Synthetic Communications,
Journal Year:
2024,
Volume and Issue:
54(22), P. 1984 - 2002
Published: Oct. 24, 2024
Ultrasonic
waves
were
used
for
synthesis
of
novel
hydrazones,
bishydrazones,
pyrazoles,
1,2,4-triazole
and
1,3,4-oxadiazole.
The
structural
formulae
the
synthesized
compounds
elucidated
in
terms
elemental
spectroscopic
analyses.
All
estimated
by
testing
total
antioxidant
capacity,
iron‐reducing
power,
scavenging
activity
against
ABTS
DPPH
radicals
addition
to
anti‐diabetic,
anti‐Alzheimer
anti‐arthritic
activities.
displayed
good
potent
bioactivity.
Compounds
6,
10
exhibit
highest
free
Furthermore,
demonstrate
strongest
inhibition
α‐amylase
α-glucosidase.
Compound
12
acetylcholinesterase
among
prepared
compounds.
However,
18a,b,
19
show
a
significantly
higher
percentage
protein
denaturation
proteinase.
most
bioactive
investigated
toward
docking
methodology
appropriate
protein.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(18), P. 3828 - 3833
Published: April 29, 2024
The
photocatalyzed
radical-triggered
thio/selenosulfonylation–bicyclization
of
indole-tethered
1,6-enynes
has
been
established
for
the
first
time,
enabling
synthesis
various
previously
unreported
thio/selenosulfonylated
benzo[c]pyrrolo[1,2,3-lm]carbazoles
with
moderate
to
good
yields
under
mild
conditions.
reaction
pathway
was
proposed,
consisting
energy
transfer,
homolytic
cleavage,
radical
addition,
5-exo-dig,
coupling,
and
a
Mallory
cascade.
This
approach
exhibits
wide
substrate
compatibility
excellent
tolerability
toward
functional
groups
is
characterized
by
its
remarkable
efficiency
in
both
bond
formation
annulation.
Oriental Journal Of Chemistry,
Journal Year:
2025,
Volume and Issue:
41(1), P. 30 - 43
Published: Feb. 28, 2025
Thiazolidinones
are
multifaceted
compounds
with
considerable
pharmacological
potential
owing
to
their
chemical
structure,
which
permits
alterations
such
as
ring
substitution
and
functionalization.
They
demonstrate
diverse
actions,
encompassing
antibacterial,
anticancer,
anti-inflammatory,
antidiabetic,
neuroprotective
properties.
engage
targets
PPAR-γ,
NF-κB,
COX
enzymes,
DNA
topoisomerases.
Thiazolidinediones
recognized
for
insulin-sensitizing
effects,
functioning
PPAR-γ
agonists
in
the
management
of
type
2
diabetes.
Improvements
formulation
strategies
increase
its
bioavailability
effectiveness.
Future
research
should
concentrate
on
individualized
therapy,
sophisticated
delivery
systems,
synergistic
combinations
additional
medicinal
medicines.
