Therapeutic Potential of Artemisia campestris Essential Oil: Antioxidant, Anti‐Inflammatory, and Anticancer Insights From In Silico Analysis DOI Open Access

Inasse Cherfi,

Mahboub Nasma, Gamil Gamal Hasan

et al.

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 7, 2025

Artemisia campestris subsp. (tuguft) is a medicinal plant traditionally used in Algerian medicine. This study investigates the chemical composition and bioactivity of its essential oil (ACEO). Gas chromatography-mass spectrometry (GC-MS) analysis identified key compounds, including linalyl acetate (2.92%), geranyl (2.45%), eucalyptol (1.38%). ACEO demonstrated significant antioxidant activity, with IC50 values 11.09 μg/mL (DPPH), 15.81 (FRAP), 22.70 (β-carotene). It also enhanced peroxidase activity by 82.67 U/g. The anti-inflammatory effects were confirmed an 18.87 μg/mL. Notably, silico molecular docking revealed that 3-cyclopentyl-N-(2-(3,4-dimethoxyphenyl)ethyl) exhibits strong binding affinity to phosphoinositide 3-kinase gamma, target for pancreatic cancer therapy, suggesting potential anticancer activity. These findings underscore therapeutic ACEO, highlighting antioxidant, anti-inflammatory, properties.

Language: Английский

Therapeutic Potential of Artemisia campestris Essential Oil: Antioxidant, Anti‐Inflammatory, and Anticancer Insights From In Silico Analysis DOI Open Access

Inasse Cherfi,

Mahboub Nasma, Gamil Gamal Hasan

et al.

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 7, 2025

Artemisia campestris subsp. (tuguft) is a medicinal plant traditionally used in Algerian medicine. This study investigates the chemical composition and bioactivity of its essential oil (ACEO). Gas chromatography-mass spectrometry (GC-MS) analysis identified key compounds, including linalyl acetate (2.92%), geranyl (2.45%), eucalyptol (1.38%). ACEO demonstrated significant antioxidant activity, with IC50 values 11.09 μg/mL (DPPH), 15.81 (FRAP), 22.70 (β-carotene). It also enhanced peroxidase activity by 82.67 U/g. The anti-inflammatory effects were confirmed an 18.87 μg/mL. Notably, silico molecular docking revealed that 3-cyclopentyl-N-(2-(3,4-dimethoxyphenyl)ethyl) exhibits strong binding affinity to phosphoinositide 3-kinase gamma, target for pancreatic cancer therapy, suggesting potential anticancer activity. These findings underscore therapeutic ACEO, highlighting antioxidant, anti-inflammatory, properties.

Language: Английский

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