Physiological markers for immunotherapeutics: a review DOI

Durlav Chowdhury,

Ashmita Das,

Mrityunjay Mishra

et al.

Journal of Chemotherapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: Dec. 22, 2024

Immunotherapy has been advanced through multiple approaches, including immunogenic cytokines, monoclonal antibodies, therapeutic vaccinations, adoptive cell transfer, stem transplantation, and oncolytic viruses. This review analyses various strategies in genomics, transcriptomics, single-cell techniques, computational analysis, big data, imaging technologies for the identification of tumour microbiota microenvironments. is becoming acknowledged as a feasible cancer treatment method, facilitating innovative medicines personalized medicine techniques.

Language: Английский

Microbes in the tumor microenvironment: New Additions to break the Tumor Immunotherapy Dilemma DOI
Lujia Zhou,

Shiying Fan,

Wenjie Zhang

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: 285, P. 127777 - 127777

Published: May 24, 2024

Language: Английский

Citations

5
Tumor microbiome: roles in tumor initiation, progression, and therapy DOI Creative Commons

Shengxin Zhang,

Jing Huang,

Z. X. Jiang

et al.

Molecular Biomedicine, Journal Year: 2025, Volume and Issue: 6(1)

Published: Feb. 8, 2025

Abstract Over the past few years, tumor microbiome is increasingly recognized for its multifaceted involvement in cancer initiation, progression, and metastasis. With application of 16S ribosomal ribonucleic acid (16S rRNA) sequencing, intratumoral microbiome, also referred to as tumor-intrinsic or tumor-resident has been found play a significant role microenvironment (TME). Understanding their complex functions critical identifying new therapeutic avenues improving treatment outcomes. This review first summarizes origins composition these microbial communities, emphasizing adapted diversity across diverse range types stages. Moreover, we outline general mechanisms by which specific microbes induce including activation carcinogenic pathways, deoxyribonucleic (DNA) damage, epigenetic modifications, chronic inflammation. We further propose may evade immunity promote angiogenesis support while uncovering influences on each step metastatic cascade, such invasion, circulation, seeding secondary sites. Additionally, closely associated with drug resistance efficacy modulating immune responses, metabolism, apoptotic pathways. Furthermore, explore innovative microbe-based strategies, engineered bacteria, oncolytic virotherapy, other modalities aimed at enhancing immunotherapeutic efficacy, paving way microbiome-centered frameworks.

Language: Английский

Citations

0
Physiological markers for immunotherapeutics: a review DOI

Durlav Chowdhury,

Ashmita Das,

Mrityunjay Mishra

et al.

Journal of Chemotherapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24

Published: Dec. 22, 2024

Immunotherapy has been advanced through multiple approaches, including immunogenic cytokines, monoclonal antibodies, therapeutic vaccinations, adoptive cell transfer, stem transplantation, and oncolytic viruses. This review analyses various strategies in genomics, transcriptomics, single-cell techniques, computational analysis, big data, imaging technologies for the identification of tumour microbiota microenvironments. is becoming acknowledged as a feasible cancer treatment method, facilitating innovative medicines personalized medicine techniques.

Language: Английский

Citations

0