Recent progress in synthetic strategies for novel β-lactams linked with five-membered heterocycles (N/O/S): advances in medicinal chemistry (2020–2025)
Ankita Garg,
No information about this author
Dolar Dureja,
No information about this author
Raaina Pasricha
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et al.
Medicinal Chemistry Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 12, 2025
Language: Английский
Exploring the Recent Pioneering Developments of Small Molecules in Antimalarial Drug Armamentarium: A Chemistry Prospective Appraisal
Tameika Bagratee,
No information about this author
Ritika Prawlall,
No information about this author
Thabani Ndlovu
No information about this author
et al.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(8)
Published: May 17, 2024
Malaria
is
a
very
destructive
and
lethal
parasitic
disease
that
causes
significant
mortality
worldwide,
resulting
in
the
loss
of
millions
lives
annually.
It
an
infectious
transmitted
by
mosquitoes,
which
caused
different
species
parasite
protozoan
belonging
to
genus
Plasmodium.
The
uncontrolled
intake
antimalarial
drugs
often
employed
clinical
settings
has
resulted
emergence
numerous
strains
plasmodium
are
resistant
these
drugs,
including
multidrug-resistant
strains.
This
resistance
significantly
diminishes
effectiveness
many
primary
used
treatment
malaria.
Hence,
there
urgent
need
for
developing
unique
classes
function
with
distinct
mechanisms
action.
In
this
context,
design
development
hybrid
compounds
combine
pharmacophoric
properties
from
lead
molecules
into
single
unit
gives
perspective
towards
further
malaria
next
generation.
recent
years,
field
medicinal
chemistry
made
efforts
discovery
synthesis
small
novel
exhibit
potent
properties,
while
also
demonstrating
reduced
toxicity
desirable
efficacy.
light
this,
we
have
reviewed
progress
agents
2021
up
present.
manuscript
presents
comprehensive
overview
latest
advancements
pertaining
molecules,
specific
focus
on
their
potential
as
agents.
As
possible
might
target
both
dual
stage
multi-stage
stages
life
cycle,
been
studied.
review
explores
variety
physiologically
active
described
literature
order
lay
strong
foundation
logical
eventual
identification
based
frameworks.
Language: Английский
Synthesis, Characterization, Antimicrobial and In Silico Studies of isatin Schiff base linked 1,2,3‐triazole hybrids
Vijay Kumar,
No information about this author
Akanksha Bhukal,
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Anirudh Pratap Singh Raman
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et al.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(7)
Published: May 21, 2024
A
new
series
of
isatin-Schiff
base
linked
1,2,3-triazole
hybrids
has
been
synthesized
using
CuAAC
approach
from
(E)-3-(phenylimino)-1-(prop-2-yn-1-yl)indolin-2-one
derivatives
in
high
yield
(73-91
%).
These
were
characterized
FT-IR,
Language: Английский
An insights into structural diversity of β-lactam scaffold towards varied medicinal applications: A comprehensive update (2020–2024)
Ankita Garg,
No information about this author
Teesha Thakral,
No information about this author
Radhakrishan Dhiman
No information about this author
et al.
Tetrahedron Letters,
Journal Year:
2024,
Volume and Issue:
153, P. 155383 - 155383
Published: Nov. 16, 2024
Language: Английский
Coumarin‐modified ruthenium complexes: Synthesis, characterization, and antiproliferative activity against human cancer cells
Archiv der Pharmazie,
Journal Year:
2024,
Volume and Issue:
357(9)
Published: June 12, 2024
Among
ruthenium
complexes
studied
as
anticancer
metallodrugs,
NKP-1339,
NAMI-A,
RM175,
and
RAPTA-C
have
already
entered
clinical
trials
due
to
their
potent
antitumor
activity
demonstrated
in
preclinical
studies
reduced
toxicity
comparison
with
platinum
drugs.
Considering
the
advantages
of
ruthenium-based
drugs
cytostatic
organometallic
triazole-
coumarin-derived
ligands,
we
set
out
synthesize
Ru(II)
coumarin-1,2,3,-triazole
hybrids
(L)
general
formula
[Ru(L)(p-cymene)(Cl)]ClO
Language: Английский