Recent advancements in the multifaceted biomedical efficacy of triazole based metal complexes
Aman Kumar,
No information about this author
Seema Devi,
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Sanjeev Kumar
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et al.
Coordination Chemistry Reviews,
Journal Year:
2025,
Volume and Issue:
536, P. 216675 - 216675
Published: April 10, 2025
Language: Английский
Novel triazole-tethered thiazol-4(5H)-one hybrids as potential therapeutics for obesity and type 2 diabetes: in vitro, in vivo, and in silico evaluations
Journal of Molecular Structure,
Journal Year:
2025,
Volume and Issue:
unknown, P. 142577 - 142577
Published: May 1, 2025
Language: Английский
A Click Chemistry Approach for the Synthesis of Triazole Linked Vanillin Scaffolds as Potent Pharmacophores: Anti-Diabetic, Anti-Inflammatory, Antioxidant, Molecular Docking and ADMET Investigations
Polycyclic aromatic compounds,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 24
Published: May 26, 2025
Language: Английский
Novel and efficient synthesis of 5-chloro-6-methoxy-3-(2-((1-(aryl)-1H-1,2,3-triazol-4-yl)methoxy)ethyl)benzo[d]isoxazole derivatives as new α-glucosidase inhibitors
Ram Reddy Mudireddy,
No information about this author
Rambabu Gundla,
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Chandra Prakash Koraboina
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et al.
Biochemistry and Biophysics Reports,
Journal Year:
2025,
Volume and Issue:
43, P. 102074 - 102074
Published: June 5, 2025
Language: Английский
Importance of the CuAAC Reaction in the Synthesis of Platinum Complexes with 1,4-Disubstituted-1H-1,2,3-triazoles: A Review of Their Anticancer Activity
Reactions,
Journal Year:
2024,
Volume and Issue:
5(4), P. 947 - 983
Published: Nov. 24, 2024
Despite
multiple
advances
in
treatment
and
prevention,
cancer
remains
one
of
the
leading
causes
death
worldwide.
Chemotherapy
most
effective
method
for
treatment.
However,
commercial
chemotherapeutic
drugs
have
limited
efficacy,
severe
side
effects,
acquired
resistance.
Therefore,
scientific
community
has
devoted
a
great
effort
to
designing
new,
more
effective,
cheaper
drugs.
In
this
sense,
copper-catalyzed
azide-alkyne
cycloaddition
reactions
(CuAAC)
provide
1,4-disubstituted
1H-1,2,3-triazoles
high
yields
without
forming
by-products.
This
reaction
allows
easy,
efficient,
functional,
ordered,
rapid,
selective,
specific
joining
small
molecules,
giving
rise
complex
molecules.
The
CuACC
simplifies
synthesis
processes,
accelerating
discovery
new
agents
by
allowing
platinum
drugs,
slightly
altering
their
structure,
or
creating
molecules
with
improved
properties.
work
shows
importance
CuAAC
search
metallodrugs
possible
anticancer
activity.
Language: Английский
Cardiometabolic Index is associated with heart failure: a cross-sectional study based on NHANES
Frontiers in Medicine,
Journal Year:
2024,
Volume and Issue:
11
Published: Dec. 9, 2024
Heart
failure
is
a
complex
syndrome
characterized
by
impaired
cardiac
function.
Despite
improvements
in
treatment,
the
prevalence
of
heart
continues
to
rise.
The
Cardiometabolic
Index
(CMI),
novel
measure
combining
abdominal
obesity
and
lipid
levels,
has
emerged
as
potential
predictor
metabolic
risk.
Language: Английский