Development and In Vitro characterization of Azadirachta Indica Gum grafted polyacrylamide Based pH‐Sensitive Hydrogels to improve the Bioavailability of Lansoprazole DOI Open Access
Muhammad Abid Mustafa, Hafiz Rashid Hussain, Jawad Akbar Khan

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract The present study intended to develop a pH‐responsive hydrogel based on Neem gum (Ng) improve Lansoprazole (LSP) oral bioavailability. Azadirachta Indica seed extract was used obtain Ng. formulations (F1–F9) were prepared using different Ng ratios, Acrylamide (AAm), and methylene‐bis‐acrylamide (MBA). formulated hydrogels characterized through FTIR, thermal analysis, swelling ratio, SEM, sol‐gel In‐Vitro drug release, cytotoxicity analysis. extracted produce powder containing 21.5 % Prepared showed maximum at pH 7.4, whereas the an acidic insignificant. LSP‐loaded demonstrated regulated release of LSP for up 24 h indicated Super Case II transport mechanism. During cytotoxic evaluation, delivery system minimal towards normal cells, while percent carried out longer duration (up 96 h). revealed indica gum‐based as promising technique precisely delivering LSP.

Language: Английский

Nanogels in Biomedical Engineering: Revolutionizing Drug Delivery, Tissue Engineering, and Bioimaging DOI

Atieh Janmaleki Dehchani,

Aliakbar Jafari,

Farangis Shahi

et al.

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(10)

Published: Oct. 1, 2024

ABSTRACT Nanogels represent a significant innovation in the fields of nanotechnology and biomedical engineering, combining properties hydrogels nanoparticles to create versatile platforms for drug delivery, tissue bioimaging, other applications. These nanoscale hydrogels, typically ranging from 10 1000 nm, possess unique characteristics such as high water content, biocompatibility, ability encapsulate both hydrophilic hydrophobic molecules. The review explores synthesis, structural configurations, stimuli‐responsive nature nanogels, highlighting their adaptability targeted including across challenging barriers like blood–brain barrier. Furthermore, paper delves into applications particularly delivery systems, demonstrating potential revolutionize these fields. Despite promising preclinical results, challenges remain translating technologies clinical practice, issues related stability, scalability, regulatory approval. concludes by discussing future perspectives, emphasizing need further research optimize ultimately aiming enhance efficacy safety settings.

Language: Английский

Citations

11
Intelligent responsive nanogels: New Horizons in cancer therapy DOI
Mazlina Musa, Xinxin Sun, Jianbin Shi

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 669, P. 125050 - 125050

Published: Dec. 5, 2024

Language: Английский

Citations

3
(Nano)biotechnological approaches in the treatment of cervical cancer: integration of engineering and biology DOI Creative Commons
Weimin Xie,

Zhengmei Xu

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 13, 2024

Cervical cancer is one of the most malignant gynaecological tumors characterised with aggressive behaviour tumor cells. In spite development different strategies for treatment cervical cancer, cells have developed resistance to conventional therapeutics. On other hand, nanoparticles been recently applied human cancers through delivery drugs and facilitate suppression. The stimuli-sensitive nanostructures can improve release therapeutics at site. present review, are discussed. Nanostructures deliver both chemotherapy natural compounds increase anti-cancer activity prevent drug in tumor. Moreover, genetic tools such as siRNA be delivered by enhance their accumulation order selectivity, stimuli-responsive pH- redox-responsive nanocarriers suppress induce photo-thermal photodynamic therapy accelerate cell death addition, nanobiotechnology demonstrates tremendous potential especially context immunotherapy. Overall, metal-, carbon-, lipid- polymer-based utilized therapy. Finally, hydrogels novel kinds carriers encapsulate activity.

Language: Английский

Citations

2
Exploring Nanohydrogels: Crafting Innovations for Biomedical Advancements DOI
Prakriti Sharma,

Tushank Ghosh,

Neha Sengupta

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(28)

Published: July 21, 2024

Abstract Here in, we discuss different types of nanohydrogels in the field biomedicine, highlighting their unique properties such as size, biocompatibility, and tuneable drug release capabilities. Nanohydrogels are considered versatile tools for applications tissue engineering, delivery, diagnostics, with ability to target specific sites therapeutic agents a controlled manner. The controlled‐release characteristics particularly emphasized targeted potentially transforming therapies conditions like cancer by maximizing treatment efficacy while minimizing damage healthy tissues. Several research articles published on has been steadily increasing over years, indicating growing interest activity this field. This review provides an overview contemporary methodologies employed nanohydrogel design, utilization biomedical contexts, pivotal role shaping advanced therapeutics. Recent investigations scrutinized extensive utility devising strategies conducive finely tuned biological applications. Challenges obstacles associated technology biomedicine also discussed. Cautious handling interaction complex systems is successful integration into medical

Language: Английский

Citations

1
The Application and Research Progress of Hydrogel Loading Stem Cells in Bone Regeneration DOI Creative Commons

Shenyu Zhao

MedScien, Journal Year: 2024, Volume and Issue: 1(7)

Published: June 6, 2024

Nowadays, osteogenesis technology is one of the hot topics in current orthopedic field. Globally, improving stability and efficiency bone regeneration has become a problem that society been studying. Due to its good tunability, compatibility, combination ability, hydrogel gradually applied technology. Stem cells can differentiate copy, have certain clinical potential treatment tissue. In recent years, many new types materials developed, some are expected be trials. Likewise, stem cell therapy also at forefront medical research today. Many characteristics make part them smoothly regeneration. this review, experimental data results cutting-edge developmental hydrogel-loading field collected, development application will summarized. The article contains nature, preparation, hydrogel; discusses effective role regeneration; combined with biological factor future technologies. focuses on different composite hydrogel. At same time, these hydrogels more efficient stable through characteristics. Therefore, review tells far-reaching impact technology, skeletal development, even organizational repair.

Language: Английский

Citations

0
In Vitro Preparation and Evaluation of Alendronate-Modified Hyaluronic Acid-Based Nanomicelles as a Bone-Targeted Drug Delivery Systems DOI

Mahrokh Sadat Alaei,

Fariba Ganji, Hossein Shaki

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
In Vitro Preparation and Evaluation of Alendronate-modified Hyaluronic acid-based Nanomicelles as a Bone-Targeted Drug Delivery System DOI

Mahrokh Sadat Alaei,

Fariba Ganji, Hossein Shaki

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106256 - 106256

Published: Oct. 5, 2024

Language: Английский

Citations

0
Development and In Vitro characterization of Azadirachta Indica Gum grafted polyacrylamide Based pH‐Sensitive Hydrogels to improve the Bioavailability of Lansoprazole DOI Open Access
Muhammad Abid Mustafa, Hafiz Rashid Hussain, Jawad Akbar Khan

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract The present study intended to develop a pH‐responsive hydrogel based on Neem gum (Ng) improve Lansoprazole (LSP) oral bioavailability. Azadirachta Indica seed extract was used obtain Ng. formulations (F1–F9) were prepared using different Ng ratios, Acrylamide (AAm), and methylene‐bis‐acrylamide (MBA). formulated hydrogels characterized through FTIR, thermal analysis, swelling ratio, SEM, sol‐gel In‐Vitro drug release, cytotoxicity analysis. extracted produce powder containing 21.5 % Prepared showed maximum at pH 7.4, whereas the an acidic insignificant. LSP‐loaded demonstrated regulated release of LSP for up 24 h indicated Super Case II transport mechanism. During cytotoxic evaluation, delivery system minimal towards normal cells, while percent carried out longer duration (up 96 h). revealed indica gum‐based as promising technique precisely delivering LSP.

Language: Английский

Citations

0