A Study of Antioxidant, Antihyperlipidemic, and Anti-Glycation Effects of Alkylsulfonic Acids with Quinobenzothiazinyl Substituents: In Vitro and In Silico Investigations DOI Creative Commons
Kirthani Anamalay,

Lay See Er,

Abbirami Balachandran

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 464 - 464

Published: April 12, 2025

Hyperlipidemia, marked by high levels of fats in the blood, is a major risk factor for non-communicable diseases such as type 2 diabetes, cardiovascular diseases, and cancer. It has been linked to action reactive oxygen species formation advanced glycation end products. Current treatments hyperlipidemia, like orlistat, simvastatin, atorvastatin, often present undesirable side effects, prompting need new therapeutic agents that are safer, more effective, cost-efficient, have fewer effects. In this context, compounds, specifically propano- butanosulfonic acids with 9-substituted quinobenzothiazinyl substituents, were synthesized through reactions quinobenzothiazines propane sultone or butane sultone. These novel quinobenzothiazine derivatives verified using 1H NMR, 13C HR-MS techniques. The research focused on assessing these compounds their toxicity, ability prevent glycation, antioxidant properties, potential combat hyperlipidemia. Toxicity was evaluated 3T3 L1 fibroblast cell line MTT assay. capacity tested bovine serum albumin–methylglyoxal albumin–glucose systems. This study measured total 2′,7′-dichlorodihydrofluorescein diacetate staining, assessed DPPH scavenging metal ion chelation tests. effectiveness against hyperlipidemia determined targeting cholesterol esterase pancreatic lipase activities, concentrations 5 12 ranging from 0.0245 0.268 μM. Standard drugs statins, aminoguanidine used positive controls various assays. Additionally, computational docking studies AutoDock Vina performed. resulting findings indicated non-toxic cells, effectively inhibited key enzymes related showed significant including prevention end-product formation. Compounds 11 demonstrated highest activity levels. promising results highlight lead development antihyperlipidemic drugs, although further necessary confirm efficacy safety.

Language: Английский

Base catalyzed one-pot thia-Michael addition-oxidation reaction of hetero-aromatic thiols to 2-aryl-3-nitro-2H-chromenes and their antibacterial evaluation DOI
Barsha Samanta, Bhabani Shankar Panda, Seetaram Mohapatra

et al.

New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(11), P. 4953 - 4959

Published: Jan. 1, 2024

A thia-Michael addition reaction was developed for the synthesis of heteroaromatic thiol-based 2 H -chromenes and antibacterial activity studied against two pathogenic bacterial strains, E. coli , S. aureus .

Language: Английский

Citations

6
A Study of Antioxidant, Antihyperlipidemic, and Anti-Glycation Effects of Alkylsulfonic Acids with Quinobenzothiazinyl Substituents: In Vitro and In Silico Investigations DOI Creative Commons
Kirthani Anamalay,

Lay See Er,

Abbirami Balachandran

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 464 - 464

Published: April 12, 2025

Hyperlipidemia, marked by high levels of fats in the blood, is a major risk factor for non-communicable diseases such as type 2 diabetes, cardiovascular diseases, and cancer. It has been linked to action reactive oxygen species formation advanced glycation end products. Current treatments hyperlipidemia, like orlistat, simvastatin, atorvastatin, often present undesirable side effects, prompting need new therapeutic agents that are safer, more effective, cost-efficient, have fewer effects. In this context, compounds, specifically propano- butanosulfonic acids with 9-substituted quinobenzothiazinyl substituents, were synthesized through reactions quinobenzothiazines propane sultone or butane sultone. These novel quinobenzothiazine derivatives verified using 1H NMR, 13C HR-MS techniques. The research focused on assessing these compounds their toxicity, ability prevent glycation, antioxidant properties, potential combat hyperlipidemia. Toxicity was evaluated 3T3 L1 fibroblast cell line MTT assay. capacity tested bovine serum albumin–methylglyoxal albumin–glucose systems. This study measured total 2′,7′-dichlorodihydrofluorescein diacetate staining, assessed DPPH scavenging metal ion chelation tests. effectiveness against hyperlipidemia determined targeting cholesterol esterase pancreatic lipase activities, concentrations 5 12 ranging from 0.0245 0.268 μM. Standard drugs statins, aminoguanidine used positive controls various assays. Additionally, computational docking studies AutoDock Vina performed. resulting findings indicated non-toxic cells, effectively inhibited key enzymes related showed significant including prevention end-product formation. Compounds 11 demonstrated highest activity levels. promising results highlight lead development antihyperlipidemic drugs, although further necessary confirm efficacy safety.

Language: Английский

Citations

0