Therapeutic Efficacy of Quercetin and Its Nanoformulation Both the Mono‐ or Combination Therapies in the Management of Cancer: An Update with Molecular Mechanisms

Journal of Tropical Medicine, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Quercetin, a major representative of the flavonol subclass found abundantly in almost all edible vegetables and fruits, showed remarkable therapeutic properties was beneficial numerous degenerative diseases by preventing lipid peroxidation. Quercetin is different diseases, such as atherosclerosis chronic inflammation. This study aims to find out anticancer activities quercetin determine mechanisms pathways which are responsible for effect. It also revealed biopharmaceutical, toxicological characteristics, clinical utilization evaluate its suitability further investigations reliable drug. All relevant data concerning this compound with cancer collected using scientific search engines, including PubMed, Springer Link, Wiley Online, Web Science, SciFinder, ScienceDirect, Google Scholar. review demonstrated that strong properties, apoptosis, inhibition cell proliferation, autophagy, cycle arrest, angiogenesis, invasion migration against various types cancer. Findings could significantly moderate regulate pathways, PI3K/AKT‐mTORC1 pathway, JAK/STAT signaling system, MAPK MMP NF‐ κ B p‐Camk2/p‐DRP1 pathway. However, poor oral bioavailability due reduced absorption; limitation overcome applying nanotechnology (nanoformulation quercetin). Moreover, expressed no toxic effect investigated subjects. Based on view these findings, it might be considered chemotherapeutic drug candidate treatment cancers. more studies suggested establish proper efficacy, safety, human dose.

Language: Английский

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trans‐Ferulic Acid Antagonizes the Anti‐Inflammatory Activity of Etoricoxib: Possible Interaction of COX‐1 and NOS

Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

ABSTRACT This study emphasizes to investigate the modulatory activity of trans ‐ferulic acid (TFA) on anti‐inflammatory etoricoxib (ETO) and underlying mechanisms via formalin‐induced licking paw edema model in silico study. Inflammation was induced by injecting formalin (50 µL) into right hind mice. The animals were treated with different doses TFA (25, 50, 75 mg/kg, p.o.). vehicle ETO (35 p.o.) provided as positive negative control, respectively. also served combined evaluate activity. behavior counted for early late phases, whereas diameter measured using a slide caliper. All treatment continued 7 days until totally minimized determine inflammation's recovery capability specific group. Different computed web tools used estimate molecular binding affinity, interactions, pharmacokinetics. findings demonstrated that significantly (p < 0.05) enhanced onset reduced number licks compared showed significant diminished complete recovered after 5 indicating effects. However, notably effects enhancing number. expressed elevated affinity −7.5 −6.5 kcal/mol toward nitric oxide (NO) synthase COX‐1, In conclusion, exerted reduces ETO.

Language: Английский

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Assessment of Antihyperglycemic and Modulatory Effects of trans‐Ferulic Acid on Glibenclamide and Metformin: In Vivo and Molecular Docking Studies

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(14)

Published: April 1, 2025

Abstract Diabetes mellitus (DM) is a chronic metabolic disorder characterized by persistent hyperglycemia due to impaired insulin secretion, resistance, or both. trans ‐Ferulic acid (TFA) has several biological activities, including sedative, anxiolytic, anti‐inflammatory, and so on. However, there no in vivo silico study on the antihyperglycemic activity of TFA. This assessed antidiabetic potential TFA its modulatory effect glibenclamide (GLI) metformin (MET) through hypoglycemic tests mice molecular docking targeting glucose metabolism proteins. (25, 50, 75 mg/kg, p.o.) was tested glucose‐induced hyperglycemic alongside GLI (10 MET (100 p.o.), with blood levels (BGLs) monitored. significantly ( p < 0.05) reduced BGLs dose‐dependent manner, mg/kg dose achieving 30.99% reduction at 180 min, compared 52.04% 55.27% (MET). Combination therapy (TFA‐50+GLI‐10 TFA‐50+MET‐100) further enhanced glucose‐lowering effects, TFA‐50+GLI‐10 showing highest (58.90%). In analysis revealed that exhibited elevated binding affinities complex I (−6.4 kcal/mol) mitochondrial glycerol‐3‐phosphate dehydrogenase (−6.8 kcal/mol). These findings suggest significant potential, supporting role regulation.

Language: Английский

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Trans-Ferulic acid reduces the sedative activity of diazepam in thiopental sodium-induced sleeping mice: A potential GABAergic transmission

Neurotoxicology and Teratology, Journal Year: 2024, Volume and Issue: 106, P. 107403 - 107403

Published: Nov. 1, 2024

Language: Английский

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