Synthesis, antifungal activity, and 3D-QSAR study of novel L-carvone-based thiazole-hydrazone derivatives DOI
Baoyu Li,

Rongzhu Wen,

Wengui Duan

et al.

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 65, P. 58 - 63

Published: Dec. 5, 2024

Language: Английский

An Effective and Promising Strategy for Plant Protection: Synthesis of L-Carvone-Based Thiazolinone–Hydrazone/Nanochitosan Complexes with Antifungal Activity and Sustained Releasing Performance DOI Open Access
Baoyu Li,

Wengui Duan,

Guishan Lin

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4595 - 4595

Published: April 23, 2024

The development of novel natural product-derived nano-pesticide systems with loading capacity and sustained releasing performance bioactive compounds is considered an effective promising plant protection strategy. In this work, 25

Language: Английский

Citations

5
Synthesis of L-carvone-derived imidazo[1,2-a]pyrimidine / nano sodium alginate complexes with significant antifungal activity and sustained releasing performance DOI
Zhaolei Zhang, Baoyu Li,

Wengui Duan

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141823 - 141823

Published: Feb. 1, 2025

Language: Английский

Citations

0
Design, Synthesis, Antifungal Evaluation, and Action Mechanism of Novel l-Carvone-Based Derivatives as Potential Succinate Dehydrogenase Inhibitors DOI
Hongyi Chen,

Zunyun Jiang,

Ziyun Mai

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Natural products serve as a crucial source of compounds for developing novel agricultural antifungals. In this work, we utilized the natural product l-carvone molecular scaffold to design and synthesize three series l-carvone-based derivatives. The in vitro bioassay results indicated that most target exhibited remarkable antifungal activity. Notably, compound C3 demonstrated broad-spectrum activity against Rhizoctonia solani, Botrytis cinerea, Sclerotinia sclerotiorum, Gibberella zeae, Valsa mali, with EC50 values 0.274, 0.985, 4.17, 5.71, 2.29 μg/mL, respectively. vivo preventative efficacies C11 R. solani C13 B. cinerea revealed they had potential mechanism study, cell membrane permeability experiment showed significantly increased membrane, microscopic observations could destroy structural integrity cells reduce number mitochondria, thus affecting normal growth mycelia. Furthermore, mitochondrial detection, succinate dehydrogenase (SDH) enzyme assay, dynamics (MD) simulations, docking experiments further action binding mode SDH may be similar those thifluzamide. abovementioned provided valuable reference discovery inhibitor fungicides.

Language: Английский

Citations

0
Synthesis, antifungal activity, and 3d-QSAR study of L- carvone-based pyrazole-oxime ester compounds DOI
Xinyan Liu, Wengui Duan,

Guishan Lin

et al.

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 10

Published: Sept. 16, 2024

Natural products can provide versatile substructures with potential bioactivity and biocompatibility for exploring bioactive compounds. Herein, to explore novel natural product-derived antifungal agents, 21 unreported

Language: Английский

Citations

2
Benzohydrazide as a good precursor for the synthesis of novel bioactive and anti-oxidant 2-phenyl-1,3,4-oxadiazol-aminoacid derivatives: Structural determination, biological and anti-oxidant activity DOI Creative Commons

Khaled Briki,

Talal Lahreche,

Mouna Souad Abbassi

et al.

Arabian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 17(6), P. 105767 - 105767

Published: March 30, 2024

The synthesis and biological assessment of 2,5-disubstituted-1,3,4-oxadiazole derivatives from benzo hydrazide amino acids as novel potential antioxidant antibacterial agents have been reported. structures the new compounds were characterized by physicochemical properties spectral methods. synthesized screened for their in vitro activity against three Gram-positive bacterial strains, namely Staphylococcus aureus ATCC 25923, Bacillus cereus 14579, Listeria innocua 33090, two Gram-negative Pseudomonas aeruginosa 27853, Escherichia coli 25922, antifungal Candida albicans 10231 comparison with Amoxicillin, Tetracycline, Gentamicin Oxacillin standards. Most excellent efficacy, some them, such 5i, 5g, 5d, 5c, 5j can inhibit better or very close to that Gentamicin, used Compounds 5b 5i provided good results L. inhibition values IZ = 14 mm 22 mm, respectively, while rest antibiotics unable it. 5g showed C. between 31 34 mm. These than all standards used. MIC value (25 µg/ml) 5(c-e), 5(i-j) B. represent best tested compounds. All target also radical scavenging activities DPPH, FRAP, TAC assays found be agents. According results, it was observed most a concentration 250 µg/ml an agent (76 % < RSA 95.5 %) which gave percentage ascorbic acid BHT.

Language: Английский

Citations

1
Synthesis and Antifungal Activity Evaluation of Novel L-Carvone-Based 1,3,4-Thiadiazole-amide Derivatives as a Potential Succinate Dehydrogenase Inhibitor DOI
Baoyu Li, Wengui Duan,

Guishan Lin

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(47), P. 26116 - 26124

Published: Nov. 14, 2024

In an effort to explore new-type high-efficiency antifungal agents, 25 novel

Language: Английский

Citations

1
Synthesis, antifungal activity, and 3D-QSAR study of novel L-carvone-based thiazole-hydrazone derivatives DOI
Baoyu Li,

Rongzhu Wen,

Wengui Duan

et al.

Phytochemistry Letters, Journal Year: 2024, Volume and Issue: 65, P. 58 - 63

Published: Dec. 5, 2024

Language: Английский

Citations

1