashu Pan,

Lisheng Wang

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(3)

Published: March 1, 2025

Colorectal cancer (CRC) ranks among the most prevalent malignant neoplasms globally. A growing body of evidence underscores pivotal roles genetic alterations and dysregulated epigenetic modifications in pathogenesis CRC. In recent years, reprogramming tumor cell metabolism has been increasingly acknowledged as a hallmark cancer. Substantial suggests crosstalk between metabolic modifications, highlighting complex interplay genome that warrants further investigation. Biomarkers associated with characteristics CRC hold significant clinical implications. Nevertheless, elucidating genetic, epigenetic, landscapes continues to pose considerable challenges. Here, we attempt summarize key genes driving onset progression related regulators, clarify gene expression signaling pathways regulation, explore potential events reprogramming, providing comprehensive mechanistic explanation for Finally, by integrating reliable targets from genetics, epigenetics, processes promise translation into practice, aim offer more strategies overcome bottlenecks treatment.

Language: Английский

Citations

0
CLMP increases 5-fluorouracil sensitivity in colorectal cancer through the inhibition of autophagy DOI
Kun Yu, Hongjiang Pu, Xuan Zhang

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102771 - 102771

Published: Jan. 1, 2025

Language: Английский

Citations

0
Effect of Different Glucose Levels and Glycation on Meningioma Cell Migration and Invasion DOI Open Access
Philipp Selke,

Christian Strauß,

Rüdiger Horstkorte

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10075 - 10075

Published: Sept. 19, 2024

Meningiomas are predominantly benign tumors, but there also malignant forms that associated with a poor prognosis. Like almost all meningiomas metabolize glucose as part of aerobic glycolysis (Warburg effect) for energy supply, so attempts to influence the prognosis tumor diseases using glucose-reduced diet. This altered metabolism leads called hallmarks cancer, such glycation and glycosylation. In this study, we investigated low (3 mM), normal (5.5 mM) high (15 on meningioma cell line (IOMM-Lee, WHO grade 3). addition, methylglyoxal, by-product precursor glycation, was investigated. Impedance-based methods (ECIS RTCA) were used study migration invasion, immunoblotting analyze expression proteins relevant these processes, focal adhesion kinase (FAK), merlin or integrin ß1. We able show reduced invasive potential cells, which amount sialic acid. Under glucose, barrier function impaired decreased, correlated decreased FAK.

Language: Английский

Citations

0