Comprehension of PTEN-Regulated MicroRNA Profiling in Oral Premalignant Lesions: A Critical Link to Early Detection of Oral Squamous Cell Carcinoma

Cureus, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Oral premalignant lesions represent the most prevalent observed within oral cavity. These generally remain asymptomatic until they advance to more severe stages, at which point their progression squamous cell carcinoma (OSCC) becomes evident. Addressing this transformation necessitates further investigative efforts. The PTEN (phosphatase and tensin homolog) gene functions as a crucial tumor suppressor, with its expression regulated by variety of complex mechanisms, including transcriptional, post-transcriptional, post-translational processes. MicroRNAs (miRNAs) are significant modulators play an integral role in transition from OSCC. This review evaluates impact miRNA dysregulation on examines continuum model suppression. It posits that loss functionality may transpire without alterations DNA sequence, particularly through mechanisms associated regulation. Furthermore, discourse elucidates structural interactions between miRNAs, context lesions, influence rate Such insights for informing treatment strategies. also explores potential targeting specific miRNAs restore functionality, intending improve clinical outcomes patients diagnosed By elucidating these regulatory interactions, analysis aims identify pathways conducive development targeted therapeutic

Language: Английский

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SEMA6B promotes thyroid tumorigenesis and chemoresistance via WNT/β-catenin signaling in response to doxorubicin

American Journal of Cancer Research, Journal Year: 2025, Volume and Issue: 15(4), P. 1540 - 1558

Published: Jan. 1, 2025

Thyroid cancer (THCA) is the most common endocrine malignancy and typically has a favorable prognosis. However, aggressive subtypes, particularly anaplastic thyroid carcinoma, present significant treatment challenges due to their high metastatic potential resistance conventional therapies. Therefore, better understanding of underlying mechanisms essential for improving strategies. Herein, we aimed investigate role SEMA6B in THCA progression explore its associated molecular mechanisms. Differentially expressed genes (DEGs) was screened using RNA sequencing data from paired normal tissues 10 patients. The expression functional were further examined datasets TCGA GEO. Functional assays conducted evaluate effects overexpression knockout on cell proliferation. In vivo xenograft performed validate these findings. Additionally, impact WNT/β-catenin signaling pathway verified. highly significantly with poor clinical outcomes. increased proliferation colony formation, whereas reduced enhanced sensitivity Doxorubicin. Mechanistically, found promote activation pathway. conclusion, reveal novel oncogenic SEMA6B/WNT/β-catenin THCA, providing new insights avenues therapeutic intervention.

Language: Английский

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Expression profiles of serum transfer RNA-derived fragments and their potential roles in non-small cell lung cancer

Translational Cancer Research, Journal Year: 2024, Volume and Issue: 13(7), P. 3668 - 3677

Published: July 1, 2024

Non-small cell lung cancer (NSCLC) is one of the malignant tumors with highest morbidity and mortality in world. Early diagnosis can significantly improve prognosis patients. Transfer RNA (tRNA)-derived fragments (tRFs) have been found to a crucial function pathophysiology cancers. However, role tRFs/tRNA halves (tiRNAs) NSCLC yet unknown. The present study aimed investigate unique expression profiles tRFs/tiRNAs search novel biomarkers for diagnosis.

Language: Английский

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