Antigenotoxic Effects of Stachys viscosa (Lamiaceae), A Potential Medicinal Plant In Drosophila melanogaster DOI Open Access
Aygül Kılıç Karabulut, Mikail Açar

Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This research aimed to examine the anti-genotoxic properties of Stachys viscosa, a plant Lamiaceae family, which has medicinal and aromatic is widely used in cosmetics, food, pharmaceutical industries. The Drosophila wing somatic mutation recombination test (SMART), an vivo tool for evaluating recombination, was employed. effect S. viscosa against mitomycin C (MMC) mutagen investigated. study evaluated doses 5 mg, 15 45 60 mg concluding that effectively mitigated DNA damage induced by MMC. At 65 total number spots caused MMC suppressed 8.21% 13.17%, respectively. data collected indicate possesses certain properties.

Language: Английский

Small Steps to the Big Picture for Health‐Promoting Applications Through the Use of Chickweed (Stellaria media): In Vitro, In Silico, and Pharmacological Network Approaches DOI Creative Commons
Gaia Cusumano, Giancarlo Angeles Flores, Mehmet Veysi Çetiz

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(11), P. 9295 - 9313

Published: Oct. 3, 2024

ABSTRACT Stellaria media L., also called chickweed, is widespread in all parts of the world. In present study, we investigated biological properties and chemical profiles different extracts (ethyl acetate, ethanol, ethanol/water, water) S. . The were examined using UHPLC/MS/MS technique. Regarding properties, antioxidant as well enzyme‐inhibiting cytotoxic effects demonstrated by vitro methods. To obtain further information about structure‐ability relationship, network pharmacology molecular docking performed. Twelve phenolic compounds identified most them flavonoids (apigenin, kaempferol derivatives, etc.). water extract showed best free radical scavenging activity, while ethanol was active reducing power tests. When inhibiting AChE, ethyl acetate inhibitory effect. has a good effect on HepG2 (cell viability: 33.9% at concentration 100 g/mL). analysis, performed STRING database, included these 45 cancer‐associated targets. hub genes TP53, CDKN2A, PTEN, KRAS, HRAS. acacetin‐ O ‐hexoside‐ ‐deoxyhexoside napigenin‐7‐ ‐hexoside exhibit remarkable binding energies with proteins. Consequently, can be potential raw materials for designing functional formulations pharmaceutical, nutraceutical, cosmeceutical industries.

Language: Английский

Citations

12
Decoding chemical profiles and biological activities of aerial parts and roots of Eryngium thorifolium Boiss by HPLC-MS/MS, GC-MS and in vitro chemical assays DOI

Gokhan Zengin,

Sakina Yagi, Omayma A. Eldahshan

et al.

Food Bioscience, Journal Year: 2024, Volume and Issue: 61, P. 104556 - 104556

Published: June 12, 2024

Language: Английский

Citations

10
From small‐scale studies to an encompassing view: Inhibiting inflammation and clinically relevant enzymes with various extracts of Primula vulgaris using in vitro and in silico techniques DOI Creative Commons
İnci Kurt‐Celep,

Nilofar Nilofar,

Mehmet Veysi Çetiz

et al.

Food Frontiers, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 30, 2024

Abstract The genus Primula holds great importance as a source of traditional remedies in various folk medicine systems. In the present study, we investigated chemical composition and biological properties different extracts (ethyl acetate, ethanol, ethanol/water, water) aerial parts rhizomes vulgaris . To determine profile, were analyzed using ultrahigh performance liquid chromatography‐high‐resolution mass spectrometry (UHPLC‐HRMS) technique flavonoids major group this profile. antioxidant capacity was demonstrated by vitro tests general ethanol/water extract found to be most potent. Enzyme inhibition studied against enzymes ethanol more active than others. assess anti‐inflammatory potential at molecular level, human dermal fibroblasts (HDF) treated with lipopolysaccharide (LPS). experiments showed that levels nuclear factor kappa B (NFKB), receptor for advanced glycation endproducts (RAGE), activator protein‐1 (AP‐1), interleukin 6 (IL‐6), 17 (IL‐17) tumor necrosis (TNF)‐alpha significantly reduced after treatment tested extracts. addition, an inhibitory effect on collagenase, elastase, hyaluronidase, which are involved inflammatory process destabilization extracellular matrix (ECM). P. has been observed modulate metalloproteinase (MMP) synthesis decreasing concentration cellular reactive oxygen species (ROS) during LPS‐induced inflammation. This study also examined binding dynamic behavior proteins associated skin infections ligands derived from Simulations AutoDock Vina V1.1.2 GROMACS 2023.1 isoquercetin particular superior interactions hyaluronidase. These findings important development therapeutic strategies health infection control. summary, can considered natural bioactive compounds effective health‐promoting applications nutraceuticals, pharmaceuticals, cosmetics

Language: Английский

Citations

5
A rich source of natural compounds: comprehensive research on biological properties of Lamium orientale DOI
Enis Fuat Tüfekci, Ebrar Çağlıyan, Gamze Burcu Balcı

et al.

Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 14

Published: Feb. 26, 2025

Language: Английский

Citations

0
PRODUCTION AND CHARACTERIZATION OF BACTERIAL CELLULOSE BIOCOMPOSITES BASED ON THYMUS SIPYLEUS BOISS. EXTRACT DOI Open Access
Nur KILINÇ, Dicle ÖZDEMİR KÜÇÜKÇAPRAZ, Mustafa Cüce

et al.

Mühendislik Bilimleri ve Tasarım Dergisi, Journal Year: 2025, Volume and Issue: 13(1), P. 165 - 176

Published: March 19, 2025

The aim of this study was to improve the antibacterial properties bacterial cellulose (BC) produced by ex situ modification in Kombucha culture medium. Bioactive methanol extract from plant Thymus sipyleus Boiss. added BC obtain a bioactive and cost-effective biocomposite. SEM FTIR analyses confirmed nanofibers, porous structure chemical bonding with nanofibers revealed that biocomposites were successfully produced. A significant decrease water retention swelling behavior observed biocomposites. activity determined according AATC100-2004 method. bactericidal activities compared those gram-positive bacteria Staphylococcus aureus ATCC 25923 gram-negative Escherichia coli 25922. Biocomposite T010 (0.10% extract) showed strong activity, reducing E. 84.6% S. 97.54%. results show T. can be used as an effective agent at appropriate concentrations biocomposite has excellent properties.

Language: Английский

Citations

0
Characterising the Metabolomic Diversity and Biological Potentials of Extracts from Different Parts of Two Cistus Species Using UHPLC-MS/MS and In Vitro Techniques DOI Creative Commons

Shakeel Ahmed,

Gökhan Zengin, Selami Selvı

et al.

Pathogens, Journal Year: 2024, Volume and Issue: 13(9), P. 795 - 795

Published: Sept. 13, 2024

This study investigates the biochemical composition and biological properties of different parts (leaves, roots, twigs) two

Language: Английский

Citations

1
Chemical Constituents, Antioxidant, and Enzyme Inhibitory Potentials Supported by In‐Silico Studies of the n‐Hexane Extract and Essential Oil of Platycladus orientalis (L.) Franco Leaves DOI Open Access
Doaa A. Korany,

Nilofar Nilofar,

Gökhan Zengin

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 28, 2024

Abstract Platycladus orientalis leaves are widely used in traditional medicine to treat different ailments. In the present study, volatile constituents were obtained by n ‐hexane extraction and hydrodistillation. Comprehensive metabolomic profiling was performed using GC‐MS analysis. Furthermore, vitro antioxidant potential enzyme‐inhibitory activity assessed supported silico profiling. Results revealed predominance of monoterpene hydrocarbons hydrodistilled oil (42.30 %) followed oxygenated sesquiterpenes (32.10 %); with cedrol as main component. Diterpenoids (49.70 sesquiterpene (13.43 major components extract; vulgarol A, a diterpene alcohol, constituent. The demonstrated significantly higher across all assays, including ABTS DDPH scavenging activity, CUPRAC, FRAP assays. However, extract broad inhibitory effects against butyrylcholinesterase, tyrosinase, α ‐amylase, ‐glucosidase enzymes, molecular docking study predictive ADME Therefore, it may be concluded that is viable option for treating dysregulated enzyme conditions. addition, use pharmaceutical industries management oxidative stress can inferred. These results warrant further studies validate therapeutic extract.

Language: Английский

Citations

1
Investigating the phytochemical profile, biological potentials, morphological, and anatomical characteristics of Cyclotrichium origanifolium (Labill.) Manden. & Scheng. (Lamiaceae) from Turkey DOI
Bilge Aydın, Satuk Buğra Alkuyruk, Enes Tekman

et al.

PROTOPLASMA, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 2, 2024

Language: Английский

Citations

0
Antigenotoxic Effects of Stachys viscosa (Lamiaceae), A Potential Medicinal Plant In Drosophila melanogaster DOI Open Access
Aygül Kılıç Karabulut, Mikail Açar

Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 23, 2024

This research aimed to examine the anti-genotoxic properties of Stachys viscosa, a plant Lamiaceae family, which has medicinal and aromatic is widely used in cosmetics, food, pharmaceutical industries. The Drosophila wing somatic mutation recombination test (SMART), an vivo tool for evaluating recombination, was employed. effect S. viscosa against mitomycin C (MMC) mutagen investigated. study evaluated doses 5 mg, 15 45 60 mg concluding that effectively mitigated DNA damage induced by MMC. At 65 total number spots caused MMC suppressed 8.21% 13.17%, respectively. data collected indicate possesses certain properties.

Language: Английский

Citations

0