STAT3 Signaling Pathway in Health and Disease

MedComm, Journal Year: 2025, Volume and Issue: 6(4)

Published: March 30, 2025

ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical factor involved in multiple physiological pathological processes. While STAT3 plays an essential role homeostasis, its persistent activation has been implicated the pathogenesis various diseases, particularly cancer, bone‐related autoimmune disorders, inflammatory cardiovascular neurodegenerative conditions. The interleukin‐6/Janus kinase (JAK)/STAT3 signaling axis central to activation, influencing tumor microenvironment remodeling, angiogenesis, immune evasion, therapy resistance. Despite extensive research, precise mechanisms underlying dysregulated disease progression remain incompletely understood, no United States Food Drug Administration (USFDA)‐approved direct inhibitors currently exist. This review provides comprehensive evaluation STAT3's health disease, emphasizing involvement cancer stem cell maintenance, metastasis, inflammation, drug We systematically discuss therapeutic strategies, including JAK (tofacitinib, ruxolitinib), Src Homology 2 domain (S3I‐201, STATTIC), antisense oligonucleotides (AZD9150), nanomedicine‐based delivery systems, which enhance specificity bioavailability while reducing toxicity. By integrating molecular mechanisms, pathology, emerging interventions, this fills knowledge gap STAT3‐targeted therapy. Our insights into crosstalk, epigenetic regulation, resistance offer foundation for developing next‐generation with greater clinical efficacy translational potential.

Language: Английский

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Copper in Gynecological Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17578 - 17578

Published: Dec. 17, 2023

Copper (Cu) is an essential micronutrient for the correct development of eukaryotic organisms. This metal plays a key role in many cellular and physiological activities, including enzymatic activity, oxygen transport, cell signaling. Although redox activity Cu crucial reactions, this property also makes it potentially toxic when found at high levels. Due to dual action Cu, highly regulated mechanisms are necessary prevent both deficiency accumulation since its dyshomeostasis may favor multiple diseases, such as Menkes' Wilson's neurodegenerative diabetes mellitus, cancer. As relationship between cancer has been most studied, we analyze how can affect three fundamental processes tumor progression: proliferation, angiogenesis, metastasis. Gynecological diseases characterized by prevalence, morbidity, mortality, depending on case, mainly include benign malignant tumors. The that promote their progression affected occur be similar. We crosstalk deregulation gynecological focusing therapeutic strategies derived from metal.

Language: Английский

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Biofabrication of ecofriendly copper oxide nanoparticles and their applications in breast cancer therapy

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 160, P. 111917 - 111917

Published: Dec. 15, 2023

Language: Английский

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Olive leaf extract green-formulated manganese nanoparticles: Characterization and antioxidant, cytotoxicity and anti-breast carcinoma properties

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 163, P. 112376 - 112376

Published: March 31, 2024

Language: Английский

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Investigating the Anticancer Potential of Biochanin A in KB Oral Cancer Cells Through the NFκB Pathway

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(7)

Published: Oct. 1, 2024

ABSTRACT Squamous cell carcinoma (SCC) is a malignancy primarily affecting squamous cells. Its development linked to multiple risk factors, such as alcohol and tobacco consumption, human papillomavirus (HPV) infection, Epstein‐Barr Virus (EBV) infection. Biochanin A (BCA), phytoestrogen extracted from red clover, has been extensively researched for its therapeutic properties. It spans antioxidant activity, anti‐inflammatory effects, neuroprotection, cardioprotection, anticancer potential in different bodily systems. However, impact on oral cancer remains unexplored. Therefore, this investigation aims assess the effects of BCA, specifically KB This study utilized cells evaluate BCA various cellular parameters, including viability, apoptosis, intracellular ROS production, mitochondrial membrane potential, migration. treatment induced several notable cells, reduced altered morphology suggestive heightened oxidative stress, alterations potential. Moreover, demonstrated an inhibitory effect The further investigated enzyme activities lipid peroxidation, revealing decreased increased peroxidation across concentrations (IC 50 IC 90 ). Immunocytochemistry qRT‐PCR analyses unveiled that at varying doses ) downregulated expression nuclear factor‐κB (NF‐κB) subunits p50 p65, pivotal players progression. In summary, sheds light promising agent treating cancer. ability induce perturb functions, modulate gene within underscores significance. Nonetheless, research, particularly following animal studies, imperative comprehensively grasp breadth BCA's viability clinical applications.

Language: Английский

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Au@hydroxyapatite nanocomposite as a novel apoptosis Inducer and NF-κB translocation Inhibitor in prostate cancer cell line

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 170, P. 113469 - 113469

Published: Nov. 8, 2024

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Review to Elucidate the Correlation between Cuproptosis-Related Genes and Immune Infiltration for Enhancing the Detection and Treatment of Cervical Cancer

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10604 - 10604

Published: Oct. 1, 2024

Copper is a vital trace element in oxidized and reduced forms. It plays crucial roles numerous biological events such as redox chemistry, enzymatic reactions, mitochondrial respiration, iron metabolism, autophagy, immune modulation. Maintaining the balance of copper body essential because its deficiency excess can be harmful. Abnormal metabolism has two-fold impact on development tumors cancer treatment. Cuproptosis form cell death that occurs when there excessive body, leading to proteotoxic stress activation specific pathway mitochondria. Research been conducted advantageous role ionophores chelators management. This review presents recent progress understanding cuproptosis, molecular mechanisms involved using for targeted therapy cervical cancer. Integrating metals minerals into nanoparticulate systems promising approach controlling invasive tumors. Therefore, we have also included concise overview nanoformulations targeting cells. offers comprehensive insights correlation between cuproptosis-related genes infiltration, well prognosis These findings valuable developing advanced clinical tools enhance detection treatment

Language: Английский

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Anticancer potential of Cu4O3 NPs against human ovarian teratocarcinoma: an in-vitro validation

Chemical Papers, Journal Year: 2023, Volume and Issue: 78(5), P. 2811 - 2821

Published: Dec. 29, 2023

Language: Английский

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